Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7BP3

Cryo-EM structure of the human MCT2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005477	molecular_function	pyruvate secondary active transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008028	molecular_function	monocarboxylic acid transmembrane transporter activity
A	0015129	molecular_function	lactate transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015355	molecular_function	secondary active monocarboxylate transmembrane transporter activity
A	0015718	biological_process	monocarboxylic acid transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0035873	biological_process	lactate transmembrane transport
A	0035879	biological_process	plasma membrane lactate transport
A	0042802	molecular_function	identical protein binding
A	0050833	molecular_function	pyruvate transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0098685	cellular_component	Schaffer collateral - CA1 synapse
A	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
A	0098688	cellular_component	parallel fiber to Purkinje cell synapse
A	0098839	cellular_component	postsynaptic density membrane
A	0098978	cellular_component	glutamatergic synapse
A	0150104	biological_process	transport across blood-brain barrier
A	1901475	biological_process	pyruvate transmembrane transport
B	0005477	molecular_function	pyruvate secondary active transmembrane transporter activity
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008028	molecular_function	monocarboxylic acid transmembrane transporter activity
B	0015129	molecular_function	lactate transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015355	molecular_function	secondary active monocarboxylate transmembrane transporter activity
B	0015718	biological_process	monocarboxylic acid transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0035873	biological_process	lactate transmembrane transport
B	0035879	biological_process	plasma membrane lactate transport
B	0042802	molecular_function	identical protein binding
B	0050833	molecular_function	pyruvate transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
B	0098688	cellular_component	parallel fiber to Purkinje cell synapse
B	0098839	cellular_component	postsynaptic density membrane
B	0098978	cellular_component	glutamatergic synapse
B	0150104	biological_process	transport across blood-brain barrier
B	1901475	biological_process	pyruvate transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	80
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Site: {"description":"May be protonated during monocarboxylate transport","evidences":[{"source":"PubMed","id":"32415067","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)