7BQ3

X-ray structure of human PPARalpha ligand binding domain-GW7647-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 2VN A 501

Chain	Residue
A	PHE273
A	HOH613
A	HOH617
A	CYS276
A	GLN277
A	THR279
A	SER280
A	TYR314
A	MET355
A	HIS440
A	TYR464

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1

Chain	Residue	Details
A	SER280
A	TYR314
A	TYR464

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Essential for heterodimerization with RXRA

Chain	Residue	Details
A	LEU433

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