7BL7

Crystal structure of UMPK from M. tuberculosis in complex with UDP and UTP (P21212 form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006225	biological_process	UDP biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0033862	molecular_function	UMP kinase activity
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006225	biological_process	UDP biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0033862	molecular_function	UMP kinase activity
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0046940	biological_process	nucleoside monophosphate phosphorylation
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006225	biological_process	UDP biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0033862	molecular_function	UMP kinase activity
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0046940	biological_process	nucleoside monophosphate phosphorylation
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006225	biological_process	UDP biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0033862	molecular_function	UMP kinase activity
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0046940	biological_process	nucleoside monophosphate phosphorylation
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006225	biological_process	UDP biosynthetic process
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0033862	molecular_function	UMP kinase activity
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0046940	biological_process	nucleoside monophosphate phosphorylation
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006225	biological_process	UDP biosynthetic process
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0033862	molecular_function	UMP kinase activity
F	0044210	biological_process	'de novo' CTP biosynthetic process
F	0046940	biological_process	nucleoside monophosphate phosphorylation
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006225	biological_process	UDP biosynthetic process
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0033862	molecular_function	UMP kinase activity
G	0044210	biological_process	'de novo' CTP biosynthetic process
G	0046940	biological_process	nucleoside monophosphate phosphorylation
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006225	biological_process	UDP biosynthetic process
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0033862	molecular_function	UMP kinase activity
H	0044210	biological_process	'de novo' CTP biosynthetic process
H	0046940	biological_process	nucleoside monophosphate phosphorylation
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006221	biological_process	pyrimidine nucleotide biosynthetic process
I	0006225	biological_process	UDP biosynthetic process
I	0016301	molecular_function	kinase activity
I	0016740	molecular_function	transferase activity
I	0033862	molecular_function	UMP kinase activity
I	0044210	biological_process	'de novo' CTP biosynthetic process
I	0046940	biological_process	nucleoside monophosphate phosphorylation
J	0000166	molecular_function	nucleotide binding
J	0000287	molecular_function	magnesium ion binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006221	biological_process	pyrimidine nucleotide biosynthetic process
J	0006225	biological_process	UDP biosynthetic process
J	0016301	molecular_function	kinase activity
J	0016740	molecular_function	transferase activity
J	0033862	molecular_function	UMP kinase activity
J	0044210	biological_process	'de novo' CTP biosynthetic process
J	0046940	biological_process	nucleoside monophosphate phosphorylation
K	0000166	molecular_function	nucleotide binding
K	0000287	molecular_function	magnesium ion binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006221	biological_process	pyrimidine nucleotide biosynthetic process
K	0006225	biological_process	UDP biosynthetic process
K	0016301	molecular_function	kinase activity
K	0016740	molecular_function	transferase activity
K	0033862	molecular_function	UMP kinase activity
K	0044210	biological_process	'de novo' CTP biosynthetic process
K	0046940	biological_process	nucleoside monophosphate phosphorylation
L	0000166	molecular_function	nucleotide binding
L	0000287	molecular_function	magnesium ion binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006221	biological_process	pyrimidine nucleotide biosynthetic process
L	0006225	biological_process	UDP biosynthetic process
L	0016301	molecular_function	kinase activity
L	0016740	molecular_function	transferase activity
L	0033862	molecular_function	UMP kinase activity
L	0044210	biological_process	'de novo' CTP biosynthetic process
L	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue UDP B 301

Chain	Residue
B	LYS36
B	GLY100
B	MET101
B	GLY157
B	MET158
B	LEU160
B	PHE163
B	SER164
B	THR165
B	THR168
B	GLY38
B	GLY39
B	GLY76
B	GLY77
B	GLY78
B	ARG82
B	GLY83
B	ASP97

---

site_id	AC2
Number of Residues	12
Details	binding site for residue UTP A 301

Chain	Residue
A	ARG123
A	GLY131
A	ALA134
A	GLU135
A	ARG141
A	HIS145
A	LYS148
C	LEU140
C	ARG141
C	ARG144
C	LYS148
C	UTP301

---

site_id	AC3
Number of Residues	10
Details	binding site for residue UTP F 301

Chain	Residue
D	LEU140
D	ARG141
D	ARG144
D	LYS148
F	ARG123
F	GLY131
F	ALA134
F	GLU135
F	LYS148
F	ARG150

---

site_id	AC4
Number of Residues	18
Details	binding site for residue UDP E 301

Chain	Residue
E	LYS36
E	GLY38
E	GLY39
E	GLY76
E	GLY77
E	GLY78
E	ARG82
E	GLY83
E	ASP97
E	GLY100
E	MET101
E	GLY157
E	MET158
E	LEU160
E	PRO161
E	PHE163
E	THR165
E	THR168

---

site_id	AC5
Number of Residues	13
Details	binding site for residue UTP D 301

Chain	Residue
B	LEU138
B	LEU140
B	ARG141
B	ARG144
B	LYS148
D	ARG123
D	GLY131
D	ALA134
D	GLU135
D	ARG141
D	HIS145
D	LYS148
D	ARG150

---

site_id	AC6
Number of Residues	15
Details	binding site for residue UDP D 302

Chain	Residue
D	LYS36
D	GLY38
D	GLY39
D	GLY76
D	GLY77
D	GLY78
D	ARG82
D	GLY83
D	ASP97
D	GLY100
D	MET101
D	MET158
D	LEU160
D	PHE163
D	THR165

---

site_id	AC7
Number of Residues	13
Details	binding site for residue UTP C 301

Chain	Residue
A	UTP301
C	ARG123
C	VAL124
C	GLY131
C	GLU135
C	ARG141
C	LYS148
C	ARG150
E	LEU138
E	LEU140
E	ARG141
E	ARG144
E	LYS148

---

site_id	AC8
Number of Residues	16
Details	binding site for residue UDP C 302

Chain	Residue
C	LYS36
C	GLY38
C	GLY39
C	GLY77
C	GLY78
C	ARG82
C	GLY83
C	ASP97
C	MET101
C	GLY157
C	MET158
C	LEU160
C	PRO161
C	PHE163
C	SER164
C	THR165

---

site_id	AC9
Number of Residues	13
Details	binding site for residue UTP I 301

Chain	Residue
G	UTP301
I	ARG123
I	VAL124
I	GLY131
I	GLU135
I	ARG141
I	LYS148
I	ARG150
K	LEU138
K	LEU140
K	ARG141
K	ARG144
K	LYS148

---

site_id	AD1
Number of Residues	15
Details	binding site for residue UDP I 302

Chain	Residue
I	LYS36
I	GLY38
I	GLY39
I	GLY77
I	GLY78
I	ARG82
I	GLY83
I	ASP97
I	GLY100
I	MET101
I	GLY157
I	MET158
I	LEU160
I	PHE163
I	THR165

---

site_id	AD2
Number of Residues	13
Details	binding site for residue UTP J 301

Chain	Residue
H	LEU140
H	ARG141
H	ARG144
H	LYS148
J	ARG123
J	GLY131
J	GLU135
J	ARG141
J	HIS145
J	LYS148
J	ARG150
L	ARG141
L	UTP301

---

site_id	AD3
Number of Residues	17
Details	binding site for residue UDP J 302

Chain	Residue
J	LYS36
J	GLY38
J	GLY39
J	GLY77
J	GLY78
J	ARG82
J	GLY83
J	ASP97
J	MET101
J	GLY157
J	MET158
J	GLY159
J	LEU160
J	PHE163
J	SER164
J	THR165
J	THR168

---

site_id	AD4
Number of Residues	16
Details	binding site for residue UDP K 301

Chain	Residue
K	LYS36
K	GLY38
K	GLY39
K	GLY77
K	GLY78
K	ARG82
K	GLY83
K	ASP97
K	GLY100
K	MET101
K	GLY157
K	MET158
K	LEU160
K	PHE163
K	THR165
K	THR168

---

site_id	AD5
Number of Residues	12
Details	binding site for residue UTP L 301

Chain	Residue
J	LEU140
J	ARG141
J	ARG144
J	LYS148
J	UTP301
L	ARG123
L	GLY131
L	GLU135
L	ARG141
L	HIS145
L	LYS148
L	ARG150

---

site_id	AD6
Number of Residues	13
Details	binding site for residue UTP G 301

Chain	Residue
G	ARG123
G	GLY131
G	GLU135
G	ARG141
G	HIS145
G	LYS148
G	ARG150
G	HOH401
I	LEU140
I	ARG141
I	ARG144
I	LYS148
I	UTP301

---

site_id	AD7
Number of Residues	15
Details	binding site for residue UDP H 301

Chain	Residue
H	LYS36
H	GLY39
H	GLY76
H	GLY77
H	GLY78
H	ARG82
H	GLY83
H	ASP97
H	GLY100
H	MET101
H	GLY157
H	MET158
H	LEU160
H	PHE163
H	THR165

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	166
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01220","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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