7AYC

Crystal Structure of human mitochondrial 2-Enoyl Thioester Reductase (MECR) with single mutation G165Q

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 402

Chain	Residue
A	LYS229
A	HIS235
A	VAL236
A	ARG244

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site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 403

Chain	Residue
A	ALA191
A	VAL215
A	ARG216
A	GLU239

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q8WZM3

Chain	Residue	Details
A	TYR94

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q8WZM3

Chain	Residue	Details
A	ASN193
A	ARG216
A	TYR285
A	PHE310
A	LYS368
A	ASN167

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site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9DCS3

Chain	Residue	Details
A	LYS267
A	LYS61
A	LYS252

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9DCS3

Chain	Residue	Details
A	LYS316

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