Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | LYS77 |
| A | ARG80 |
| A | ARG155 |
| A | ASN189 |
| A | HOH530 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ARG191 |
| A | LYS198 |
| A | ASN238 |
| A | HOH519 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | TRP33 |
| A | LYS75 |
| A | LYS102 |
| A | HOH528 |
| A | HOH535 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | LYS279 |
| A | ARG280 |
| A | GLU282 |
| A | ARG283 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | LYS75 |
| A | LYS102 |
| A | ARG107 |
| B | LYS74 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 406 |
| Chain | Residue |
| A | GLY48 |
| A | LYS49 |
| A | TYR50 |
| A | S8W419 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | HIS276 |
| A | SER277 |
| A | LYS279 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | GLN36 |
| A | TYR39 |
| A | VAL101 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 409 |
| Chain | Residue |
| A | ARG8 |
| A | ALA9 |
| A | ARG10 |
| A | ASP210 |
| A | SER212 |
| A | HIS309 |
| A | GLN310 |
| A | ARG312 |
| A | HOH525 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | ASP25 |
| A | TYR26 |
| A | GLU27 |
| A | HOH549 |
| A | HOH566 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | ASP299 |
| A | LYS303 |
| B | PRO295 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 412 |
| Chain | Residue |
| A | HIS160 |
| A | ASN161 |
| A | S8W419 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 413 |
| Chain | Residue |
| A | PRO6 |
| A | SER7 |
| A | ARG8 |
| A | GLY185 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 414 |
| Chain | Residue |
| A | VAL11 |
| A | TYR12 |
| A | ARG316 |
| A | HOH516 |
| A | HOH546 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 415 |
| Chain | Residue |
| A | TRP281 |
| A | LEU298 |
| A | HOH568 |
| B | HOH530 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 416 |
| Chain | Residue |
| A | ASP130 |
| A | ARG134 |
| A | THR326 |
| A | HOH541 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 417 |
| Chain | Residue |
| A | LYS77 |
| A | GLU81 |
| A | GLY177 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 418 |
| Chain | Residue |
| A | VAL248 |
| A | LEU249 |
| A | ARG278 |
| A | LYS279 |
| A | TRP281 |
| A | ASP302 |
| B | ARG278 |
| site_id | AE1 |
| Number of Residues | 15 |
| Details | binding site for residue S8W A 419 |
| Chain | Residue |
| A | SER51 |
| A | VAL53 |
| A | VAL66 |
| A | LYS68 |
| A | PHE113 |
| A | GLU114 |
| A | HIS115 |
| A | VAL116 |
| A | ASN118 |
| A | MET163 |
| A | ASP175 |
| A | SO4406 |
| A | EDO412 |
| A | HOH557 |
| A | HOH560 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | LYS77 |
| B | ARG80 |
| B | ARG155 |
| B | ASN189 |
| B | HOH528 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | LYS229 |
| B | HIS234 |
| B | ARG244 |
| B | EDO410 |
| B | HOH517 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | TRP33 |
| B | LYS75 |
| B | LYS102 |
| B | SO4404 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| A | ARG47 |
| B | LYS75 |
| B | LYS102 |
| B | SO4403 |
| B | HOH585 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | ASP25 |
| B | TYR26 |
| B | GLU27 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 406 |
| Chain | Residue |
| A | ASP299 |
| A | ASP302 |
| A | LYS303 |
| A | ARG306 |
| B | TRP281 |
| B | GLU282 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 407 |
| Chain | Residue |
| B | HIS276 |
| B | SER277 |
| B | LYS279 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 408 |
| Chain | Residue |
| B | ARG191 |
| B | LYS198 |
| B | ASN238 |
| site_id | AF1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 409 |
| Chain | Residue |
| B | ARG8 |
| B | ALA9 |
| B | ARG10 |
| B | VAL11 |
| B | ASP210 |
| B | TYR211 |
| B | HOH510 |
| B | HOH580 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 410 |
| Chain | Residue |
| B | LYS229 |
| B | PHE232 |
| B | PHE284 |
| B | SO4402 |
| B | HOH517 |
| site_id | AF3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 411 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 412 |
| Chain | Residue |
| B | TYR131 |
| B | ASP132 |
| B | PHE135 |
| B | ARG169 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 413 |
| Chain | Residue |
| A | VAL293 |
| A | LEU298 |
| B | ASP299 |
| B | LYS303 |
| B | HOH537 |
| site_id | AF6 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 414 |
| site_id | AF7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 415 |
| Chain | Residue |
| B | ARG278 |
| B | ARG280 |
| site_id | AF8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 416 |
| Chain | Residue |
| A | SER277 |
| A | ARG278 |
| B | GLU252 |
| B | SER277 |
| B | ARG278 |
| B | HOH579 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 417 |
| Chain | Residue |
| A | GLU32 |
| A | TRP33 |
| B | TYR196 |
| B | HIS234 |
| site_id | AG1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 418 |
| Chain | Residue |
| B | LYS170 |
| B | ARG172 |
| site_id | AG2 |
| Number of Residues | 13 |
| Details | binding site for residue S8W B 419 |
| Chain | Residue |
| B | SER51 |
| B | VAL53 |
| B | VAL66 |
| B | LYS68 |
| B | ILE95 |
| B | PHE113 |
| B | GLU114 |
| B | VAL116 |
| B | ASN118 |
| B | MET163 |
| B | ASP175 |
| B | HOH556 |
| B | HOH570 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK |
| Chain | Residue | Details |
| A | LEU45-LYS68 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
| Chain | Residue | Details |
| A | ILE152-ILE164 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 285 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Region: {"description":"Interaction with beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
