Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7ASE

43S preinitiation complex from Trypanosoma cruzi with the kDDX60 helicase

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
5	0000049	molecular_function	tRNA binding
5	0000166	molecular_function	nucleotide binding
5	0001731	biological_process	formation of translation preinitiation complex
5	0003743	molecular_function	translation initiation factor activity
5	0003924	molecular_function	GTPase activity
5	0005525	molecular_function	GTP binding
5	0005829	cellular_component	cytosol
5	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
5	0006412	biological_process	translation
5	0006413	biological_process	translational initiation
5	0016787	molecular_function	hydrolase activity
8	0001732	biological_process	formation of cytoplasmic translation initiation complex
8	0002188	biological_process	translation reinitiation
8	0003729	molecular_function	mRNA binding
8	0003743	molecular_function	translation initiation factor activity
8	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
8	0043614	cellular_component	multi-eIF complex
8	0071540	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3e
8	0071541	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3m
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0005737	cellular_component	cytoplasm
A	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
B	0003723	molecular_function	RNA binding
B	0003735	molecular_function	structural constituent of ribosome
B	0005840	cellular_component	ribosome
B	0006412	biological_process	translation
B	0015935	cellular_component	small ribosomal subunit
B	0019843	molecular_function	rRNA binding
B	0022627	cellular_component	cytosolic small ribosomal subunit
B	0042274	biological_process	ribosomal small subunit biogenesis
B	1990904	cellular_component	ribonucleoprotein complex
C	0003723	molecular_function	RNA binding
C	0003743	molecular_function	translation initiation factor activity
C	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0031369	molecular_function	translation initiation factor binding
D	0003735	molecular_function	structural constituent of ribosome
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	1990904	cellular_component	ribonucleoprotein complex
E	0001732	biological_process	formation of cytoplasmic translation initiation complex
E	0002183	biological_process	cytoplasmic translational initiation
E	0003743	molecular_function	translation initiation factor activity
E	0005737	cellular_component	cytoplasm
E	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0016282	cellular_component	eukaryotic 43S preinitiation complex
E	0033290	cellular_component	eukaryotic 48S preinitiation complex
E	0071540	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3e
F	0000028	biological_process	ribosomal small subunit assembly
F	0003735	molecular_function	structural constituent of ribosome
F	0005737	cellular_component	cytoplasm
F	0005840	cellular_component	ribosome
F	0006412	biological_process	translation
F	0015935	cellular_component	small ribosomal subunit
F	0022627	cellular_component	cytosolic small ribosomal subunit
F	1990904	cellular_component	ribonucleoprotein complex
G	0008233	molecular_function	peptidase activity
G	0008237	molecular_function	metallopeptidase activity
I	0003743	molecular_function	translation initiation factor activity
I	0005737	cellular_component	cytoplasm
I	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
I	0006412	biological_process	translation
I	0006413	biological_process	translational initiation
J	0003676	molecular_function	nucleic acid binding
J	0003723	molecular_function	RNA binding
J	0003729	molecular_function	mRNA binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
K	0003743	molecular_function	translation initiation factor activity
K	0005737	cellular_component	cytoplasm
K	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
K	0006413	biological_process	translational initiation
K	0006446	biological_process	regulation of translational initiation
K	0043022	molecular_function	ribosome binding
L	0003735	molecular_function	structural constituent of ribosome
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
L	0015935	cellular_component	small ribosomal subunit
L	1990904	cellular_component	ribonucleoprotein complex
M	0003723	molecular_function	RNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0005634	cellular_component	nucleus
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
M	0015935	cellular_component	small ribosomal subunit
M	0022627	cellular_component	cytosolic small ribosomal subunit
M	1990904	cellular_component	ribonucleoprotein complex
N	0003723	molecular_function	RNA binding
N	0003735	molecular_function	structural constituent of ribosome
N	0005737	cellular_component	cytoplasm
N	0005840	cellular_component	ribosome
N	0022627	cellular_component	cytosolic small ribosomal subunit
N	1990904	cellular_component	ribonucleoprotein complex
O	0000028	biological_process	ribosomal small subunit assembly
O	0003723	molecular_function	RNA binding
O	0003735	molecular_function	structural constituent of ribosome
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
O	0022627	cellular_component	cytosolic small ribosomal subunit
O	1990904	cellular_component	ribonucleoprotein complex
P	0003735	molecular_function	structural constituent of ribosome
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
P	1990904	cellular_component	ribonucleoprotein complex
Q	0002181	biological_process	cytoplasmic translation
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	0008270	molecular_function	zinc ion binding
Q	0022627	cellular_component	cytosolic small ribosomal subunit
Q	1990904	cellular_component	ribonucleoprotein complex
R	0003735	molecular_function	structural constituent of ribosome
R	0005730	cellular_component	nucleolus
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	0022627	cellular_component	cytosolic small ribosomal subunit
R	0070181	molecular_function	small ribosomal subunit rRNA binding
R	1990904	cellular_component	ribonucleoprotein complex
S	0003735	molecular_function	structural constituent of ribosome
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
S	1990904	cellular_component	ribonucleoprotein complex
T	0000028	biological_process	ribosomal small subunit assembly
T	0003723	molecular_function	RNA binding
T	0003735	molecular_function	structural constituent of ribosome
T	0005840	cellular_component	ribosome
T	0006412	biological_process	translation
T	0015935	cellular_component	small ribosomal subunit
T	0022627	cellular_component	cytosolic small ribosomal subunit
T	1990904	cellular_component	ribonucleoprotein complex
U	0000028	biological_process	ribosomal small subunit assembly
U	0003735	molecular_function	structural constituent of ribosome
U	0005840	cellular_component	ribosome
U	0006412	biological_process	translation
U	0022627	cellular_component	cytosolic small ribosomal subunit
U	0030490	biological_process	maturation of SSU-rRNA
U	1990904	cellular_component	ribonucleoprotein complex
V	0003743	molecular_function	translation initiation factor activity
V	0006412	biological_process	translation
V	0006413	biological_process	translational initiation
W	0003735	molecular_function	structural constituent of ribosome
W	0005737	cellular_component	cytoplasm
W	0005840	cellular_component	ribosome
W	0006412	biological_process	translation
W	0022627	cellular_component	cytosolic small ribosomal subunit
W	1990904	cellular_component	ribonucleoprotein complex
X	0003735	molecular_function	structural constituent of ribosome
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	0022627	cellular_component	cytosolic small ribosomal subunit
X	1990904	cellular_component	ribonucleoprotein complex
Y	0000166	molecular_function	nucleotide binding
Y	0001732	biological_process	formation of cytoplasmic translation initiation complex
Y	0003743	molecular_function	translation initiation factor activity
Y	0005092	molecular_function	GDP-dissociation inhibitor activity
Y	0005525	molecular_function	GTP binding
Y	0005829	cellular_component	cytosol
Y	0006412	biological_process	translation
Y	0006413	biological_process	translational initiation
Y	0071074	molecular_function	eukaryotic initiation factor eIF2 binding
Z	0003735	molecular_function	structural constituent of ribosome
Z	0005840	cellular_component	ribosome
Z	0006412	biological_process	translation
Z	1990904	cellular_component	ribonucleoprotein complex
a	0005840	cellular_component	ribosome
a	1990904	cellular_component	ribonucleoprotein complex
b	0003735	molecular_function	structural constituent of ribosome
b	0005840	cellular_component	ribosome
b	0006412	biological_process	translation
b	1990904	cellular_component	ribonucleoprotein complex
c	0003735	molecular_function	structural constituent of ribosome
c	0005829	cellular_component	cytosol
c	0005840	cellular_component	ribosome
c	0006412	biological_process	translation
c	0022627	cellular_component	cytosolic small ribosomal subunit
c	1990904	cellular_component	ribonucleoprotein complex
d	0003723	molecular_function	RNA binding
d	0003735	molecular_function	structural constituent of ribosome
d	0005840	cellular_component	ribosome
d	0006412	biological_process	translation
d	0015935	cellular_component	small ribosomal subunit
d	0022627	cellular_component	cytosolic small ribosomal subunit
d	1990904	cellular_component	ribonucleoprotein complex
f	0000166	molecular_function	nucleotide binding
f	0003676	molecular_function	nucleic acid binding
f	0004386	molecular_function	helicase activity
f	0005524	molecular_function	ATP binding
f	0005737	cellular_component	cytoplasm
f	0016787	molecular_function	hydrolase activity
f	0046872	molecular_function	metal ion binding
g	0003735	molecular_function	structural constituent of ribosome
g	0005840	cellular_component	ribosome
g	0006412	biological_process	translation
g	1990904	cellular_component	ribonucleoprotein complex
h	0003735	molecular_function	structural constituent of ribosome
h	0005840	cellular_component	ribosome
h	0006412	biological_process	translation
h	1990904	cellular_component	ribonucleoprotein complex
i	0003735	molecular_function	structural constituent of ribosome
i	0005840	cellular_component	ribosome
i	0006412	biological_process	translation
i	1990904	cellular_component	ribonucleoprotein complex
j	0003735	molecular_function	structural constituent of ribosome
j	0005840	cellular_component	ribosome
j	0006412	biological_process	translation
j	1990904	cellular_component	ribonucleoprotein complex
l	0003723	molecular_function	RNA binding
l	0003735	molecular_function	structural constituent of ribosome
l	0005840	cellular_component	ribosome
l	0006412	biological_process	translation
l	0019843	molecular_function	rRNA binding
l	0022627	cellular_component	cytosolic small ribosomal subunit
l	1990904	cellular_component	ribonucleoprotein complex
m	0003735	molecular_function	structural constituent of ribosome
m	0005840	cellular_component	ribosome
m	0006412	biological_process	translation
m	0015935	cellular_component	small ribosomal subunit
m	1990904	cellular_component	ribonucleoprotein complex
n	0001731	biological_process	formation of translation preinitiation complex
n	0003729	molecular_function	mRNA binding
n	0003743	molecular_function	translation initiation factor activity
n	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
n	0006412	biological_process	translation
n	0006413	biological_process	translational initiation
n	0031369	molecular_function	translation initiation factor binding
n	0046872	molecular_function	metal ion binding
o	0003723	molecular_function	RNA binding
o	0003735	molecular_function	structural constituent of ribosome
o	0005840	cellular_component	ribosome
o	0006412	biological_process	translation
o	0015935	cellular_component	small ribosomal subunit
o	1990904	cellular_component	ribonucleoprotein complex
p	0005840	cellular_component	ribosome
p	0006417	biological_process	regulation of translation
p	0016301	molecular_function	kinase activity
p	0043022	molecular_function	ribosome binding
p	0045182	molecular_function	translation regulator activity
p	1990904	cellular_component	ribonucleoprotein complex
q	0003735	molecular_function	structural constituent of ribosome
q	0005840	cellular_component	ribosome
q	0006364	biological_process	rRNA processing
q	0006412	biological_process	translation
q	0022627	cellular_component	cytosolic small ribosomal subunit
q	0030686	cellular_component	90S preribosome
q	0032040	cellular_component	small-subunit processome
q	0042274	biological_process	ribosomal small subunit biogenesis
q	1990904	cellular_component	ribonucleoprotein complex
r	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
r	0003723	molecular_function	RNA binding
r	0003735	molecular_function	structural constituent of ribosome
r	0005840	cellular_component	ribosome
r	0006412	biological_process	translation
r	0015935	cellular_component	small ribosomal subunit
r	0022627	cellular_component	cytosolic small ribosomal subunit
r	1990904	cellular_component	ribonucleoprotein complex
s	0003676	molecular_function	nucleic acid binding
s	0003723	molecular_function	RNA binding
s	0003743	molecular_function	translation initiation factor activity
s	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
s	0006412	biological_process	translation
s	0006413	biological_process	translational initiation
s	0033290	cellular_component	eukaryotic 48S preinitiation complex
s	0043022	molecular_function	ribosome binding
t	0003729	molecular_function	mRNA binding
t	0003735	molecular_function	structural constituent of ribosome
t	0005840	cellular_component	ribosome
t	0006412	biological_process	translation
t	0022627	cellular_component	cytosolic small ribosomal subunit
t	1990904	cellular_component	ribonucleoprotein complex
u	0003676	molecular_function	nucleic acid binding
u	0003723	molecular_function	RNA binding
u	0003735	molecular_function	structural constituent of ribosome
u	0005737	cellular_component	cytoplasm
u	0005829	cellular_component	cytosol
u	0005840	cellular_component	ribosome
u	0006412	biological_process	translation
u	0015935	cellular_component	small ribosomal subunit
u	1990904	cellular_component	ribonucleoprotein complex
v	0003735	molecular_function	structural constituent of ribosome
v	0005840	cellular_component	ribosome
v	0006412	biological_process	translation
v	1990904	cellular_component	ribonucleoprotein complex
w	0003723	molecular_function	RNA binding
w	0003743	molecular_function	translation initiation factor activity
w	0006412	biological_process	translation
w	0006413	biological_process	translational initiation
y	0003735	molecular_function	structural constituent of ribosome
y	0005840	cellular_component	ribosome
y	0006412	biological_process	translation
y	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00052
Number of Residues	27
Details	RIBOSOMAL_S7 Ribosomal protein S7 signature. ErLtngLMfkgrgnGKKlqavrLVkhT

Chain	Residue	Details
o	GLU56-THR82

site_id	PS00053
Number of Residues	18
Details	RIBOSOMAL_S8 Ribosomal protein S8 signature. GfvVLTTSlGIMdheeAR

Chain	Residue	Details
b	GLY100-ARG117

site_id	PS00054
Number of Residues	23
Details	RIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarA.GMkIgrieDvTPiPTD

Chain	Residue	Details
v	LEU109-ASP131

site_id	PS00055
Number of Residues	8
Details	RIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAiR

Chain	Residue	Details
m	LYS60-ARG67

site_id	PS00056
Number of Residues	13
Details	RIBOSOMAL_S17 Ribosomal protein S17 signature. GDeViVgQcRPLS

Chain	Residue	Details
X	GLY135-SER147

site_id	PS00323
Number of Residues	25
Details	RIBOSOMAL_S19 Ribosomal protein S19 signature. NGRqfnaveIkgemIGhyLGEFsmT

Chain	Residue	Details
T	ASN105-THR129

site_id	PS00362
Number of Residues	31
Details	RIBOSOMAL_S15 Ribosomal protein S15 signature. MrkHLernTkDrdTkfrLilVesrihrLarY

Chain	Residue	Details
R	MET98-TYR128

site_id	PS00529
Number of Residues	23
Details	RIBOSOMAL_S24E Ribosomal protein S24e signature. FGggKTtGFGlIYDDlaalkriE

Chain	Residue	Details
y	PHE71-GLU93

site_id	PS00585
Number of Residues	33
Details	RIBOSOMAL_S5 Ribosomal protein S5 signature. GQrtrFkAfnIVGDgn.GhIGvGarvgk.EVsl.AI

Chain	Residue	Details
d	GLY100-ILE132

site_id	PS00632
Number of Residues	25
Details	RIBOSOMAL_S4 Ribosomal protein S4 signature. LErRLqtvVFKhglAkSvhhARvLI

Chain	Residue	Details
B	LEU104-ILE128

site_id	PS00646
Number of Residues	14
Details	RIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGvRHayGlrVRGQ

Chain	Residue	Details
u	ARG122-GLN135

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. AVSAswDhSLRLWNL

Chain	Residue	Details
p	ALA82-LEU96
p	ILE124-VAL138
p	ILE169-ILE183
p	CYS211-LEU225

site_id	PS00961
Number of Residues	9
Details	RIBOSOMAL_S28E Ribosomal protein S28e signature. ETEREARrL

Chain	Residue	Details
U	GLU103-LEU111

site_id	PS00963
Number of Residues	25
Details	RIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PrvLLVtDprtDhqaLrEaslvNIP

Chain	Residue	Details
F	PRO122-PRO146

site_id	PS01189
Number of Residues	19
Details	RIBOSOMAL_S12E Ribosomal protein S12e signature. ALRivLqkSrevNGLirGL

Chain	Residue	Details
h	ALA29-LEU47

site_id	PS01193
Number of Residues	20
Details	RIBOSOMAL_S8E Ribosomal protein S8e signature. RkiTGGktkih.RkRmKaELG

Chain	Residue	Details
Z	ARG11-GLY30

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)