Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7ALQ

human GCH-GFRP inhibitory complex 7-deaza-GTP bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0003934	molecular_function	GTP cyclohydrolase I activity
F	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0003934	molecular_function	GTP cyclohydrolase I activity
G	0046654	biological_process	tetrahydrofolate biosynthetic process
H	0003934	molecular_function	GTP cyclohydrolase I activity
H	0046654	biological_process	tetrahydrofolate biosynthetic process
I	0003934	molecular_function	GTP cyclohydrolase I activity
I	0046654	biological_process	tetrahydrofolate biosynthetic process
J	0003934	molecular_function	GTP cyclohydrolase I activity
J	0046654	biological_process	tetrahydrofolate biosynthetic process
K	0003934	molecular_function	GTP cyclohydrolase I activity
K	0046654	biological_process	tetrahydrofolate biosynthetic process
L	0003934	molecular_function	GTP cyclohydrolase I activity
L	0046654	biological_process	tetrahydrofolate biosynthetic process
M	0003934	molecular_function	GTP cyclohydrolase I activity
M	0046654	biological_process	tetrahydrofolate biosynthetic process
N	0003934	molecular_function	GTP cyclohydrolase I activity
N	0046654	biological_process	tetrahydrofolate biosynthetic process
O	0003934	molecular_function	GTP cyclohydrolase I activity
O	0046654	biological_process	tetrahydrofolate biosynthetic process
P	0003934	molecular_function	GTP cyclohydrolase I activity
P	0046654	biological_process	tetrahydrofolate biosynthetic process
Q	0003934	molecular_function	GTP cyclohydrolase I activity
Q	0046654	biological_process	tetrahydrofolate biosynthetic process
R	0003934	molecular_function	GTP cyclohydrolase I activity
R	0046654	biological_process	tetrahydrofolate biosynthetic process
S	0003934	molecular_function	GTP cyclohydrolase I activity
S	0046654	biological_process	tetrahydrofolate biosynthetic process
T	0003934	molecular_function	GTP cyclohydrolase I activity
T	0046654	biological_process	tetrahydrofolate biosynthetic process
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0009890	biological_process	negative regulation of biosynthetic process
a	0016020	cellular_component	membrane
a	0030425	cellular_component	dendrite
a	0031965	cellular_component	nuclear membrane
a	0042470	cellular_component	melanosome
a	0044549	molecular_function	GTP cyclohydrolase binding
a	0045428	biological_process	regulation of nitric oxide biosynthetic process
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0009890	biological_process	negative regulation of biosynthetic process
b	0016020	cellular_component	membrane
b	0030425	cellular_component	dendrite
b	0031965	cellular_component	nuclear membrane
b	0042470	cellular_component	melanosome
b	0044549	molecular_function	GTP cyclohydrolase binding
b	0045428	biological_process	regulation of nitric oxide biosynthetic process
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0009890	biological_process	negative regulation of biosynthetic process
c	0016020	cellular_component	membrane
c	0030425	cellular_component	dendrite
c	0031965	cellular_component	nuclear membrane
c	0042470	cellular_component	melanosome
c	0044549	molecular_function	GTP cyclohydrolase binding
c	0045428	biological_process	regulation of nitric oxide biosynthetic process
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0009890	biological_process	negative regulation of biosynthetic process
d	0016020	cellular_component	membrane
d	0030425	cellular_component	dendrite
d	0031965	cellular_component	nuclear membrane
d	0042470	cellular_component	melanosome
d	0044549	molecular_function	GTP cyclohydrolase binding
d	0045428	biological_process	regulation of nitric oxide biosynthetic process
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0009890	biological_process	negative regulation of biosynthetic process
e	0016020	cellular_component	membrane
e	0030425	cellular_component	dendrite
e	0031965	cellular_component	nuclear membrane
e	0042470	cellular_component	melanosome
e	0044549	molecular_function	GTP cyclohydrolase binding
e	0045428	biological_process	regulation of nitric oxide biosynthetic process
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0009890	biological_process	negative regulation of biosynthetic process
f	0016020	cellular_component	membrane
f	0030425	cellular_component	dendrite
f	0031965	cellular_component	nuclear membrane
f	0042470	cellular_component	melanosome
f	0044549	molecular_function	GTP cyclohydrolase binding
f	0045428	biological_process	regulation of nitric oxide biosynthetic process
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0009890	biological_process	negative regulation of biosynthetic process
g	0016020	cellular_component	membrane
g	0030425	cellular_component	dendrite
g	0031965	cellular_component	nuclear membrane
g	0042470	cellular_component	melanosome
g	0044549	molecular_function	GTP cyclohydrolase binding
g	0045428	biological_process	regulation of nitric oxide biosynthetic process
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0009890	biological_process	negative regulation of biosynthetic process
h	0016020	cellular_component	membrane
h	0030425	cellular_component	dendrite
h	0031965	cellular_component	nuclear membrane
h	0042470	cellular_component	melanosome
h	0044549	molecular_function	GTP cyclohydrolase binding
h	0045428	biological_process	regulation of nitric oxide biosynthetic process
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0009890	biological_process	negative regulation of biosynthetic process
i	0016020	cellular_component	membrane
i	0030425	cellular_component	dendrite
i	0031965	cellular_component	nuclear membrane
i	0042470	cellular_component	melanosome
i	0044549	molecular_function	GTP cyclohydrolase binding
i	0045428	biological_process	regulation of nitric oxide biosynthetic process
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0009890	biological_process	negative regulation of biosynthetic process
j	0016020	cellular_component	membrane
j	0030425	cellular_component	dendrite
j	0031965	cellular_component	nuclear membrane
j	0042470	cellular_component	melanosome
j	0044549	molecular_function	GTP cyclohydrolase binding
j	0045428	biological_process	regulation of nitric oxide biosynthetic process
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0009890	biological_process	negative regulation of biosynthetic process
k	0016020	cellular_component	membrane
k	0030425	cellular_component	dendrite
k	0031965	cellular_component	nuclear membrane
k	0042470	cellular_component	melanosome
k	0044549	molecular_function	GTP cyclohydrolase binding
k	0045428	biological_process	regulation of nitric oxide biosynthetic process
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0009890	biological_process	negative regulation of biosynthetic process
l	0016020	cellular_component	membrane
l	0030425	cellular_component	dendrite
l	0031965	cellular_component	nuclear membrane
l	0042470	cellular_component	melanosome
l	0044549	molecular_function	GTP cyclohydrolase binding
l	0045428	biological_process	regulation of nitric oxide biosynthetic process
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0009890	biological_process	negative regulation of biosynthetic process
m	0016020	cellular_component	membrane
m	0030425	cellular_component	dendrite
m	0031965	cellular_component	nuclear membrane
m	0042470	cellular_component	melanosome
m	0044549	molecular_function	GTP cyclohydrolase binding
m	0045428	biological_process	regulation of nitric oxide biosynthetic process
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0009890	biological_process	negative regulation of biosynthetic process
n	0016020	cellular_component	membrane
n	0030425	cellular_component	dendrite
n	0031965	cellular_component	nuclear membrane
n	0042470	cellular_component	melanosome
n	0044549	molecular_function	GTP cyclohydrolase binding
n	0045428	biological_process	regulation of nitric oxide biosynthetic process
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005737	cellular_component	cytoplasm
o	0005829	cellular_component	cytosol
o	0009890	biological_process	negative regulation of biosynthetic process
o	0016020	cellular_component	membrane
o	0030425	cellular_component	dendrite
o	0031965	cellular_component	nuclear membrane
o	0042470	cellular_component	melanosome
o	0044549	molecular_function	GTP cyclohydrolase binding
o	0045428	biological_process	regulation of nitric oxide biosynthetic process
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005737	cellular_component	cytoplasm
p	0005829	cellular_component	cytosol
p	0009890	biological_process	negative regulation of biosynthetic process
p	0016020	cellular_component	membrane
p	0030425	cellular_component	dendrite
p	0031965	cellular_component	nuclear membrane
p	0042470	cellular_component	melanosome
p	0044549	molecular_function	GTP cyclohydrolase binding
p	0045428	biological_process	regulation of nitric oxide biosynthetic process
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005737	cellular_component	cytoplasm
q	0005829	cellular_component	cytosol
q	0009890	biological_process	negative regulation of biosynthetic process
q	0016020	cellular_component	membrane
q	0030425	cellular_component	dendrite
q	0031965	cellular_component	nuclear membrane
q	0042470	cellular_component	melanosome
q	0044549	molecular_function	GTP cyclohydrolase binding
q	0045428	biological_process	regulation of nitric oxide biosynthetic process
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005737	cellular_component	cytoplasm
r	0005829	cellular_component	cytosol
r	0009890	biological_process	negative regulation of biosynthetic process
r	0016020	cellular_component	membrane
r	0030425	cellular_component	dendrite
r	0031965	cellular_component	nuclear membrane
r	0042470	cellular_component	melanosome
r	0044549	molecular_function	GTP cyclohydrolase binding
r	0045428	biological_process	regulation of nitric oxide biosynthetic process
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005737	cellular_component	cytoplasm
s	0005829	cellular_component	cytosol
s	0009890	biological_process	negative regulation of biosynthetic process
s	0016020	cellular_component	membrane
s	0030425	cellular_component	dendrite
s	0031965	cellular_component	nuclear membrane
s	0042470	cellular_component	melanosome
s	0044549	molecular_function	GTP cyclohydrolase binding
s	0045428	biological_process	regulation of nitric oxide biosynthetic process
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005737	cellular_component	cytoplasm
t	0005829	cellular_component	cytosol
t	0009890	biological_process	negative regulation of biosynthetic process
t	0016020	cellular_component	membrane
t	0030425	cellular_component	dendrite
t	0031965	cellular_component	nuclear membrane
t	0042470	cellular_component	melanosome
t	0044549	molecular_function	GTP cyclohydrolase binding
t	0045428	biological_process	regulation of nitric oxide biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. EMVivKDIdmfSmCEHH

Chain	Residue	Details
A	GLU128-HIS144

site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. SrRlQVQERLT

Chain	Residue	Details
A	SER176-THR186

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	BINDING: BINDING => ECO:0000269\|PubMed:11087827

Chain	Residue	Details
C	CYS141
C	HIS144
C	CYS212
D	CYS141
D	HIS144
D	CYS212
E	CYS141
E	HIS144
E	CYS212
F	CYS141
F	HIS144
F	CYS212
G	CYS141
G	HIS144
G	CYS212
H	CYS141
H	HIS144
H	CYS212
I	CYS141
I	HIS144
I	CYS212
J	CYS141
J	HIS144
J	CYS212
K	CYS141
K	HIS144
K	CYS212
L	CYS141
L	HIS144
L	CYS212
M	CYS141
M	HIS144
M	CYS212
N	CYS141
N	HIS144
N	CYS212
O	CYS141
O	HIS144
O	CYS212
P	CYS141
P	HIS144
P	CYS212
Q	CYS141
Q	HIS144
Q	CYS212
R	CYS141
R	HIS144
R	CYS212
S	CYS141
S	HIS144
S	CYS212
T	CYS141
T	HIS144
T	CYS212
A	CYS141
A	HIS144
A	CYS212
B	CYS141
B	HIS144
B	CYS212

site_id	SWS_FT_FI2
Number of Residues	20
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19690332

Chain	Residue	Details
E	SER60
F	SER60
G	SER60
H	SER60
I	SER60
J	SER60
K	SER60
L	SER60
M	SER60
N	SER60
O	SER60
P	SER60
Q	SER60
R	SER60
S	SER60
T	SER60
A	SER60
B	SER60
C	SER60
D	SER60

site_id	SWS_FT_FI3
Number of Residues	20
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:17704208

Chain	Residue	Details
A	SER81
B	SER81
C	SER81
D	SER81
E	SER81
F	SER81
G	SER81
H	SER81
I	SER81
J	SER81
K	SER81
L	SER81
M	SER81
N	SER81
O	SER81
P	SER81
Q	SER81
R	SER81
S	SER81
T	SER81

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)