7AQK

Model of the actin filament Arp2/3 complex branch junction in cells

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000139	cellular_component	Golgi membrane
a	0000166	molecular_function	nucleotide binding
a	0001726	cellular_component	ruffle
a	0002102	cellular_component	podosome
a	0003779	molecular_function	actin binding
a	0005200	molecular_function	structural constituent of cytoskeleton
a	0005515	molecular_function	protein binding
a	0005524	molecular_function	ATP binding
a	0005634	cellular_component	nucleus
a	0005737	cellular_component	cytoplasm
a	0005856	cellular_component	cytoskeleton
a	0005884	cellular_component	actin filament
a	0005885	cellular_component	Arp2/3 protein complex
a	0005903	cellular_component	brush border
a	0005911	cellular_component	cell-cell junction
a	0007163	biological_process	establishment or maintenance of cell polarity
a	0007283	biological_process	spermatogenesis
a	0008356	biological_process	asymmetric cell division
a	0010592	biological_process	positive regulation of lamellipodium assembly
a	0010763	biological_process	positive regulation of fibroblast migration
a	0016344	biological_process	meiotic chromosome movement towards spindle pole
a	0030027	cellular_component	lamellipodium
a	0030030	biological_process	cell projection organization
a	0030056	cellular_component	hemidesmosome
a	0030517	biological_process	negative regulation of axon extension
a	0030838	biological_process	positive regulation of actin filament polymerization
a	0031252	cellular_component	cell leading edge
a	0032355	biological_process	response to estradiol
a	0032956	biological_process	regulation of actin cytoskeleton organization
a	0033206	biological_process	meiotic cytokinesis
a	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
a	0035861	cellular_component	site of double-strand break
a	0035984	biological_process	cellular response to trichostatin A
a	0042995	cellular_component	cell projection
a	0043519	biological_process	regulation of myosin II filament organization
a	0045666	biological_process	positive regulation of neuron differentiation
a	0045944	biological_process	positive regulation of transcription by RNA polymerase II
a	0048471	cellular_component	perinuclear region of cytoplasm
a	0048708	biological_process	astrocyte differentiation
a	0048711	biological_process	positive regulation of astrocyte differentiation
a	0050775	biological_process	positive regulation of dendrite morphogenesis
a	0051015	molecular_function	actin filament binding
a	0051117	molecular_function	ATPase binding
a	0051321	biological_process	meiotic cell cycle
a	0051491	biological_process	positive regulation of filopodium assembly
a	0051653	biological_process	spindle localization
a	0051965	biological_process	positive regulation of synapse assembly
a	0060076	cellular_component	excitatory synapse
a	0060271	biological_process	cilium assembly
a	0061003	biological_process	positive regulation of dendritic spine morphogenesis
a	0061825	cellular_component	podosome core
a	0061828	cellular_component	apical tubulobulbar complex
a	0061830	cellular_component	concave side of sperm head
a	0061831	cellular_component	apical ectoplasmic specialization
a	0061832	cellular_component	basal ectoplasmic specialization
a	0061843	biological_process	Sertoli cell barrier remodeling
a	0061851	cellular_component	leading edge of lamellipodium
a	0071346	biological_process	cellular response to type II interferon
a	0071347	biological_process	cellular response to interleukin-1
a	0071356	biological_process	cellular response to tumor necrosis factor
a	0071364	biological_process	cellular response to epidermal growth factor stimulus
a	0071503	biological_process	response to heparin
a	0071560	biological_process	cellular response to transforming growth factor beta stimulus
a	0090314	biological_process	positive regulation of protein targeting to membrane
a	0098794	cellular_component	postsynapse
a	0098974	biological_process	postsynaptic actin cytoskeleton organization
a	0098978	cellular_component	glutamatergic synapse
a	0099173	biological_process	postsynapse organization
a	1903078	biological_process	positive regulation of protein localization to plasma membrane
a	1904171	biological_process	negative regulation of bleb assembly
a	1905835	biological_process	cellular response to pyrimidine ribonucleotide
a	1905837	biological_process	cellular response to triterpenoid
b	0000166	molecular_function	nucleotide binding
b	0003779	molecular_function	actin binding
b	0005200	molecular_function	structural constituent of cytoskeleton
b	0005515	molecular_function	protein binding
b	0005524	molecular_function	ATP binding
b	0005634	cellular_component	nucleus
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005856	cellular_component	cytoskeleton
b	0005885	cellular_component	Arp2/3 protein complex
b	0005938	cellular_component	cell cortex
b	0007163	biological_process	establishment or maintenance of cell polarity
b	0008356	biological_process	asymmetric cell division
b	0010592	biological_process	positive regulation of lamellipodium assembly
b	0016344	biological_process	meiotic chromosome movement towards spindle pole
b	0016482	biological_process	cytosolic transport
b	0030036	biological_process	actin cytoskeleton organization
b	0030478	cellular_component	actin cap
b	0033206	biological_process	meiotic cytokinesis
b	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
b	0035861	cellular_component	site of double-strand break
b	0042995	cellular_component	cell projection
b	0045944	biological_process	positive regulation of transcription by RNA polymerase II
b	0051015	molecular_function	actin filament binding
b	0051321	biological_process	meiotic cell cycle
b	0051653	biological_process	spindle localization
b	0060271	biological_process	cilium assembly
b	0071346	biological_process	cellular response to type II interferon
b	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
b	2001032	biological_process	regulation of double-strand break repair via nonhomologous end joining
c	0003779	molecular_function	actin binding
c	0005634	cellular_component	nucleus
c	0005737	cellular_component	cytoplasm
c	0005856	cellular_component	cytoskeleton
c	0005885	cellular_component	Arp2/3 protein complex
c	0015629	cellular_component	actin cytoskeleton
c	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
d	0003779	molecular_function	actin binding
d	0005200	molecular_function	structural constituent of cytoskeleton
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005737	cellular_component	cytoplasm
d	0005768	cellular_component	endosome
d	0005856	cellular_component	cytoskeleton
d	0005885	cellular_component	Arp2/3 protein complex
d	0005886	cellular_component	plasma membrane
d	0005925	cellular_component	focal adhesion
d	0010592	biological_process	positive regulation of lamellipodium assembly
d	0015629	cellular_component	actin cytoskeleton
d	0030027	cellular_component	lamellipodium
d	0030041	biological_process	actin filament polymerization
d	0030672	cellular_component	synaptic vesicle membrane
d	0030838	biological_process	positive regulation of actin filament polymerization
d	0031252	cellular_component	cell leading edge
d	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
d	0035861	cellular_component	site of double-strand break
d	0036195	cellular_component	muscle cell projection membrane
d	0042995	cellular_component	cell projection
d	0043005	cellular_component	neuron projection
d	0045202	cellular_component	synapse
d	0051015	molecular_function	actin filament binding
d	0098793	cellular_component	presynapse
d	0098794	cellular_component	postsynapse
d	0098978	cellular_component	glutamatergic synapse
d	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
e	0003779	molecular_function	actin binding
e	0005200	molecular_function	structural constituent of cytoskeleton
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005737	cellular_component	cytoplasm
e	0005856	cellular_component	cytoskeleton
e	0005885	cellular_component	Arp2/3 protein complex
e	0030027	cellular_component	lamellipodium
e	0030833	biological_process	regulation of actin filament polymerization
e	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
e	0035861	cellular_component	site of double-strand break
e	0042995	cellular_component	cell projection
e	0051015	molecular_function	actin filament binding
e	1900242	biological_process	regulation of synaptic vesicle endocytosis
f	0003779	molecular_function	actin binding
f	0005200	molecular_function	structural constituent of cytoskeleton
f	0005634	cellular_component	nucleus
f	0005737	cellular_component	cytoplasm
f	0005856	cellular_component	cytoskeleton
f	0005885	cellular_component	Arp2/3 protein complex
f	0015629	cellular_component	actin cytoskeleton
f	0019899	molecular_function	enzyme binding
f	0030041	biological_process	actin filament polymerization
f	0030674	molecular_function	protein-macromolecule adaptor activity
f	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
f	0035861	cellular_component	site of double-strand break
f	0042995	cellular_component	cell projection
f	0051015	molecular_function	actin filament binding
g	0003779	molecular_function	actin binding
g	0005200	molecular_function	structural constituent of cytoskeleton
g	0005634	cellular_component	nucleus
g	0005737	cellular_component	cytoplasm
g	0005856	cellular_component	cytoskeleton
g	0005885	cellular_component	Arp2/3 protein complex
g	0015629	cellular_component	actin cytoskeleton
g	0016477	biological_process	cell migration
g	0030027	cellular_component	lamellipodium
g	0030833	biological_process	regulation of actin filament polymerization
g	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
g	0035861	cellular_component	site of double-strand break
g	0042995	cellular_component	cell projection
g	0051015	molecular_function	actin filament binding
h	0000166	molecular_function	nucleotide binding
h	0001725	cellular_component	stress fiber
h	0005515	molecular_function	protein binding
h	0005524	molecular_function	ATP binding
h	0005737	cellular_component	cytoplasm
h	0005856	cellular_component	cytoskeleton
h	0005865	cellular_component	striated muscle thin filament
h	0005884	cellular_component	actin filament
h	0010628	biological_process	positive regulation of gene expression
h	0015629	cellular_component	actin cytoskeleton
h	0016787	molecular_function	hydrolase activity
h	0030017	cellular_component	sarcomere
h	0030027	cellular_component	lamellipodium
h	0030175	cellular_component	filopodium
h	0030240	biological_process	skeletal muscle thin filament assembly
h	0032991	cellular_component	protein-containing complex
h	0044297	cellular_component	cell body
h	0048741	biological_process	skeletal muscle fiber development
h	0090131	biological_process	mesenchyme migration
i	0000166	molecular_function	nucleotide binding
i	0001725	cellular_component	stress fiber
i	0005515	molecular_function	protein binding
i	0005524	molecular_function	ATP binding
i	0005737	cellular_component	cytoplasm
i	0005856	cellular_component	cytoskeleton
i	0005865	cellular_component	striated muscle thin filament
i	0005884	cellular_component	actin filament
i	0010628	biological_process	positive regulation of gene expression
i	0015629	cellular_component	actin cytoskeleton
i	0016787	molecular_function	hydrolase activity
i	0030017	cellular_component	sarcomere
i	0030027	cellular_component	lamellipodium
i	0030175	cellular_component	filopodium
i	0030240	biological_process	skeletal muscle thin filament assembly
i	0032991	cellular_component	protein-containing complex
i	0044297	cellular_component	cell body
i	0048741	biological_process	skeletal muscle fiber development
i	0090131	biological_process	mesenchyme migration
j	0000166	molecular_function	nucleotide binding
j	0001725	cellular_component	stress fiber
j	0005515	molecular_function	protein binding
j	0005524	molecular_function	ATP binding
j	0005737	cellular_component	cytoplasm
j	0005856	cellular_component	cytoskeleton
j	0005865	cellular_component	striated muscle thin filament
j	0005884	cellular_component	actin filament
j	0010628	biological_process	positive regulation of gene expression
j	0015629	cellular_component	actin cytoskeleton
j	0016787	molecular_function	hydrolase activity
j	0030017	cellular_component	sarcomere
j	0030027	cellular_component	lamellipodium
j	0030175	cellular_component	filopodium
j	0030240	biological_process	skeletal muscle thin filament assembly
j	0032991	cellular_component	protein-containing complex
j	0044297	cellular_component	cell body
j	0048741	biological_process	skeletal muscle fiber development
j	0090131	biological_process	mesenchyme migration
k	0000166	molecular_function	nucleotide binding
k	0001725	cellular_component	stress fiber
k	0005515	molecular_function	protein binding
k	0005524	molecular_function	ATP binding
k	0005737	cellular_component	cytoplasm
k	0005856	cellular_component	cytoskeleton
k	0005865	cellular_component	striated muscle thin filament
k	0005884	cellular_component	actin filament
k	0010628	biological_process	positive regulation of gene expression
k	0015629	cellular_component	actin cytoskeleton
k	0016787	molecular_function	hydrolase activity
k	0030017	cellular_component	sarcomere
k	0030027	cellular_component	lamellipodium
k	0030175	cellular_component	filopodium
k	0030240	biological_process	skeletal muscle thin filament assembly
k	0032991	cellular_component	protein-containing complex
k	0044297	cellular_component	cell body
k	0048741	biological_process	skeletal muscle fiber development
k	0090131	biological_process	mesenchyme migration
l	0000166	molecular_function	nucleotide binding
l	0001725	cellular_component	stress fiber
l	0005515	molecular_function	protein binding
l	0005524	molecular_function	ATP binding
l	0005737	cellular_component	cytoplasm
l	0005856	cellular_component	cytoskeleton
l	0005865	cellular_component	striated muscle thin filament
l	0005884	cellular_component	actin filament
l	0010628	biological_process	positive regulation of gene expression
l	0015629	cellular_component	actin cytoskeleton
l	0016787	molecular_function	hydrolase activity
l	0030017	cellular_component	sarcomere
l	0030027	cellular_component	lamellipodium
l	0030175	cellular_component	filopodium
l	0030240	biological_process	skeletal muscle thin filament assembly
l	0032991	cellular_component	protein-containing complex
l	0044297	cellular_component	cell body
l	0048741	biological_process	skeletal muscle fiber development
l	0090131	biological_process	mesenchyme migration
m	0000166	molecular_function	nucleotide binding
m	0001725	cellular_component	stress fiber
m	0005515	molecular_function	protein binding
m	0005524	molecular_function	ATP binding
m	0005737	cellular_component	cytoplasm
m	0005856	cellular_component	cytoskeleton
m	0005865	cellular_component	striated muscle thin filament
m	0005884	cellular_component	actin filament
m	0010628	biological_process	positive regulation of gene expression
m	0015629	cellular_component	actin cytoskeleton
m	0016787	molecular_function	hydrolase activity
m	0030017	cellular_component	sarcomere
m	0030027	cellular_component	lamellipodium
m	0030175	cellular_component	filopodium
m	0030240	biological_process	skeletal muscle thin filament assembly
m	0032991	cellular_component	protein-containing complex
m	0044297	cellular_component	cell body
m	0048741	biological_process	skeletal muscle fiber development
m	0090131	biological_process	mesenchyme migration
n	0000166	molecular_function	nucleotide binding
n	0001725	cellular_component	stress fiber
n	0005515	molecular_function	protein binding
n	0005524	molecular_function	ATP binding
n	0005737	cellular_component	cytoplasm
n	0005856	cellular_component	cytoskeleton
n	0005865	cellular_component	striated muscle thin filament
n	0005884	cellular_component	actin filament
n	0010628	biological_process	positive regulation of gene expression
n	0015629	cellular_component	actin cytoskeleton
n	0016787	molecular_function	hydrolase activity
n	0030017	cellular_component	sarcomere
n	0030027	cellular_component	lamellipodium
n	0030175	cellular_component	filopodium
n	0030240	biological_process	skeletal muscle thin filament assembly
n	0032991	cellular_component	protein-containing complex
n	0044297	cellular_component	cell body
n	0048741	biological_process	skeletal muscle fiber development
n	0090131	biological_process	mesenchyme migration
o	0000166	molecular_function	nucleotide binding
o	0001725	cellular_component	stress fiber
o	0005515	molecular_function	protein binding
o	0005524	molecular_function	ATP binding
o	0005737	cellular_component	cytoplasm
o	0005856	cellular_component	cytoskeleton
o	0005865	cellular_component	striated muscle thin filament
o	0005884	cellular_component	actin filament
o	0010628	biological_process	positive regulation of gene expression
o	0015629	cellular_component	actin cytoskeleton
o	0016787	molecular_function	hydrolase activity
o	0030017	cellular_component	sarcomere
o	0030027	cellular_component	lamellipodium
o	0030175	cellular_component	filopodium
o	0030240	biological_process	skeletal muscle thin filament assembly
o	0032991	cellular_component	protein-containing complex
o	0044297	cellular_component	cell body
o	0048741	biological_process	skeletal muscle fiber development
o	0090131	biological_process	mesenchyme migration
p	0000166	molecular_function	nucleotide binding
p	0001725	cellular_component	stress fiber
p	0005515	molecular_function	protein binding
p	0005524	molecular_function	ATP binding
p	0005737	cellular_component	cytoplasm
p	0005856	cellular_component	cytoskeleton
p	0005865	cellular_component	striated muscle thin filament
p	0005884	cellular_component	actin filament
p	0010628	biological_process	positive regulation of gene expression
p	0015629	cellular_component	actin cytoskeleton
p	0016787	molecular_function	hydrolase activity
p	0030017	cellular_component	sarcomere
p	0030027	cellular_component	lamellipodium
p	0030175	cellular_component	filopodium
p	0030240	biological_process	skeletal muscle thin filament assembly
p	0032991	cellular_component	protein-containing complex
p	0044297	cellular_component	cell body
p	0048741	biological_process	skeletal muscle fiber development
p	0090131	biological_process	mesenchyme migration
q	0000166	molecular_function	nucleotide binding
q	0001725	cellular_component	stress fiber
q	0005515	molecular_function	protein binding
q	0005524	molecular_function	ATP binding
q	0005737	cellular_component	cytoplasm
q	0005856	cellular_component	cytoskeleton
q	0005865	cellular_component	striated muscle thin filament
q	0005884	cellular_component	actin filament
q	0010628	biological_process	positive regulation of gene expression
q	0015629	cellular_component	actin cytoskeleton
q	0016787	molecular_function	hydrolase activity
q	0030017	cellular_component	sarcomere
q	0030027	cellular_component	lamellipodium
q	0030175	cellular_component	filopodium
q	0030240	biological_process	skeletal muscle thin filament assembly
q	0032991	cellular_component	protein-containing complex
q	0044297	cellular_component	cell body
q	0048741	biological_process	skeletal muscle fiber development
q	0090131	biological_process	mesenchyme migration
r	0000166	molecular_function	nucleotide binding
r	0001725	cellular_component	stress fiber
r	0005515	molecular_function	protein binding
r	0005524	molecular_function	ATP binding
r	0005737	cellular_component	cytoplasm
r	0005856	cellular_component	cytoskeleton
r	0005865	cellular_component	striated muscle thin filament
r	0005884	cellular_component	actin filament
r	0010628	biological_process	positive regulation of gene expression
r	0015629	cellular_component	actin cytoskeleton
r	0016787	molecular_function	hydrolase activity
r	0030017	cellular_component	sarcomere
r	0030027	cellular_component	lamellipodium
r	0030175	cellular_component	filopodium
r	0030240	biological_process	skeletal muscle thin filament assembly
r	0032991	cellular_component	protein-containing complex
r	0044297	cellular_component	cell body
r	0048741	biological_process	skeletal muscle fiber development
r	0090131	biological_process	mesenchyme migration

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
h	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
h	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEPpLNTpeNR

Chain	Residue	Details
a	LEU111-ARG123
h	LEU104-ARG116
b	LEU108-ARG120

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	MOD_RES: N-acetylcysteine; in intermediate form => ECO:0000269|PubMed:36173861

Chain	Residue	Details
h	CYS0
q	CYS0
r	CYS0
i	CYS0
j	CYS0
k	CYS0
l	CYS0
m	CYS0
n	CYS0
o	CYS0
p	CYS0

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	MOD_RES: Methionine (R)-sulfoxide => ECO:0000269|PubMed:23911929

Chain	Residue	Details
h	MET44
l	MET47
m	MET44
m	MET47
n	MET44
n	MET47
o	MET44
o	MET47
p	MET44
p	MET47
q	MET44
h	MET47
q	MET47
r	MET44
r	MET47
i	MET44
i	MET47
j	MET44
j	MET47
k	MET44
k	MET47
l	MET44

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	MOD_RES: N6-malonyllysine => ECO:0000250

Chain	Residue	Details
h	LYS61
q	LYS61
r	LYS61
i	LYS61
j	LYS61
k	LYS61
l	LYS61
m	LYS61
n	LYS61
o	LYS61
p	LYS61

---

site_id	SWS_FT_FI4
Number of Residues	11
Details	MOD_RES: Tele-methylhistidine => ECO:0000250|UniProtKB:P68138

Chain	Residue	Details
h	HIS73
q	HIS73
r	HIS73
i	HIS73
j	HIS73
k	HIS73
l	HIS73
m	HIS73
n	HIS73
o	HIS73
p	HIS73

---

site_id	SWS_FT_FI5
Number of Residues	11
Details	MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68133

Chain	Residue	Details
h	LYS84
q	LYS84
r	LYS84
i	LYS84
j	LYS84
k	LYS84
l	LYS84
m	LYS84
n	LYS84
o	LYS84
p	LYS84

---