7B2M
Cryo-EM structure of complement C4b in complex with nanobody E3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004866 | molecular_function | endopeptidase inhibitor activity |
| B | 0004866 | molecular_function | endopeptidase inhibitor activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006954 | biological_process | inflammatory response |
| B | 0006956 | biological_process | complement activation |
| C | 0005576 | cellular_component | extracellular region |
Functional Information from PROSITE/UniProt
| site_id | PS00477 |
| Number of Residues | 9 |
| Details | ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PrGCGEQtM |
| Chain | Residue | Details |
| B | PRO1007-MET1015 |
| site_id | PS01177 |
| Number of Residues | 35 |
| Details | ANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCqdGvtrlpmmrSCEqraarvq..QpdCrepfls.CC |
| Chain | Residue | Details |
| B | CYS702-CYS736 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Responsible for effective binding to form amide bonds with immune aggregates or protein antigens |
| Chain | Residue | Details |
| B | ASP1125 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039 |
| Chain | Residue | Details |
| B | SER918 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:3944109 |
| Chain | Residue | Details |
| B | TYR1417 | |
| B | TYR1420 | |
| B | TYR1422 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| B | ASN862 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:23234360 |
| Chain | Residue | Details |
| B | THR1244 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| B | ASN1328 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| B | ASN1391 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln) |
| Chain | Residue | Details |
| B | CYS1010 | |
| B | GLN1013 |
