Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

7AX1

Crystal structure of the human CCR4-CAF1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000175molecular_function3'-5'-RNA exonuclease activity
A0000289biological_processnuclear-transcribed mRNA poly(A) tail shortening
A0003713molecular_functiontranscription coactivator activity
A0003723molecular_functionRNA binding
A0003824molecular_functioncatalytic activity
A0004518molecular_functionnuclease activity
A0004527molecular_functionexonuclease activity
A0004532molecular_functionRNA exonuclease activity
A0004535molecular_functionpoly(A)-specific ribonuclease activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006417biological_processregulation of translation
A0008284biological_processpositive regulation of cell population proliferation
A0010606biological_processpositive regulation of cytoplasmic mRNA processing body assembly
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0030014cellular_componentCCR4-NOT complex
A0031047biological_processregulatory ncRNA-mediated gene silencing
A0035279biological_processmiRNA-mediated gene silencing by mRNA destabilization
A0045893biological_processpositive regulation of DNA-templated transcription
A0046872molecular_functionmetal ion binding
A0070966biological_processnuclear-transcribed mRNA catabolic process, no-go decay
B0000175molecular_function3'-5'-RNA exonuclease activity
B0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
B0000289biological_processnuclear-transcribed mRNA poly(A) tail shortening
B0000290biological_processdeadenylation-dependent decapping of nuclear-transcribed mRNA
B0000932cellular_componentP-body
B0003676molecular_functionnucleic acid binding
B0003714molecular_functiontranscription corepressor activity
B0003723molecular_functionRNA binding
B0004518molecular_functionnuclease activity
B0004527molecular_functionexonuclease activity
B0004532molecular_functionRNA exonuclease activity
B0004535molecular_functionpoly(A)-specific ribonuclease activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006417biological_processregulation of translation
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0010629biological_processnegative regulation of gene expression
B0016020cellular_componentmembrane
B0016604cellular_componentnuclear body
B0016607cellular_componentnuclear speck
B0016787molecular_functionhydrolase activity
B0030014cellular_componentCCR4-NOT complex
B0030015cellular_componentCCR4-NOT core complex
B0031047biological_processregulatory ncRNA-mediated gene silencing
B0033962biological_processP-body assembly
B0034584molecular_functionpiRNA binding
B0035279biological_processmiRNA-mediated gene silencing by mRNA destabilization
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0042509biological_processregulation of tyrosine phosphorylation of STAT protein
B0045070biological_processpositive regulation of viral genome replication
B0045892biological_processnegative regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046872molecular_functionmetal ion binding
B0051607biological_processdefense response to virus
B0060213biological_processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
B0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
B0061014biological_processpositive regulation of mRNA catabolic process
B0140297molecular_functionDNA-binding transcription factor binding
B0140991biological_processpiRNA-mediated gene silencing by mRNA destabilization
B1900153biological_processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
BASP40
BGLU42
BASP161
BASP230
BGLU278

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q96LI5
ChainResidueDetails
AGLU240
AGLU276
AHIS361
APRO366
AASP412
AASN414
AASN481
APHE486

237423

PDB entries from 2025-06-11

PDB statisticsPDBj update infoContact PDBjnumon