7AUC
Crystal structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM)
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00690 |
| Number of Residues | 10 |
| Details | DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ArFVIDEAHC |
| Chain | Residue | Details |
| A | ALA790-CYS799 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CDG, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M |
| Chain | Residue | Details |
| A | CYS1036 | |
| A | CYS1055 | |
| A | CYS1063 | |
| A | CYS1066 | |
| A | PHE668 | |
| A | GLY692 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CDG, ECO:0007744|PDB:4CGZ |
| Chain | Residue | Details |
| A | ARG982 | |
| A | ASN1242 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: 3' overhang DNA-binding => ECO:0000269|PubMed:25901030 |
| Chain | Residue | Details |
| A | ARG717 | |
| A | ARG808 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: 3' overhang DNA-binding; via amide nitrogen => ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M |
| Chain | Residue | Details |
| A | ALA920 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: 3' overhang DNA-binding => ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0007744|PDB:4CGZ, ECO:0007744|PDB:4O3M |
| Chain | Residue | Details |
| A | LYS968 | |
| A | THR946 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS863 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER1296 | |
| A | SER1295 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS1207 |
