7BLN

VPS35/VPS29 arch of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005765	cellular_component	lysosomal membrane
A	0005768	cellular_component	endosome
A	0005769	cellular_component	early endosome
A	0005770	cellular_component	late endosome
A	0005829	cellular_component	cytosol
A	0006886	biological_process	intracellular protein transport
A	0007040	biological_process	lysosome organization
A	0009967	biological_process	positive regulation of signal transduction
A	0010008	cellular_component	endosome membrane
A	0010628	biological_process	positive regulation of gene expression
A	0010629	biological_process	negative regulation of gene expression
A	0010821	biological_process	regulation of mitochondrion organization
A	0014069	cellular_component	postsynaptic density
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016055	biological_process	Wnt signaling pathway
A	0016241	biological_process	regulation of macroautophagy
A	0030904	cellular_component	retromer complex
A	0030906	cellular_component	retromer, cargo-selective complex
A	0031647	biological_process	regulation of protein stability
A	0031648	biological_process	protein destabilization
A	0031748	molecular_function	D1 dopamine receptor binding
A	0032456	biological_process	endocytic recycling
A	0032463	biological_process	negative regulation of protein homooligomerization
A	0036010	biological_process	protein localization to endosome
A	0042147	biological_process	retrograde transport, endosome to Golgi
A	0042176	biological_process	regulation of protein catabolic process
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
A	0045056	biological_process	transcytosis
A	0045202	cellular_component	synapse
A	0045732	biological_process	positive regulation of protein catabolic process
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050728	biological_process	negative regulation of inflammatory response
A	0050793	biological_process	regulation of developmental process
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0050882	biological_process	voluntary musculoskeletal movement
A	0051049	biological_process	regulation of transport
A	0051246	biological_process	regulation of protein metabolic process
A	0060161	biological_process	positive regulation of dopamine receptor signaling pathway
A	0061357	biological_process	positive regulation of Wnt protein secretion
A	0070062	cellular_component	extracellular exosome
A	0090128	biological_process	regulation of synapse maturation
A	0090141	biological_process	positive regulation of mitochondrial fission
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
A	0090326	biological_process	positive regulation of locomotion involved in locomotory behavior
A	0097422	cellular_component	tubular endosome
A	0098691	cellular_component	dopaminergic synapse
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098887	biological_process	neurotransmitter receptor transport, endosome to postsynaptic membrane
A	0098978	cellular_component	glutamatergic synapse
A	0099073	cellular_component	mitochondrion-derived vesicle
A	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
A	0099175	biological_process	regulation of postsynapse organization
A	0099639	biological_process	neurotransmitter receptor transport, endosome to plasma membrane
A	0150052	biological_process	regulation of postsynapse assembly
A	1902823	biological_process	negative regulation of late endosome to lysosome transport
A	1902950	biological_process	regulation of dendritic spine maintenance
A	1903181	biological_process	positive regulation of dopamine biosynthetic process
A	1903828	biological_process	negative regulation of protein localization
A	1903829	biological_process	positive regulation of protein localization
A	1904377	biological_process	positive regulation of protein localization to cell periphery
A	1905166	biological_process	negative regulation of lysosomal protein catabolic process
A	1905606	biological_process	regulation of presynapse assembly
A	2000331	biological_process	regulation of terminal button organization
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005768	cellular_component	endosome
B	0005769	cellular_component	early endosome
B	0005770	cellular_component	late endosome
B	0005829	cellular_component	cytosol
B	0006886	biological_process	intracellular protein transport
B	0010008	cellular_component	endosome membrane
B	0010506	biological_process	regulation of autophagy
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0030904	cellular_component	retromer complex
B	0030906	cellular_component	retromer, cargo-selective complex
B	0032456	biological_process	endocytic recycling
B	0032991	cellular_component	protein-containing complex
B	0042147	biological_process	retrograde transport, endosome to Golgi
B	0046872	molecular_function	metal ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005765	cellular_component	lysosomal membrane
C	0005768	cellular_component	endosome
C	0005769	cellular_component	early endosome
C	0005770	cellular_component	late endosome
C	0005829	cellular_component	cytosol
C	0006886	biological_process	intracellular protein transport
C	0007040	biological_process	lysosome organization
C	0009967	biological_process	positive regulation of signal transduction
C	0010008	cellular_component	endosome membrane
C	0010628	biological_process	positive regulation of gene expression
C	0010629	biological_process	negative regulation of gene expression
C	0010821	biological_process	regulation of mitochondrion organization
C	0014069	cellular_component	postsynaptic density
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0016055	biological_process	Wnt signaling pathway
C	0016241	biological_process	regulation of macroautophagy
C	0030904	cellular_component	retromer complex
C	0030906	cellular_component	retromer, cargo-selective complex
C	0031647	biological_process	regulation of protein stability
C	0031648	biological_process	protein destabilization
C	0031748	molecular_function	D1 dopamine receptor binding
C	0032456	biological_process	endocytic recycling
C	0032463	biological_process	negative regulation of protein homooligomerization
C	0036010	biological_process	protein localization to endosome
C	0042147	biological_process	retrograde transport, endosome to Golgi
C	0042176	biological_process	regulation of protein catabolic process
C	0043005	cellular_component	neuron projection
C	0043025	cellular_component	neuronal cell body
C	0043653	biological_process	mitochondrial fragmentation involved in apoptotic process
C	0045056	biological_process	transcytosis
C	0045202	cellular_component	synapse
C	0045732	biological_process	positive regulation of protein catabolic process
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050728	biological_process	negative regulation of inflammatory response
C	0050793	biological_process	regulation of developmental process
C	0050804	biological_process	modulation of chemical synaptic transmission
C	0050882	biological_process	voluntary musculoskeletal movement
C	0051049	biological_process	regulation of transport
C	0051246	biological_process	regulation of protein metabolic process
C	0060161	biological_process	positive regulation of dopamine receptor signaling pathway
C	0061357	biological_process	positive regulation of Wnt protein secretion
C	0070062	cellular_component	extracellular exosome
C	0090128	biological_process	regulation of synapse maturation
C	0090141	biological_process	positive regulation of mitochondrial fission
C	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
C	0090326	biological_process	positive regulation of locomotion involved in locomotory behavior
C	0097422	cellular_component	tubular endosome
C	0098691	cellular_component	dopaminergic synapse
C	0098793	cellular_component	presynapse
C	0098794	cellular_component	postsynapse
C	0098887	biological_process	neurotransmitter receptor transport, endosome to postsynaptic membrane
C	0098978	cellular_component	glutamatergic synapse
C	0099073	cellular_component	mitochondrion-derived vesicle
C	0099074	biological_process	mitochondrion to lysosome vesicle-mediated transport
C	0099175	biological_process	regulation of postsynapse organization
C	0099639	biological_process	neurotransmitter receptor transport, endosome to plasma membrane
C	0150052	biological_process	regulation of postsynapse assembly
C	1902823	biological_process	negative regulation of late endosome to lysosome transport
C	1902950	biological_process	regulation of dendritic spine maintenance
C	1903181	biological_process	positive regulation of dopamine biosynthetic process
C	1903828	biological_process	negative regulation of protein localization
C	1903829	biological_process	positive regulation of protein localization
C	1904377	biological_process	positive regulation of protein localization to cell periphery
C	1905166	biological_process	negative regulation of lysosomal protein catabolic process
C	1905606	biological_process	regulation of presynapse assembly
C	2000331	biological_process	regulation of terminal button organization
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005768	cellular_component	endosome
D	0005769	cellular_component	early endosome
D	0005770	cellular_component	late endosome
D	0005829	cellular_component	cytosol
D	0006886	biological_process	intracellular protein transport
D	0010008	cellular_component	endosome membrane
D	0010506	biological_process	regulation of autophagy
D	0015031	biological_process	protein transport
D	0016020	cellular_component	membrane
D	0030904	cellular_component	retromer complex
D	0030906	cellular_component	retromer, cargo-selective complex
D	0032456	biological_process	endocytic recycling
D	0032991	cellular_component	protein-containing complex
D	0042147	biological_process	retrograde transport, endosome to Golgi
D	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	58
Details	Region: {"description":"Interaction with SNX3","evidences":[{"source":"PubMed","id":"24344282","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	386
Details	Region: {"description":"Interaction with IGF2R cytoplasmic domain","evidences":[{"source":"PubMed","id":"15078903","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---