Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7AYZ

Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with activator TH10785

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AAA0000702molecular_functionoxidized base lesion DNA N-glycosylase activity
AAA0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
AAA0003677molecular_functionDNA binding
AAA0003684molecular_functiondamaged DNA binding
AAA0003824molecular_functioncatalytic activity
AAA0005634cellular_componentnucleus
AAA0005654cellular_componentnucleoplasm
AAA0005739cellular_componentmitochondrion
AAA0006281biological_processDNA repair
AAA0006284biological_processbase-excision repair
AAA0006285biological_processbase-excision repair, AP site formation
AAA0006289biological_processnucleotide-excision repair
AAA0006355biological_processregulation of DNA-templated transcription
AAA0006974biological_processDNA damage response
AAA0006979biological_processresponse to oxidative stress
AAA0008017molecular_functionmicrotubule binding
AAA0008534molecular_functionoxidized purine nucleobase lesion DNA N-glycosylase activity
AAA0009314biological_processresponse to radiation
AAA0009410biological_processresponse to xenobiotic stimulus
AAA0009416biological_processresponse to light stimulus
AAA0016363cellular_componentnuclear matrix
AAA0016607cellular_componentnuclear speck
AAA0016798molecular_functionhydrolase activity, acting on glycosyl bonds
AAA0016829molecular_functionlyase activity
AAA0019104molecular_functionDNA N-glycosylase activity
AAA0019899molecular_functionenzyme binding
AAA0032355biological_processresponse to estradiol
AAA0032357molecular_functionoxidized purine DNA binding
AAA0032991cellular_componentprotein-containing complex
AAA0034039molecular_function8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
AAA0034614biological_processcellular response to reactive oxygen species
AAA0043066biological_processnegative regulation of apoptotic process
AAA0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
AAA0045471biological_processresponse to ethanol
AAA0045944biological_processpositive regulation of transcription by RNA polymerase II
AAA0051593biological_processresponse to folic acid
AAA0071276biological_processcellular response to cadmium ion
AAA0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
AAA0140097molecular_functioncatalytic activity, acting on DNA
AAA1901291biological_processnegative regulation of double-strand break repair via single-strand annealing
BBB0000702molecular_functionoxidized base lesion DNA N-glycosylase activity
BBB0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
BBB0003677molecular_functionDNA binding
BBB0003684molecular_functiondamaged DNA binding
BBB0003824molecular_functioncatalytic activity
BBB0005634cellular_componentnucleus
BBB0005654cellular_componentnucleoplasm
BBB0005739cellular_componentmitochondrion
BBB0006281biological_processDNA repair
BBB0006284biological_processbase-excision repair
BBB0006285biological_processbase-excision repair, AP site formation
BBB0006289biological_processnucleotide-excision repair
BBB0006355biological_processregulation of DNA-templated transcription
BBB0006974biological_processDNA damage response
BBB0006979biological_processresponse to oxidative stress
BBB0008017molecular_functionmicrotubule binding
BBB0008534molecular_functionoxidized purine nucleobase lesion DNA N-glycosylase activity
BBB0009314biological_processresponse to radiation
BBB0009410biological_processresponse to xenobiotic stimulus
BBB0009416biological_processresponse to light stimulus
BBB0016363cellular_componentnuclear matrix
BBB0016607cellular_componentnuclear speck
BBB0016798molecular_functionhydrolase activity, acting on glycosyl bonds
BBB0016829molecular_functionlyase activity
BBB0019104molecular_functionDNA N-glycosylase activity
BBB0019899molecular_functionenzyme binding
BBB0032355biological_processresponse to estradiol
BBB0032357molecular_functionoxidized purine DNA binding
BBB0032991cellular_componentprotein-containing complex
BBB0034039molecular_function8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
BBB0034614biological_processcellular response to reactive oxygen species
BBB0043066biological_processnegative regulation of apoptotic process
BBB0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
BBB0045471biological_processresponse to ethanol
BBB0045944biological_processpositive regulation of transcription by RNA polymerase II
BBB0051593biological_processresponse to folic acid
BBB0071276biological_processcellular response to cadmium ion
BBB0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
BBB0140097molecular_functioncatalytic activity, acting on DNA
BBB1901291biological_processnegative regulation of double-strand break repair via single-strand annealing
CCC0000702molecular_functionoxidized base lesion DNA N-glycosylase activity
CCC0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
CCC0003677molecular_functionDNA binding
CCC0003684molecular_functiondamaged DNA binding
CCC0003824molecular_functioncatalytic activity
CCC0005634cellular_componentnucleus
CCC0005654cellular_componentnucleoplasm
CCC0005739cellular_componentmitochondrion
CCC0006281biological_processDNA repair
CCC0006284biological_processbase-excision repair
CCC0006285biological_processbase-excision repair, AP site formation
CCC0006289biological_processnucleotide-excision repair
CCC0006355biological_processregulation of DNA-templated transcription
CCC0006974biological_processDNA damage response
CCC0006979biological_processresponse to oxidative stress
CCC0008017molecular_functionmicrotubule binding
CCC0008534molecular_functionoxidized purine nucleobase lesion DNA N-glycosylase activity
CCC0009314biological_processresponse to radiation
CCC0009410biological_processresponse to xenobiotic stimulus
CCC0009416biological_processresponse to light stimulus
CCC0016363cellular_componentnuclear matrix
CCC0016607cellular_componentnuclear speck
CCC0016798molecular_functionhydrolase activity, acting on glycosyl bonds
CCC0016829molecular_functionlyase activity
CCC0019104molecular_functionDNA N-glycosylase activity
CCC0019899molecular_functionenzyme binding
CCC0032355biological_processresponse to estradiol
CCC0032357molecular_functionoxidized purine DNA binding
CCC0032991cellular_componentprotein-containing complex
CCC0034039molecular_function8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
CCC0034614biological_processcellular response to reactive oxygen species
CCC0043066biological_processnegative regulation of apoptotic process
CCC0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
CCC0045471biological_processresponse to ethanol
CCC0045944biological_processpositive regulation of transcription by RNA polymerase II
CCC0051593biological_processresponse to folic acid
CCC0071276biological_processcellular response to cadmium ion
CCC0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
CCC0140097molecular_functioncatalytic activity, acting on DNA
CCC1901291biological_processnegative regulation of double-strand break repair via single-strand annealing
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Schiff-base intermediate with DNA => ECO:0000250
ChainResidueDetails
AAALYS249
BBBLYS249
CCCLYS249

site_idSWS_FT_FI2
Number of Residues27
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AAAASN149
AAAARG154
AAAARG204
BBBGLN287
BBBGLN315
BBBPHE319
CCCASN149
CCCARG154
CCCARG204
CCCPRO266
CCCASP268
CCCHIS270
CCCGLN287
CCCGLN315
CCCPHE319
AAAPRO266
AAAASP268
AAAHIS270
AAAGLN287
AAAGLN315
AAAPHE319
BBBASN149
BBBARG154
BBBARG204
BBBPRO266
BBBASP268
BBBHIS270

219869

PDB entries from 2024-05-15

PDB statisticsPDBj update infoContact PDBjnumon