7AUC

Crystal structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003676	molecular_function	nucleic acid binding
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0006310	biological_process	DNA recombination

Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ArFVIDEAHC

Chain	Residue	Details
A	ALA790-CYS799

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	147
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24816114","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Region: {"description":"3' overhang DNA-binding","evidences":[{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	5
Details	Region: {"description":"3' overhang DNA-binding","evidences":[{"source":"PubMed","id":"24816114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O3M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	17
Details	Region: {"description":"Necessary for ssDNA and DNA Holliday junction binding","evidences":[{"source":"PubMed","id":"20639533","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24816114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CDG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O3M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CDG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CGZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"3' overhang DNA-binding","evidences":[{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Site: {"description":"3' overhang DNA-binding; via amide nitrogen","evidences":[{"source":"PubMed","id":"24816114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O3M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Site: {"description":"3' overhang DNA-binding","evidences":[{"source":"PubMed","id":"24816114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25901030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O3M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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