7APK

Structure of the human THO - UAP56 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000346	cellular_component	transcription export complex
a	0000347	cellular_component	THO complex
a	0000445	cellular_component	THO complex part of transcription export complex
a	0000781	cellular_component	chromosome, telomeric region
a	0003677	molecular_function	DNA binding
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005737	cellular_component	cytoplasm
a	0006397	biological_process	mRNA processing
a	0006406	biological_process	mRNA export from nucleus
a	0006915	biological_process	apoptotic process
a	0007165	biological_process	signal transduction
a	0008380	biological_process	RNA splicing
a	0016363	cellular_component	nuclear matrix
a	0016607	cellular_component	nuclear speck
a	0051028	biological_process	mRNA transport
A	0000346	cellular_component	transcription export complex
A	0000347	cellular_component	THO complex
A	0000445	cellular_component	THO complex part of transcription export complex
A	0000781	cellular_component	chromosome, telomeric region
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0006397	biological_process	mRNA processing
A	0006406	biological_process	mRNA export from nucleus
A	0006915	biological_process	apoptotic process
A	0007165	biological_process	signal transduction
A	0008380	biological_process	RNA splicing
A	0016363	cellular_component	nuclear matrix
A	0016607	cellular_component	nuclear speck
A	0051028	biological_process	mRNA transport
b	0000347	cellular_component	THO complex
b	0006397	biological_process	mRNA processing
b	0006406	biological_process	mRNA export from nucleus
B	0000347	cellular_component	THO complex
B	0006397	biological_process	mRNA processing
B	0006406	biological_process	mRNA export from nucleus
c	0000346	cellular_component	transcription export complex
c	0000445	cellular_component	THO complex part of transcription export complex
c	0000781	cellular_component	chromosome, telomeric region
c	0003723	molecular_function	RNA binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0006397	biological_process	mRNA processing
c	0006406	biological_process	mRNA export from nucleus
c	0008380	biological_process	RNA splicing
c	0016607	cellular_component	nuclear speck
c	0051028	biological_process	mRNA transport
C	0000346	cellular_component	transcription export complex
C	0000445	cellular_component	THO complex part of transcription export complex
C	0000781	cellular_component	chromosome, telomeric region
C	0003723	molecular_function	RNA binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006397	biological_process	mRNA processing
C	0006406	biological_process	mRNA export from nucleus
C	0008380	biological_process	RNA splicing
C	0016607	cellular_component	nuclear speck
C	0051028	biological_process	mRNA transport
e	0000346	cellular_component	transcription export complex
e	0000347	cellular_component	THO complex
e	0000445	cellular_component	THO complex part of transcription export complex
e	0000781	cellular_component	chromosome, telomeric region
e	0003723	molecular_function	RNA binding
e	0003729	molecular_function	mRNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0006397	biological_process	mRNA processing
e	0006406	biological_process	mRNA export from nucleus
e	0008380	biological_process	RNA splicing
e	0030154	biological_process	cell differentiation
e	0030224	biological_process	monocyte differentiation
e	0051028	biological_process	mRNA transport
e	0060215	biological_process	primitive hemopoiesis
E	0000346	cellular_component	transcription export complex
E	0000347	cellular_component	THO complex
E	0000445	cellular_component	THO complex part of transcription export complex
E	0000781	cellular_component	chromosome, telomeric region
E	0003723	molecular_function	RNA binding
E	0003729	molecular_function	mRNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0006397	biological_process	mRNA processing
E	0006406	biological_process	mRNA export from nucleus
E	0008380	biological_process	RNA splicing
E	0030154	biological_process	cell differentiation
E	0030224	biological_process	monocyte differentiation
E	0051028	biological_process	mRNA transport
E	0060215	biological_process	primitive hemopoiesis
f	0000346	cellular_component	transcription export complex
f	0000347	cellular_component	THO complex
f	0000445	cellular_component	THO complex part of transcription export complex
f	0000781	cellular_component	chromosome, telomeric region
f	0003723	molecular_function	RNA binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0006397	biological_process	mRNA processing
f	0006406	biological_process	mRNA export from nucleus
f	0006915	biological_process	apoptotic process
f	0007417	biological_process	central nervous system development
f	0008380	biological_process	RNA splicing
f	0016604	cellular_component	nuclear body
f	0016607	cellular_component	nuclear speck
f	0051028	biological_process	mRNA transport
F	0000346	cellular_component	transcription export complex
F	0000347	cellular_component	THO complex
F	0000445	cellular_component	THO complex part of transcription export complex
F	0000781	cellular_component	chromosome, telomeric region
F	0003723	molecular_function	RNA binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0006397	biological_process	mRNA processing
F	0006406	biological_process	mRNA export from nucleus
F	0006915	biological_process	apoptotic process
F	0007417	biological_process	central nervous system development
F	0008380	biological_process	RNA splicing
F	0016604	cellular_component	nuclear body
F	0016607	cellular_component	nuclear speck
F	0051028	biological_process	mRNA transport
g	0000346	cellular_component	transcription export complex
g	0000347	cellular_component	THO complex
g	0000445	cellular_component	THO complex part of transcription export complex
g	0000781	cellular_component	chromosome, telomeric region
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0006397	biological_process	mRNA processing
g	0006406	biological_process	mRNA export from nucleus
g	0008380	biological_process	RNA splicing
g	0016607	cellular_component	nuclear speck
g	0051028	biological_process	mRNA transport
G	0000346	cellular_component	transcription export complex
G	0000347	cellular_component	THO complex
G	0000445	cellular_component	THO complex part of transcription export complex
G	0000781	cellular_component	chromosome, telomeric region
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006397	biological_process	mRNA processing
G	0006406	biological_process	mRNA export from nucleus
G	0008380	biological_process	RNA splicing
G	0016607	cellular_component	nuclear speck
G	0051028	biological_process	mRNA transport
h	0000245	biological_process	spliceosomal complex assembly
h	0000346	cellular_component	transcription export complex
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003676	molecular_function	nucleic acid binding
h	0003723	molecular_function	RNA binding
h	0003724	molecular_function	RNA helicase activity
h	0003729	molecular_function	mRNA binding
h	0004386	molecular_function	helicase activity
h	0005515	molecular_function	protein binding
h	0005524	molecular_function	ATP binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005681	cellular_component	spliceosomal complex
h	0005687	cellular_component	U4 snRNP
h	0005688	cellular_component	U6 snRNP
h	0005737	cellular_component	cytoplasm
h	0006397	biological_process	mRNA processing
h	0006405	biological_process	RNA export from nucleus
h	0006406	biological_process	mRNA export from nucleus
h	0008186	molecular_function	ATP-dependent activity, acting on RNA
h	0008380	biological_process	RNA splicing
h	0010501	biological_process	RNA secondary structure unwinding
h	0016607	cellular_component	nuclear speck
h	0016787	molecular_function	hydrolase activity
h	0016887	molecular_function	ATP hydrolysis activity
h	0017070	molecular_function	U6 snRNA binding
h	0030621	molecular_function	U4 snRNA binding
h	0042802	molecular_function	identical protein binding
h	0043008	molecular_function	ATP-dependent protein binding
h	0051028	biological_process	mRNA transport
H	0000245	biological_process	spliceosomal complex assembly
H	0000346	cellular_component	transcription export complex
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0003676	molecular_function	nucleic acid binding
H	0003723	molecular_function	RNA binding
H	0003724	molecular_function	RNA helicase activity
H	0003729	molecular_function	mRNA binding
H	0004386	molecular_function	helicase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005681	cellular_component	spliceosomal complex
H	0005687	cellular_component	U4 snRNP
H	0005688	cellular_component	U6 snRNP
H	0005737	cellular_component	cytoplasm
H	0006397	biological_process	mRNA processing
H	0006405	biological_process	RNA export from nucleus
H	0006406	biological_process	mRNA export from nucleus
H	0008186	molecular_function	ATP-dependent activity, acting on RNA
H	0008380	biological_process	RNA splicing
H	0010501	biological_process	RNA secondary structure unwinding
H	0016607	cellular_component	nuclear speck
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0017070	molecular_function	U6 snRNA binding
H	0030621	molecular_function	U4 snRNA binding
H	0042802	molecular_function	identical protein binding
H	0043008	molecular_function	ATP-dependent protein binding
H	0051028	biological_process	mRNA transport
i	0000346	cellular_component	transcription export complex
i	0000347	cellular_component	THO complex
i	0000445	cellular_component	THO complex part of transcription export complex
i	0000781	cellular_component	chromosome, telomeric region
i	0003677	molecular_function	DNA binding
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0006397	biological_process	mRNA processing
i	0006406	biological_process	mRNA export from nucleus
i	0006915	biological_process	apoptotic process
i	0007165	biological_process	signal transduction
i	0008380	biological_process	RNA splicing
i	0016363	cellular_component	nuclear matrix
i	0016607	cellular_component	nuclear speck
i	0051028	biological_process	mRNA transport
I	0000346	cellular_component	transcription export complex
I	0000347	cellular_component	THO complex
I	0000445	cellular_component	THO complex part of transcription export complex
I	0000781	cellular_component	chromosome, telomeric region
I	0003677	molecular_function	DNA binding
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0006397	biological_process	mRNA processing
I	0006406	biological_process	mRNA export from nucleus
I	0006915	biological_process	apoptotic process
I	0007165	biological_process	signal transduction
I	0008380	biological_process	RNA splicing
I	0016363	cellular_component	nuclear matrix
I	0016607	cellular_component	nuclear speck
I	0051028	biological_process	mRNA transport
j	0000347	cellular_component	THO complex
j	0006397	biological_process	mRNA processing
j	0006406	biological_process	mRNA export from nucleus
J	0000347	cellular_component	THO complex
J	0006397	biological_process	mRNA processing
J	0006406	biological_process	mRNA export from nucleus
k	0000346	cellular_component	transcription export complex
k	0000445	cellular_component	THO complex part of transcription export complex
k	0000781	cellular_component	chromosome, telomeric region
k	0003723	molecular_function	RNA binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0006397	biological_process	mRNA processing
k	0006406	biological_process	mRNA export from nucleus
k	0008380	biological_process	RNA splicing
k	0016607	cellular_component	nuclear speck
k	0051028	biological_process	mRNA transport
K	0000346	cellular_component	transcription export complex
K	0000445	cellular_component	THO complex part of transcription export complex
K	0000781	cellular_component	chromosome, telomeric region
K	0003723	molecular_function	RNA binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0006397	biological_process	mRNA processing
K	0006406	biological_process	mRNA export from nucleus
K	0008380	biological_process	RNA splicing
K	0016607	cellular_component	nuclear speck
K	0051028	biological_process	mRNA transport
m	0000346	cellular_component	transcription export complex
m	0000347	cellular_component	THO complex
m	0000445	cellular_component	THO complex part of transcription export complex
m	0000781	cellular_component	chromosome, telomeric region
m	0003723	molecular_function	RNA binding
m	0003729	molecular_function	mRNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005737	cellular_component	cytoplasm
m	0006397	biological_process	mRNA processing
m	0006406	biological_process	mRNA export from nucleus
m	0008380	biological_process	RNA splicing
m	0030154	biological_process	cell differentiation
m	0030224	biological_process	monocyte differentiation
m	0051028	biological_process	mRNA transport
m	0060215	biological_process	primitive hemopoiesis
M	0000346	cellular_component	transcription export complex
M	0000347	cellular_component	THO complex
M	0000445	cellular_component	THO complex part of transcription export complex
M	0000781	cellular_component	chromosome, telomeric region
M	0003723	molecular_function	RNA binding
M	0003729	molecular_function	mRNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0006397	biological_process	mRNA processing
M	0006406	biological_process	mRNA export from nucleus
M	0008380	biological_process	RNA splicing
M	0030154	biological_process	cell differentiation
M	0030224	biological_process	monocyte differentiation
M	0051028	biological_process	mRNA transport
M	0060215	biological_process	primitive hemopoiesis
n	0000346	cellular_component	transcription export complex
n	0000347	cellular_component	THO complex
n	0000445	cellular_component	THO complex part of transcription export complex
n	0000781	cellular_component	chromosome, telomeric region
n	0003723	molecular_function	RNA binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0006397	biological_process	mRNA processing
n	0006406	biological_process	mRNA export from nucleus
n	0006915	biological_process	apoptotic process
n	0007417	biological_process	central nervous system development
n	0008380	biological_process	RNA splicing
n	0016604	cellular_component	nuclear body
n	0016607	cellular_component	nuclear speck
n	0051028	biological_process	mRNA transport
N	0000346	cellular_component	transcription export complex
N	0000347	cellular_component	THO complex
N	0000445	cellular_component	THO complex part of transcription export complex
N	0000781	cellular_component	chromosome, telomeric region
N	0003723	molecular_function	RNA binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0006397	biological_process	mRNA processing
N	0006406	biological_process	mRNA export from nucleus
N	0006915	biological_process	apoptotic process
N	0007417	biological_process	central nervous system development
N	0008380	biological_process	RNA splicing
N	0016604	cellular_component	nuclear body
N	0016607	cellular_component	nuclear speck
N	0051028	biological_process	mRNA transport
o	0000346	cellular_component	transcription export complex
o	0000347	cellular_component	THO complex
o	0000445	cellular_component	THO complex part of transcription export complex
o	0000781	cellular_component	chromosome, telomeric region
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005737	cellular_component	cytoplasm
o	0005829	cellular_component	cytosol
o	0006397	biological_process	mRNA processing
o	0006406	biological_process	mRNA export from nucleus
o	0008380	biological_process	RNA splicing
o	0016607	cellular_component	nuclear speck
o	0051028	biological_process	mRNA transport
O	0000346	cellular_component	transcription export complex
O	0000347	cellular_component	THO complex
O	0000445	cellular_component	THO complex part of transcription export complex
O	0000781	cellular_component	chromosome, telomeric region
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006397	biological_process	mRNA processing
O	0006406	biological_process	mRNA export from nucleus
O	0008380	biological_process	RNA splicing
O	0016607	cellular_component	nuclear speck
O	0051028	biological_process	mRNA transport
p	0000245	biological_process	spliceosomal complex assembly
p	0000346	cellular_component	transcription export complex
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0003676	molecular_function	nucleic acid binding
p	0003723	molecular_function	RNA binding
p	0003724	molecular_function	RNA helicase activity
p	0003729	molecular_function	mRNA binding
p	0004386	molecular_function	helicase activity
p	0005515	molecular_function	protein binding
p	0005524	molecular_function	ATP binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005681	cellular_component	spliceosomal complex
p	0005687	cellular_component	U4 snRNP
p	0005688	cellular_component	U6 snRNP
p	0005737	cellular_component	cytoplasm
p	0006397	biological_process	mRNA processing
p	0006405	biological_process	RNA export from nucleus
p	0006406	biological_process	mRNA export from nucleus
p	0008186	molecular_function	ATP-dependent activity, acting on RNA
p	0008380	biological_process	RNA splicing
p	0010501	biological_process	RNA secondary structure unwinding
p	0016607	cellular_component	nuclear speck
p	0016787	molecular_function	hydrolase activity
p	0016887	molecular_function	ATP hydrolysis activity
p	0017070	molecular_function	U6 snRNA binding
p	0030621	molecular_function	U4 snRNA binding
p	0042802	molecular_function	identical protein binding
p	0043008	molecular_function	ATP-dependent protein binding
p	0051028	biological_process	mRNA transport
P	0000245	biological_process	spliceosomal complex assembly
P	0000346	cellular_component	transcription export complex
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003676	molecular_function	nucleic acid binding
P	0003723	molecular_function	RNA binding
P	0003724	molecular_function	RNA helicase activity
P	0003729	molecular_function	mRNA binding
P	0004386	molecular_function	helicase activity
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005681	cellular_component	spliceosomal complex
P	0005687	cellular_component	U4 snRNP
P	0005688	cellular_component	U6 snRNP
P	0005737	cellular_component	cytoplasm
P	0006397	biological_process	mRNA processing
P	0006405	biological_process	RNA export from nucleus
P	0006406	biological_process	mRNA export from nucleus
P	0008186	molecular_function	ATP-dependent activity, acting on RNA
P	0008380	biological_process	RNA splicing
P	0010501	biological_process	RNA secondary structure unwinding
P	0016607	cellular_component	nuclear speck
P	0016787	molecular_function	hydrolase activity
P	0016887	molecular_function	ATP hydrolysis activity
P	0017070	molecular_function	U6 snRNA binding
P	0030621	molecular_function	U4 snRNA binding
P	0042802	molecular_function	identical protein binding
P	0043008	molecular_function	ATP-dependent protein binding
P	0051028	biological_process	mRNA transport

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VLSGgeDgAVRLWDL

Chain	Residue	Details
n	VAL183-LEU197

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
H	ALA89
P	ALA89
h	ALA89
p	ALA89

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895

Chain	Residue	Details
H	ALA2
P	ALA2
h	ALA2
p	ALA2
e	SER5
e	SER6
m	SER5
m	SER6

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
H	LYS36
P	LYS36
h	LYS36
p	LYS36
a	LYS133
a	LYS300
i	LYS133
i	LYS300

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
H	SER38
P	SER38
h	SER38
p	SER38

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
H	SER41
P	SER41
h	SER41
p	SER41
e	SER312
e	SER314
m	SER312
m	SER314

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
H	THR172
P	THR172
h	THR172
p	THR172

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
H	LYS36
A	LYS595
P	LYS36
I	LYS595
h	LYS36
a	LYS595
p	LYS36
i	LYS595

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447

Chain	Residue	Details
A	LYS408
I	LYS408
a	LYS408
i	LYS408

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS580
I	LYS580
a	LYS580
i	LYS580

---