Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7AQO

yeast THO-Sub2 complex dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000347	cellular_component	THO complex
A	0000445	cellular_component	THO complex part of transcription export complex
A	0000446	cellular_component	nucleoplasmic THO complex
A	0000781	cellular_component	chromosome, telomeric region
A	0003676	molecular_function	nucleic acid binding
A	0003729	molecular_function	mRNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0006283	biological_process	transcription-coupled nucleotide-excision repair
A	0006310	biological_process	DNA recombination
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0006397	biological_process	mRNA processing
A	0006406	biological_process	mRNA export from nucleus
A	0031124	biological_process	mRNA 3'-end processing
A	0034063	biological_process	stress granule assembly
A	0045943	biological_process	positive regulation of transcription by RNA polymerase I
A	0097185	biological_process	cellular response to azide
A	2001209	biological_process	positive regulation of transcription elongation by RNA polymerase I
B	0000445	cellular_component	THO complex part of transcription export complex
B	0000446	cellular_component	nucleoplasmic THO complex
B	0000781	cellular_component	chromosome, telomeric region
B	0003676	molecular_function	nucleic acid binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0006283	biological_process	transcription-coupled nucleotide-excision repair
B	0006310	biological_process	DNA recombination
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0006406	biological_process	mRNA export from nucleus
B	0016593	cellular_component	Cdc73/Paf1 complex
B	0031124	biological_process	mRNA 3'-end processing
B	0045943	biological_process	positive regulation of transcription by RNA polymerase I
B	0060090	molecular_function	molecular adaptor activity
B	2001209	biological_process	positive regulation of transcription elongation by RNA polymerase I
C	0000445	cellular_component	THO complex part of transcription export complex
C	0000446	cellular_component	nucleoplasmic THO complex
C	0003676	molecular_function	nucleic acid binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006310	biological_process	DNA recombination
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0006406	biological_process	mRNA export from nucleus
C	0034063	biological_process	stress granule assembly
C	0097185	biological_process	cellular response to azide
D	0000445	cellular_component	THO complex part of transcription export complex
D	0000446	cellular_component	nucleoplasmic THO complex
D	0000781	cellular_component	chromosome, telomeric region
D	0003676	molecular_function	nucleic acid binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006310	biological_process	DNA recombination
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0006397	biological_process	mRNA processing
D	0006406	biological_process	mRNA export from nucleus
D	0060090	molecular_function	molecular adaptor activity
E	0000346	cellular_component	transcription export complex
E	0000445	cellular_component	THO complex part of transcription export complex
E	0003729	molecular_function	mRNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0006406	biological_process	mRNA export from nucleus
F	0003676	molecular_function	nucleic acid binding
F	0003724	molecular_function	RNA helicase activity
F	0005524	molecular_function	ATP binding
G	0000347	cellular_component	THO complex
G	0000445	cellular_component	THO complex part of transcription export complex
G	0000446	cellular_component	nucleoplasmic THO complex
G	0000781	cellular_component	chromosome, telomeric region
G	0003676	molecular_function	nucleic acid binding
G	0003729	molecular_function	mRNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0006283	biological_process	transcription-coupled nucleotide-excision repair
G	0006310	biological_process	DNA recombination
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0006397	biological_process	mRNA processing
G	0006406	biological_process	mRNA export from nucleus
G	0031124	biological_process	mRNA 3'-end processing
G	0034063	biological_process	stress granule assembly
G	0045943	biological_process	positive regulation of transcription by RNA polymerase I
G	0097185	biological_process	cellular response to azide
G	2001209	biological_process	positive regulation of transcription elongation by RNA polymerase I
H	0000445	cellular_component	THO complex part of transcription export complex
H	0000446	cellular_component	nucleoplasmic THO complex
H	0000781	cellular_component	chromosome, telomeric region
H	0003676	molecular_function	nucleic acid binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0006283	biological_process	transcription-coupled nucleotide-excision repair
H	0006310	biological_process	DNA recombination
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0006406	biological_process	mRNA export from nucleus
H	0016593	cellular_component	Cdc73/Paf1 complex
H	0031124	biological_process	mRNA 3'-end processing
H	0045943	biological_process	positive regulation of transcription by RNA polymerase I
H	0060090	molecular_function	molecular adaptor activity
H	2001209	biological_process	positive regulation of transcription elongation by RNA polymerase I
I	0000445	cellular_component	THO complex part of transcription export complex
I	0000446	cellular_component	nucleoplasmic THO complex
I	0000781	cellular_component	chromosome, telomeric region
I	0003676	molecular_function	nucleic acid binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0006310	biological_process	DNA recombination
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0006397	biological_process	mRNA processing
I	0006406	biological_process	mRNA export from nucleus
I	0060090	molecular_function	molecular adaptor activity
J	0000445	cellular_component	THO complex part of transcription export complex
J	0000446	cellular_component	nucleoplasmic THO complex
J	0003676	molecular_function	nucleic acid binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0006310	biological_process	DNA recombination
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0006406	biological_process	mRNA export from nucleus
J	0034063	biological_process	stress granule assembly
J	0097185	biological_process	cellular response to azide
K	0000346	cellular_component	transcription export complex
K	0000445	cellular_component	THO complex part of transcription export complex
K	0003729	molecular_function	mRNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0006406	biological_process	mRNA export from nucleus
L	0003676	molecular_function	nucleic acid binding
L	0003724	molecular_function	RNA helicase activity
L	0005524	molecular_function	ATP binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	78
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	78
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	78
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	78
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	78
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	322
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	56
Details	Motif: {"description":"Q motif"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	6
Details	Motif: {"description":"DECD box"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	14
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)