Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7AR7

Cryo-EM structure of Arabidopsis thaliana complex-I (open conformation)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
A	0022904	biological_process	respiratory electron transport chain
A	0030964	cellular_component	NADH dehydrogenase complex
A	0031966	cellular_component	mitochondrial membrane
A	0045271	cellular_component	respiratory chain complex I
A	1902600	biological_process	proton transmembrane transport
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0048038	molecular_function	quinone binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0008270	molecular_function	zinc ion binding
C	0009536	cellular_component	plastid
C	0016491	molecular_function	oxidoreductase activity
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	0022904	biological_process	respiratory electron transport chain
C	0045271	cellular_component	respiratory chain complex I
C	0050897	molecular_function	cobalt ion binding
C	1902600	biological_process	proton transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0009536	cellular_component	plastid
D	0016491	molecular_function	oxidoreductase activity
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0022904	biological_process	respiratory electron transport chain
D	0045271	cellular_component	respiratory chain complex I
D	0048038	molecular_function	quinone binding
D	0051287	molecular_function	NAD binding
D	1902600	biological_process	proton transmembrane transport
E	0016491	molecular_function	oxidoreductase activity
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0010181	molecular_function	FMN binding
F	0051287	molecular_function	NAD binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0009507	cellular_component	chloroplast
G	0009536	cellular_component	plastid
G	0009853	biological_process	photorespiration
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0022904	biological_process	respiratory electron transport chain
G	0031966	cellular_component	mitochondrial membrane
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0045271	cellular_component	respiratory chain complex I
G	0046872	molecular_function	metal ion binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	1902600	biological_process	proton transmembrane transport
H	0003674	molecular_function	molecular_function
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005575	cellular_component	cellular_component
H	0005743	cellular_component	mitochondrial inner membrane
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0008150	biological_process	biological_process
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0022904	biological_process	respiratory electron transport chain
H	0045271	cellular_component	respiratory chain complex I
H	1902600	biological_process	proton transmembrane transport
I	0016020	cellular_component	membrane
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
J	0005739	cellular_component	mitochondrion
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0022904	biological_process	respiratory electron transport chain
J	0031966	cellular_component	mitochondrial membrane
J	0045271	cellular_component	respiratory chain complex I
J	1902600	biological_process	proton transmembrane transport
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0042773	biological_process	ATP synthesis coupled electron transport
L	0005743	cellular_component	mitochondrial inner membrane
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0009536	cellular_component	plastid
L	0015990	biological_process	electron transport coupled proton transport
L	0022904	biological_process	respiratory electron transport chain
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0045271	cellular_component	respiratory chain complex I
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0009536	cellular_component	plastid
M	0015990	biological_process	electron transport coupled proton transport
M	0022904	biological_process	respiratory electron transport chain
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0045271	cellular_component	respiratory chain complex I
M	0048039	molecular_function	ubiquinone binding
N	0003954	molecular_function	NADH dehydrogenase activity
N	0005743	cellular_component	mitochondrial inner membrane
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0009507	cellular_component	chloroplast
N	0009536	cellular_component	plastid
N	0022904	biological_process	respiratory electron transport chain
N	0042773	biological_process	ATP synthesis coupled electron transport
N	0045271	cellular_component	respiratory chain complex I
N	0045333	biological_process	cellular respiration
N	1902600	biological_process	proton transmembrane transport
Q	0022900	biological_process	electron transport chain
S	0003674	molecular_function	molecular_function
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0008150	biological_process	biological_process
S	0009507	cellular_component	chloroplast
S	0009536	cellular_component	plastid
S	0022904	biological_process	respiratory electron transport chain
S	0045271	cellular_component	respiratory chain complex I
T	0006633	biological_process	fatty acid biosynthetic process
U	0006633	biological_process	fatty acid biosynthetic process
V	0022904	biological_process	respiratory electron transport chain
W	0003674	molecular_function	molecular_function
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005829	cellular_component	cytosol
W	0022904	biological_process	respiratory electron transport chain
W	0045271	cellular_component	respiratory chain complex I
X	0003674	molecular_function	molecular_function
X	0005739	cellular_component	mitochondrion
X	0005758	cellular_component	mitochondrial intermembrane space
X	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
X	0009507	cellular_component	chloroplast
X	0009536	cellular_component	plastid
X	0022904	biological_process	respiratory electron transport chain
X	0045271	cellular_component	respiratory chain complex I
d	0000325	cellular_component	plant-type vacuole
d	0003674	molecular_function	molecular_function
d	0005739	cellular_component	mitochondrion
d	0005829	cellular_component	cytosol
d	0008150	biological_process	biological_process
d	0009507	cellular_component	chloroplast
d	0045271	cellular_component	respiratory chain complex I
f	0003674	molecular_function	molecular_function
f	0005739	cellular_component	mitochondrion
f	0005829	cellular_component	cytosol
f	0009853	biological_process	photorespiration
f	0031966	cellular_component	mitochondrial membrane
f	0045271	cellular_component	respiratory chain complex I
j	0005743	cellular_component	mitochondrial inner membrane
j	0045271	cellular_component	respiratory chain complex I
k	0005739	cellular_component	mitochondrion
k	0022900	biological_process	electron transport chain
m	0003674	molecular_function	molecular_function
m	0005739	cellular_component	mitochondrion
m	0009853	biological_process	photorespiration
m	0031966	cellular_component	mitochondrial membrane
m	0045271	cellular_component	respiratory chain complex I
n	0000325	cellular_component	plant-type vacuole
n	0003674	molecular_function	molecular_function
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0005886	cellular_component	plasma membrane
n	0005975	biological_process	carbohydrate metabolic process
n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
n	0009853	biological_process	photorespiration
n	0022904	biological_process	respiratory electron transport chain
n	0031966	cellular_component	mitochondrial membrane
n	0045271	cellular_component	respiratory chain complex I
o	0005739	cellular_component	mitochondrion
q	0016020	cellular_component	membrane
q	0045271	cellular_component	respiratory chain complex I
y	0004089	molecular_function	carbonate dehydratase activity
y	0005515	molecular_function	protein binding
y	0005634	cellular_component	nucleus
y	0005737	cellular_component	cytoplasm
y	0005739	cellular_component	mitochondrion
y	0009853	biological_process	photorespiration
y	0009901	biological_process	anther dehiscence
y	0016829	molecular_function	lyase activity
y	0031966	cellular_component	mitochondrial membrane
y	0042802	molecular_function	identical protein binding
y	0045271	cellular_component	respiratory chain complex I
y	0046872	molecular_function	metal ion binding
y	0070207	biological_process	protein homotrimerization
y	2000377	biological_process	regulation of reactive oxygen species metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDSVEVVMAL

Chain	Residue	Details
U	ASP78-LEU93
T	ASP74-ILE89

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
I	CYS123-PRO134
I	CYS162-PRO173

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
D	LEU47-LYS58

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREvwDMFgvsfinHpdlRrIL

Chain	Residue	Details
C	GLU112-LEU133

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYhsrlsiaGnCRmC

Chain	Residue	Details
G	PRO103-CYS120

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
G	CYS170-GLN182

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCVrF

Chain	Residue	Details
G	ARG217-PHE227

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALLES

Chain	Residue	Details
F	GLY223-SER238

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
F	GLU400-GLY411

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpLaDGLKLIlKE

Chain	Residue	Details
H	GLY47-GLU62

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLPEAEaeLVa.G

Chain	Residue	Details
H	PRO202-GLY215

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DglFSvgemeCMGcCvnAP

Chain	Residue	Details
E	ASP161-PRO179

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
B	GLY174-PRO190

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1179
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	87
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	78
Details	Domain: {"description":"2Fe-2S ferredoxin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00465","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	39
Details	Domain: {"description":"4Fe-4S His(Cys)3-ligated-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	56
Details	Domain: {"description":"4Fe-4S Mo/W bis-MGD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01004","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 1"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	150
Details	Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	41
Details	Domain: {"description":"CHCH 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	30
Details	Motif: {"description":"Cx9C motif 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	30
Details	Motif: {"description":"Cx9C motif 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	10
Details	Motif: {"description":"Cx9C motif 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	11
Details	Motif: {"description":"Cx10C motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	83
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)