7BL1

human complex II-BATS bound to membrane-attached Rab5a-GTP

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000149	molecular_function	SNARE binding
AAA	0000323	cellular_component	lytic vacuole
AAA	0000421	cellular_component	autophagosome membrane
AAA	0000775	cellular_component	chromosome, centromeric region
AAA	0005515	molecular_function	protein binding
AAA	0005694	cellular_component	chromosome
AAA	0005737	cellular_component	cytoplasm
AAA	0005764	cellular_component	lysosome
AAA	0005768	cellular_component	endosome
AAA	0005769	cellular_component	early endosome
AAA	0005770	cellular_component	late endosome
AAA	0005776	cellular_component	autophagosome
AAA	0005783	cellular_component	endoplasmic reticulum
AAA	0005813	cellular_component	centrosome
AAA	0006281	biological_process	DNA repair
AAA	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
AAA	0006914	biological_process	autophagy
AAA	0007051	biological_process	spindle organization
AAA	0007059	biological_process	chromosome segregation
AAA	0007098	biological_process	centrosome cycle
AAA	0010506	biological_process	regulation of autophagy
AAA	0017124	molecular_function	SH3 domain binding
AAA	0030496	cellular_component	midbody
AAA	0032465	biological_process	regulation of cytokinesis
AAA	0032801	biological_process	receptor catabolic process
AAA	0032991	cellular_component	protein-containing complex
AAA	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
AAA	0035032	cellular_component	phosphatidylinositol 3-kinase complex, class III
AAA	0035493	biological_process	SNARE complex assembly
AAA	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
AAA	0045335	cellular_component	phagocytic vesicle
AAA	0046718	biological_process	symbiont entry into host cell
AAA	0051684	biological_process	maintenance of Golgi location
AAA	0070418	cellular_component	DNA-dependent protein kinase complex
AAA	0071900	biological_process	regulation of protein serine/threonine kinase activity
AAA	0071985	biological_process	multivesicular body sorting pathway
AAA	0097352	biological_process	autophagosome maturation
AAA	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
AAA	1901098	biological_process	positive regulation of autophagosome maturation
BBB	0000045	biological_process	autophagosome assembly
BBB	0000407	cellular_component	phagophore assembly site
BBB	0004672	molecular_function	protein kinase activity
BBB	0005515	molecular_function	protein binding
BBB	0005524	molecular_function	ATP binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005768	cellular_component	endosome
BBB	0005770	cellular_component	late endosome
BBB	0005776	cellular_component	autophagosome
BBB	0005777	cellular_component	peroxisome
BBB	0005829	cellular_component	cytosol
BBB	0005930	cellular_component	axoneme
BBB	0006497	biological_process	protein lipidation
BBB	0006622	biological_process	protein targeting to lysosome
BBB	0006629	biological_process	lipid metabolic process
BBB	0006897	biological_process	endocytosis
BBB	0006914	biological_process	autophagy
BBB	0009267	biological_process	cellular response to starvation
BBB	0010506	biological_process	regulation of autophagy
BBB	0016020	cellular_component	membrane
BBB	0016236	biological_process	macroautophagy
BBB	0016241	biological_process	regulation of macroautophagy
BBB	0016301	molecular_function	kinase activity
BBB	0016303	molecular_function	1-phosphatidylinositol-3-kinase activity
BBB	0030242	biological_process	autophagy of peroxisome
BBB	0030496	cellular_component	midbody
BBB	0030670	cellular_component	phagocytic vesicle membrane
BBB	0032465	biological_process	regulation of cytokinesis
BBB	0034271	cellular_component	phosphatidylinositol 3-kinase complex, class III, type I
BBB	0034272	cellular_component	phosphatidylinositol 3-kinase complex, class III, type II
BBB	0034497	biological_process	protein localization to phagophore assembly site
BBB	0035032	cellular_component	phosphatidylinositol 3-kinase complex, class III
BBB	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
BBB	0042149	biological_process	cellular response to glucose starvation
BBB	0044754	cellular_component	autolysosome
BBB	0044829	biological_process	positive regulation by host of viral genome replication
BBB	0045022	biological_process	early endosome to late endosome transport
BBB	0045335	cellular_component	phagocytic vesicle
BBB	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
BBB	0048015	biological_process	phosphatidylinositol-mediated signaling
BBB	0051301	biological_process	cell division
BBB	0052742	molecular_function	phosphatidylinositol kinase activity
BBB	0097352	biological_process	autophagosome maturation
CCC	0004672	molecular_function	protein kinase activity
CCC	0004674	molecular_function	protein serine/threonine kinase activity
CCC	0005515	molecular_function	protein binding
CCC	0005524	molecular_function	ATP binding
CCC	0005768	cellular_component	endosome
CCC	0005770	cellular_component	late endosome
CCC	0005776	cellular_component	autophagosome
CCC	0005829	cellular_component	cytosol
CCC	0005930	cellular_component	axoneme
CCC	0006468	biological_process	protein phosphorylation
CCC	0006622	biological_process	protein targeting to lysosome
CCC	0006623	biological_process	protein targeting to vacuole
CCC	0010506	biological_process	regulation of autophagy
CCC	0015630	cellular_component	microtubule cytoskeleton
CCC	0016020	cellular_component	membrane
CCC	0016236	biological_process	macroautophagy
CCC	0016241	biological_process	regulation of macroautophagy
CCC	0030242	biological_process	autophagy of peroxisome
CCC	0030670	cellular_component	phagocytic vesicle membrane
CCC	0032465	biological_process	regulation of cytokinesis
CCC	0032801	biological_process	receptor catabolic process
CCC	0034271	cellular_component	phosphatidylinositol 3-kinase complex, class III, type I
CCC	0034272	cellular_component	phosphatidylinositol 3-kinase complex, class III, type II
CCC	0035032	cellular_component	phosphatidylinositol 3-kinase complex, class III
CCC	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
CCC	0042149	biological_process	cellular response to glucose starvation
CCC	0043231	cellular_component	intracellular membrane-bounded organelle
CCC	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
CCC	0045022	biological_process	early endosome to late endosome transport
CCC	0045324	biological_process	late endosome to vacuole transport
CCC	0071561	cellular_component	nucleus-vacuole junction
CCC	0097352	biological_process	autophagosome maturation
CCC	0106310	molecular_function	protein serine kinase activity
DDD	0003924	molecular_function	GTPase activity
DDD	0005525	molecular_function	GTP binding
EEE	0000045	biological_process	autophagosome assembly
EEE	0000407	cellular_component	phagophore assembly site
EEE	0000423	biological_process	mitophagy
EEE	0001666	biological_process	response to hypoxia
EEE	0002753	biological_process	cytoplasmic pattern recognition receptor signaling pathway
EEE	0005515	molecular_function	protein binding
EEE	0005634	cellular_component	nucleus
EEE	0005737	cellular_component	cytoplasm
EEE	0005739	cellular_component	mitochondrion
EEE	0005768	cellular_component	endosome
EEE	0005776	cellular_component	autophagosome
EEE	0005783	cellular_component	endoplasmic reticulum
EEE	0005789	cellular_component	endoplasmic reticulum membrane
EEE	0005794	cellular_component	Golgi apparatus
EEE	0005802	cellular_component	trans-Golgi network
EEE	0005829	cellular_component	cytosol
EEE	0006622	biological_process	protein targeting to lysosome
EEE	0006897	biological_process	endocytosis
EEE	0006914	biological_process	autophagy
EEE	0006915	biological_process	apoptotic process
EEE	0006968	biological_process	cellular defense response
EEE	0006995	biological_process	cellular response to nitrogen starvation
EEE	0007040	biological_process	lysosome organization
EEE	0007080	biological_process	mitotic metaphase chromosome alignment
EEE	0007254	biological_process	JNK cascade
EEE	0008285	biological_process	negative regulation of cell population proliferation
EEE	0009410	biological_process	response to xenobiotic stimulus
EEE	0010008	cellular_component	endosome membrane
EEE	0010040	biological_process	response to iron(II) ion
EEE	0010288	biological_process	response to lead ion
EEE	0010506	biological_process	regulation of autophagy
EEE	0010507	biological_process	negative regulation of autophagy
EEE	0010508	biological_process	positive regulation of autophagy
EEE	0010613	biological_process	positive regulation of cardiac muscle hypertrophy
EEE	0016020	cellular_component	membrane
EEE	0016236	biological_process	macroautophagy
EEE	0016241	biological_process	regulation of macroautophagy
EEE	0016604	cellular_component	nuclear body
EEE	0019901	molecular_function	protein kinase binding
EEE	0030425	cellular_component	dendrite
EEE	0030674	molecular_function	protein-macromolecule adaptor activity
EEE	0031410	cellular_component	cytoplasmic vesicle
EEE	0031625	molecular_function	ubiquitin protein ligase binding
EEE	0031667	biological_process	response to nutrient levels
EEE	0031966	cellular_component	mitochondrial membrane
EEE	0032465	biological_process	regulation of cytokinesis
EEE	0032473	cellular_component	cytoplasmic side of mitochondrial outer membrane
EEE	0032801	biological_process	receptor catabolic process
EEE	0032991	cellular_component	protein-containing complex
EEE	0033197	biological_process	response to vitamin E
EEE	0034198	biological_process	cellular response to amino acid starvation
EEE	0034271	cellular_component	phosphatidylinositol 3-kinase complex, class III, type I
EEE	0034272	cellular_component	phosphatidylinositol 3-kinase complex, class III, type II
EEE	0035032	cellular_component	phosphatidylinositol 3-kinase complex, class III
EEE	0036092	biological_process	phosphatidylinositol-3-phosphate biosynthetic process
EEE	0038066	biological_process	p38MAPK cascade
EEE	0039521	biological_process	suppression by virus of host autophagy
EEE	0042149	biological_process	cellular response to glucose starvation
EEE	0042802	molecular_function	identical protein binding
EEE	0043066	biological_process	negative regulation of apoptotic process
EEE	0043069	biological_process	negative regulation of programmed cell death
EEE	0043548	molecular_function	phosphatidylinositol 3-kinase binding
EEE	0043652	biological_process	engulfment of apoptotic cell
EEE	0045022	biological_process	early endosome to late endosome transport
EEE	0045324	biological_process	late endosome to vacuole transport
EEE	0045335	cellular_component	phagocytic vesicle
EEE	0048666	biological_process	neuron development
EEE	0050435	biological_process	amyloid-beta metabolic process
EEE	0051020	molecular_function	GTPase binding
EEE	0051301	biological_process	cell division
EEE	0051607	biological_process	defense response to virus
EEE	0051707	biological_process	response to other organism
EEE	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
EEE	0060090	molecular_function	molecular adaptor activity
EEE	0060395	biological_process	SMAD protein signal transduction
EEE	0062029	biological_process	positive regulation of stress granule assembly
EEE	0065003	biological_process	protein-containing complex assembly
EEE	0070301	biological_process	cellular response to hydrogen peroxide
EEE	0071275	biological_process	cellular response to aluminum ion
EEE	0071280	biological_process	cellular response to copper ion
EEE	0071364	biological_process	cellular response to epidermal growth factor stimulus
EEE	0090650	biological_process	cellular response to oxygen-glucose deprivation
EEE	0097352	biological_process	autophagosome maturation
EEE	0098780	biological_process	response to mitochondrial depolarisation
EEE	1902425	biological_process	positive regulation of attachment of mitotic spindle microtubules to kinetochore
EEE	1902902	biological_process	negative regulation of autophagosome assembly
EEE	1905672	biological_process	negative regulation of lysosome organization
EEE	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
EEE	2000786	biological_process	positive regulation of autophagosome assembly
EEE	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VrHgDIKteNVMV

Chain	Residue	Details
CCC	VAL144-VAL156

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IAAVqgNnEVSMWDM

Chain	Residue	Details
CCC	ILE1201-MET1215
CCC	LEU1256-LEU1270

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site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDqlilQ

Chain	Residue	Details
BBB	PHE635-GLN649

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site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVitYILgVgDRHldN

Chain	Residue	Details
BBB	SER728-ASN748

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:12433916, ECO:0000269|PubMed:14684892, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:20534488, ECO:0007744|PDB:1N6H, ECO:0007744|PDB:1N6L, ECO:0007744|PDB:1N6N, ECO:0007744|PDB:1N6O, ECO:0007744|PDB:1N6P, ECO:0007744|PDB:1N6R, ECO:0007744|PDB:1R2Q, ECO:0007744|PDB:1TU3, ECO:0007744|PDB:3MJH

Chain	Residue	Details
DDD	GLY27
DDD	HIS46
DDD	ASP75
DDD	ASN133
DDD	SER163

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by LRRK2 => ECO:0000269|PubMed:29125462

Chain	Residue	Details
DDD	SER84
CCC	LYS53

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: (Microbial infection) N-beta-linked (GlcNAc) arginine => ECO:0000269|PubMed:32974215

Chain	Residue	Details
DDD	ARG120
CCC	SER853
CCC	SER865

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:23878393

Chain	Residue	Details
EEE	SER90

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:23878393, ECO:0000269|PubMed:25891078

Chain	Residue	Details
EEE	SER93

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:25891078

Chain	Residue	Details
EEE	SER96

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by DAPK1 => ECO:0000269|PubMed:19180116

Chain	Residue	Details
EEE	THR119

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site_id	SWS_FT_FI8
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:28445460

Chain	Residue	Details
EEE	LYS402

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site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23974797

Chain	Residue	Details
EEE	LYS437

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