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7AQK

Model of the actin filament Arp2/3 complex branch junction in cells

Functional Information from GO Data
ChainGOidnamespacecontents
a0003779molecular_functionactin binding
a0005200molecular_functionstructural constituent of cytoskeleton
a0005515molecular_functionprotein binding
a0005524molecular_functionATP binding
a0005634cellular_componentnucleus
a0005737cellular_componentcytoplasm
a0005856cellular_componentcytoskeleton
a0005885cellular_componentArp2/3 protein complex
a0005903cellular_componentbrush border
a0005911cellular_componentcell-cell junction
a0007163biological_processestablishment or maintenance of cell polarity
a0008356biological_processasymmetric cell division
a0010592biological_processpositive regulation of lamellipodium assembly
a0016344biological_processmeiotic chromosome movement towards spindle pole
a0030027cellular_componentlamellipodium
a0030030biological_processcell projection organization
a0033206biological_processmeiotic cytokinesis
a0034314biological_processArp2/3 complex-mediated actin nucleation
a0035861cellular_componentsite of double-strand break
a0042995cellular_componentcell projection
a0045944biological_processpositive regulation of transcription by RNA polymerase II
a0051015molecular_functionactin filament binding
a0051321biological_processmeiotic cell cycle
a0051653biological_processspindle localization
a0060271biological_processcilium assembly
a0071346biological_processcellular response to type II interferon
b0003779molecular_functionactin binding
b0005200molecular_functionstructural constituent of cytoskeleton
b0005515molecular_functionprotein binding
b0005524molecular_functionATP binding
b0005634cellular_componentnucleus
b0005737cellular_componentcytoplasm
b0005829cellular_componentcytosol
b0005856cellular_componentcytoskeleton
b0005885cellular_componentArp2/3 protein complex
b0005938cellular_componentcell cortex
b0007163biological_processestablishment or maintenance of cell polarity
b0008356biological_processasymmetric cell division
b0010592biological_processpositive regulation of lamellipodium assembly
b0016344biological_processmeiotic chromosome movement towards spindle pole
b0016482biological_processcytosolic transport
b0030036biological_processactin cytoskeleton organization
b0030478cellular_componentactin cap
b0033206biological_processmeiotic cytokinesis
b0034314biological_processArp2/3 complex-mediated actin nucleation
b0035861cellular_componentsite of double-strand break
b0042995cellular_componentcell projection
b0045944biological_processpositive regulation of transcription by RNA polymerase II
b0051015molecular_functionactin filament binding
b0051321biological_processmeiotic cell cycle
b0051653biological_processspindle localization
b0060271biological_processcilium assembly
b0071346biological_processcellular response to type II interferon
b1905168biological_processpositive regulation of double-strand break repair via homologous recombination
b2001032biological_processregulation of double-strand break repair via nonhomologous end joining
c0003779molecular_functionactin binding
c0005634cellular_componentnucleus
c0005737cellular_componentcytoplasm
c0005856cellular_componentcytoskeleton
c0005885cellular_componentArp2/3 protein complex
c0015629cellular_componentactin cytoskeleton
c0034314biological_processArp2/3 complex-mediated actin nucleation
d0003779molecular_functionactin binding
d0005200molecular_functionstructural constituent of cytoskeleton
d0005515molecular_functionprotein binding
d0005634cellular_componentnucleus
d0005654cellular_componentnucleoplasm
d0005737cellular_componentcytoplasm
d0005768cellular_componentendosome
d0005856cellular_componentcytoskeleton
d0005885cellular_componentArp2/3 protein complex
d0005886cellular_componentplasma membrane
d0005925cellular_componentfocal adhesion
d0010592biological_processpositive regulation of lamellipodium assembly
d0015629cellular_componentactin cytoskeleton
d0030027cellular_componentlamellipodium
d0030041biological_processactin filament polymerization
d0030672cellular_componentsynaptic vesicle membrane
d0030838biological_processpositive regulation of actin filament polymerization
d0031252cellular_componentcell leading edge
d0034314biological_processArp2/3 complex-mediated actin nucleation
d0035861cellular_componentsite of double-strand break
d0036195cellular_componentmuscle cell projection membrane
d0042995cellular_componentcell projection
d0043005cellular_componentneuron projection
d0045202cellular_componentsynapse
d0051015molecular_functionactin filament binding
d0098793cellular_componentpresynapse
d0098794cellular_componentpostsynapse
d0098978cellular_componentglutamatergic synapse
d1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
e0003779molecular_functionactin binding
e0005200molecular_functionstructural constituent of cytoskeleton
e0005515molecular_functionprotein binding
e0005634cellular_componentnucleus
e0005737cellular_componentcytoplasm
e0005856cellular_componentcytoskeleton
e0005885cellular_componentArp2/3 protein complex
e0030027cellular_componentlamellipodium
e0030833biological_processregulation of actin filament polymerization
e0034314biological_processArp2/3 complex-mediated actin nucleation
e0035861cellular_componentsite of double-strand break
e0042995cellular_componentcell projection
e0051015molecular_functionactin filament binding
e1900242biological_processregulation of synaptic vesicle endocytosis
f0003779molecular_functionactin binding
f0005200molecular_functionstructural constituent of cytoskeleton
f0005634cellular_componentnucleus
f0005737cellular_componentcytoplasm
f0005856cellular_componentcytoskeleton
f0005885cellular_componentArp2/3 protein complex
f0015629cellular_componentactin cytoskeleton
f0019899molecular_functionenzyme binding
f0030041biological_processactin filament polymerization
f0030674molecular_functionprotein-macromolecule adaptor activity
f0034314biological_processArp2/3 complex-mediated actin nucleation
f0035861cellular_componentsite of double-strand break
f0042995cellular_componentcell projection
f0051015molecular_functionactin filament binding
g0003779molecular_functionactin binding
g0005200molecular_functionstructural constituent of cytoskeleton
g0005634cellular_componentnucleus
g0005737cellular_componentcytoplasm
g0005856cellular_componentcytoskeleton
g0005885cellular_componentArp2/3 protein complex
g0015629cellular_componentactin cytoskeleton
g0016477biological_processcell migration
g0030027cellular_componentlamellipodium
g0030833biological_processregulation of actin filament polymerization
g0034314biological_processArp2/3 complex-mediated actin nucleation
g0035861cellular_componentsite of double-strand break
g0042995cellular_componentcell projection
g0051015molecular_functionactin filament binding
h0001725cellular_componentstress fiber
h0005515molecular_functionprotein binding
h0005524molecular_functionATP binding
h0005737cellular_componentcytoplasm
h0005856cellular_componentcytoskeleton
h0005865cellular_componentstriated muscle thin filament
h0005884cellular_componentactin filament
h0009612biological_processresponse to mechanical stimulus
h0010628biological_processpositive regulation of gene expression
h0015629cellular_componentactin cytoskeleton
h0016787molecular_functionhydrolase activity
h0030017cellular_componentsarcomere
h0030027cellular_componentlamellipodium
h0030175cellular_componentfilopodium
h0030240biological_processskeletal muscle thin filament assembly
h0032991cellular_componentprotein-containing complex
h0035865biological_processcellular response to potassium ion
h0043503biological_processskeletal muscle fiber adaptation
h0044297cellular_componentcell body
h0048545biological_processresponse to steroid hormone
h0048741biological_processskeletal muscle fiber development
h0090131biological_processmesenchyme migration
i0001725cellular_componentstress fiber
i0005515molecular_functionprotein binding
i0005524molecular_functionATP binding
i0005737cellular_componentcytoplasm
i0005856cellular_componentcytoskeleton
i0005865cellular_componentstriated muscle thin filament
i0005884cellular_componentactin filament
i0009612biological_processresponse to mechanical stimulus
i0010628biological_processpositive regulation of gene expression
i0015629cellular_componentactin cytoskeleton
i0016787molecular_functionhydrolase activity
i0030017cellular_componentsarcomere
i0030027cellular_componentlamellipodium
i0030175cellular_componentfilopodium
i0030240biological_processskeletal muscle thin filament assembly
i0032991cellular_componentprotein-containing complex
i0035865biological_processcellular response to potassium ion
i0043503biological_processskeletal muscle fiber adaptation
i0044297cellular_componentcell body
i0048545biological_processresponse to steroid hormone
i0048741biological_processskeletal muscle fiber development
i0090131biological_processmesenchyme migration
j0001725cellular_componentstress fiber
j0005515molecular_functionprotein binding
j0005524molecular_functionATP binding
j0005737cellular_componentcytoplasm
j0005856cellular_componentcytoskeleton
j0005865cellular_componentstriated muscle thin filament
j0005884cellular_componentactin filament
j0009612biological_processresponse to mechanical stimulus
j0010628biological_processpositive regulation of gene expression
j0015629cellular_componentactin cytoskeleton
j0016787molecular_functionhydrolase activity
j0030017cellular_componentsarcomere
j0030027cellular_componentlamellipodium
j0030175cellular_componentfilopodium
j0030240biological_processskeletal muscle thin filament assembly
j0032991cellular_componentprotein-containing complex
j0035865biological_processcellular response to potassium ion
j0043503biological_processskeletal muscle fiber adaptation
j0044297cellular_componentcell body
j0048545biological_processresponse to steroid hormone
j0048741biological_processskeletal muscle fiber development
j0090131biological_processmesenchyme migration
k0001725cellular_componentstress fiber
k0005515molecular_functionprotein binding
k0005524molecular_functionATP binding
k0005737cellular_componentcytoplasm
k0005856cellular_componentcytoskeleton
k0005865cellular_componentstriated muscle thin filament
k0005884cellular_componentactin filament
k0009612biological_processresponse to mechanical stimulus
k0010628biological_processpositive regulation of gene expression
k0015629cellular_componentactin cytoskeleton
k0016787molecular_functionhydrolase activity
k0030017cellular_componentsarcomere
k0030027cellular_componentlamellipodium
k0030175cellular_componentfilopodium
k0030240biological_processskeletal muscle thin filament assembly
k0032991cellular_componentprotein-containing complex
k0035865biological_processcellular response to potassium ion
k0043503biological_processskeletal muscle fiber adaptation
k0044297cellular_componentcell body
k0048545biological_processresponse to steroid hormone
k0048741biological_processskeletal muscle fiber development
k0090131biological_processmesenchyme migration
l0001725cellular_componentstress fiber
l0005515molecular_functionprotein binding
l0005524molecular_functionATP binding
l0005737cellular_componentcytoplasm
l0005856cellular_componentcytoskeleton
l0005865cellular_componentstriated muscle thin filament
l0005884cellular_componentactin filament
l0009612biological_processresponse to mechanical stimulus
l0010628biological_processpositive regulation of gene expression
l0015629cellular_componentactin cytoskeleton
l0016787molecular_functionhydrolase activity
l0030017cellular_componentsarcomere
l0030027cellular_componentlamellipodium
l0030175cellular_componentfilopodium
l0030240biological_processskeletal muscle thin filament assembly
l0032991cellular_componentprotein-containing complex
l0035865biological_processcellular response to potassium ion
l0043503biological_processskeletal muscle fiber adaptation
l0044297cellular_componentcell body
l0048545biological_processresponse to steroid hormone
l0048741biological_processskeletal muscle fiber development
l0090131biological_processmesenchyme migration
m0001725cellular_componentstress fiber
m0005515molecular_functionprotein binding
m0005524molecular_functionATP binding
m0005737cellular_componentcytoplasm
m0005856cellular_componentcytoskeleton
m0005865cellular_componentstriated muscle thin filament
m0005884cellular_componentactin filament
m0009612biological_processresponse to mechanical stimulus
m0010628biological_processpositive regulation of gene expression
m0015629cellular_componentactin cytoskeleton
m0016787molecular_functionhydrolase activity
m0030017cellular_componentsarcomere
m0030027cellular_componentlamellipodium
m0030175cellular_componentfilopodium
m0030240biological_processskeletal muscle thin filament assembly
m0032991cellular_componentprotein-containing complex
m0035865biological_processcellular response to potassium ion
m0043503biological_processskeletal muscle fiber adaptation
m0044297cellular_componentcell body
m0048545biological_processresponse to steroid hormone
m0048741biological_processskeletal muscle fiber development
m0090131biological_processmesenchyme migration
n0001725cellular_componentstress fiber
n0005515molecular_functionprotein binding
n0005524molecular_functionATP binding
n0005737cellular_componentcytoplasm
n0005856cellular_componentcytoskeleton
n0005865cellular_componentstriated muscle thin filament
n0005884cellular_componentactin filament
n0009612biological_processresponse to mechanical stimulus
n0010628biological_processpositive regulation of gene expression
n0015629cellular_componentactin cytoskeleton
n0016787molecular_functionhydrolase activity
n0030017cellular_componentsarcomere
n0030027cellular_componentlamellipodium
n0030175cellular_componentfilopodium
n0030240biological_processskeletal muscle thin filament assembly
n0032991cellular_componentprotein-containing complex
n0035865biological_processcellular response to potassium ion
n0043503biological_processskeletal muscle fiber adaptation
n0044297cellular_componentcell body
n0048545biological_processresponse to steroid hormone
n0048741biological_processskeletal muscle fiber development
n0090131biological_processmesenchyme migration
o0001725cellular_componentstress fiber
o0005515molecular_functionprotein binding
o0005524molecular_functionATP binding
o0005737cellular_componentcytoplasm
o0005856cellular_componentcytoskeleton
o0005865cellular_componentstriated muscle thin filament
o0005884cellular_componentactin filament
o0009612biological_processresponse to mechanical stimulus
o0010628biological_processpositive regulation of gene expression
o0015629cellular_componentactin cytoskeleton
o0016787molecular_functionhydrolase activity
o0030017cellular_componentsarcomere
o0030027cellular_componentlamellipodium
o0030175cellular_componentfilopodium
o0030240biological_processskeletal muscle thin filament assembly
o0032991cellular_componentprotein-containing complex
o0035865biological_processcellular response to potassium ion
o0043503biological_processskeletal muscle fiber adaptation
o0044297cellular_componentcell body
o0048545biological_processresponse to steroid hormone
o0048741biological_processskeletal muscle fiber development
o0090131biological_processmesenchyme migration
p0001725cellular_componentstress fiber
p0005515molecular_functionprotein binding
p0005524molecular_functionATP binding
p0005737cellular_componentcytoplasm
p0005856cellular_componentcytoskeleton
p0005865cellular_componentstriated muscle thin filament
p0005884cellular_componentactin filament
p0009612biological_processresponse to mechanical stimulus
p0010628biological_processpositive regulation of gene expression
p0015629cellular_componentactin cytoskeleton
p0016787molecular_functionhydrolase activity
p0030017cellular_componentsarcomere
p0030027cellular_componentlamellipodium
p0030175cellular_componentfilopodium
p0030240biological_processskeletal muscle thin filament assembly
p0032991cellular_componentprotein-containing complex
p0035865biological_processcellular response to potassium ion
p0043503biological_processskeletal muscle fiber adaptation
p0044297cellular_componentcell body
p0048545biological_processresponse to steroid hormone
p0048741biological_processskeletal muscle fiber development
p0090131biological_processmesenchyme migration
q0001725cellular_componentstress fiber
q0005515molecular_functionprotein binding
q0005524molecular_functionATP binding
q0005737cellular_componentcytoplasm
q0005856cellular_componentcytoskeleton
q0005865cellular_componentstriated muscle thin filament
q0005884cellular_componentactin filament
q0009612biological_processresponse to mechanical stimulus
q0010628biological_processpositive regulation of gene expression
q0015629cellular_componentactin cytoskeleton
q0016787molecular_functionhydrolase activity
q0030017cellular_componentsarcomere
q0030027cellular_componentlamellipodium
q0030175cellular_componentfilopodium
q0030240biological_processskeletal muscle thin filament assembly
q0032991cellular_componentprotein-containing complex
q0035865biological_processcellular response to potassium ion
q0043503biological_processskeletal muscle fiber adaptation
q0044297cellular_componentcell body
q0048545biological_processresponse to steroid hormone
q0048741biological_processskeletal muscle fiber development
q0090131biological_processmesenchyme migration
r0001725cellular_componentstress fiber
r0005515molecular_functionprotein binding
r0005524molecular_functionATP binding
r0005737cellular_componentcytoplasm
r0005856cellular_componentcytoskeleton
r0005865cellular_componentstriated muscle thin filament
r0005884cellular_componentactin filament
r0009612biological_processresponse to mechanical stimulus
r0010628biological_processpositive regulation of gene expression
r0015629cellular_componentactin cytoskeleton
r0016787molecular_functionhydrolase activity
r0030017cellular_componentsarcomere
r0030027cellular_componentlamellipodium
r0030175cellular_componentfilopodium
r0030240biological_processskeletal muscle thin filament assembly
r0032991cellular_componentprotein-containing complex
r0035865biological_processcellular response to potassium ion
r0043503biological_processskeletal muscle fiber adaptation
r0044297cellular_componentcell body
r0048545biological_processresponse to steroid hormone
r0048741biological_processskeletal muscle fiber development
r0090131biological_processmesenchyme migration
Functional Information from PROSITE/UniProt
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
hTYR53-GLY63

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WITKqEYDE
ChainResidueDetails
hTRP356-GLU364

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEPpLNTpeNR
ChainResidueDetails
aLEU111-ARG123
hLEU104-ARG116
bLEU108-ARG120

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues11
DetailsMOD_RES: N-acetylcysteine; in intermediate form => ECO:0000269|PubMed:36173861
ChainResidueDetails
hCYS0
qCYS0
rCYS0
iCYS0
jCYS0
kCYS0
lCYS0
mCYS0
nCYS0
oCYS0
pCYS0

site_idSWS_FT_FI2
Number of Residues22
DetailsMOD_RES: Methionine (R)-sulfoxide => ECO:0000269|PubMed:23911929
ChainResidueDetails
hMET44
lMET47
mMET44
mMET47
nMET44
nMET47
oMET44
oMET47
pMET44
pMET47
qMET44
hMET47
qMET47
rMET44
rMET47
iMET44
iMET47
jMET44
jMET47
kMET44
kMET47
lMET44

site_idSWS_FT_FI3
Number of Residues11
DetailsMOD_RES: N6-malonyllysine => ECO:0000250
ChainResidueDetails
hLYS61
qLYS61
rLYS61
iLYS61
jLYS61
kLYS61
lLYS61
mLYS61
nLYS61
oLYS61
pLYS61

site_idSWS_FT_FI4
Number of Residues11
DetailsMOD_RES: Tele-methylhistidine => ECO:0000250|UniProtKB:P68138
ChainResidueDetails
hHIS73
qHIS73
rHIS73
iHIS73
jHIS73
kHIS73
lHIS73
mHIS73
nHIS73
oHIS73
pHIS73

site_idSWS_FT_FI5
Number of Residues11
DetailsMOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68133
ChainResidueDetails
hLYS84
qLYS84
rLYS84
iLYS84
jLYS84
kLYS84
lLYS84
mLYS84
nLYS84
oLYS84
pLYS84

225158

PDB entries from 2024-09-18

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