7ALE
Crystal structure of human PAICS in complex with inhibitor 69
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
A | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006164 | biological_process | purine nucleotide biosynthetic process |
A | 0006177 | biological_process | GMP biosynthetic process |
A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
A | 0009113 | biological_process | purine nucleobase biosynthetic process |
A | 0016020 | cellular_component | membrane |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0016874 | molecular_function | ligase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0043727 | molecular_function | 5-amino-4-imidazole carboxylate lyase activity |
A | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
A | 0045296 | molecular_function | cadherin binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
B | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
B | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006164 | biological_process | purine nucleotide biosynthetic process |
B | 0006177 | biological_process | GMP biosynthetic process |
B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
B | 0009113 | biological_process | purine nucleobase biosynthetic process |
B | 0016020 | cellular_component | membrane |
B | 0016831 | molecular_function | carboxy-lyase activity |
B | 0016874 | molecular_function | ligase activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0043727 | molecular_function | 5-amino-4-imidazole carboxylate lyase activity |
B | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
B | 0045296 | molecular_function | cadherin binding |
B | 0070062 | cellular_component | extracellular exosome |
B | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | binding site for residue RLK A 501 |
Chain | Residue |
A | LEU13 |
A | MET93 |
A | ASP207 |
A | TYR14 |
A | LEU33 |
A | ALA76 |
A | PHE86 |
A | ALA88 |
A | PRO89 |
A | GLN90 |
A | CYS91 |
site_id | AC2 |
Number of Residues | 12 |
Details | binding site for residue OK8 A 502 |
Chain | Residue |
A | THR40 |
A | GLY42 |
A | GLU97 |
A | ARG101 |
A | SER107 |
A | ASP189 |
A | ASP212 |
A | SER213 |
A | TRP214 |
A | ARG215 |
A | LYS228 |
A | ARG232 |
site_id | AC3 |
Number of Residues | 12 |
Details | binding site for residue RLK B 501 |
Chain | Residue |
B | LEU13 |
B | TYR14 |
B | PHE65 |
B | ALA76 |
B | ALA88 |
B | PRO89 |
B | GLN90 |
B | CYS91 |
B | GLU92 |
B | MET93 |
B | ALA206 |
B | ASP207 |
site_id | AC4 |
Number of Residues | 15 |
Details | binding site for residue OK8 B 502 |
Chain | Residue |
B | LYS17 |
B | THR40 |
B | ALA41 |
B | GLY42 |
B | GLU97 |
B | ARG101 |
B | SER107 |
B | ASP189 |
B | LYS191 |
B | ASP212 |
B | SER213 |
B | TRP214 |
B | ARG215 |
B | LYS228 |
B | ARG232 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17224163, ECO:0007744|PDB:2H31 |
Chain | Residue | Details |
A | SER332 | |
B | SER332 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 |
Chain | Residue | Details |
A | ALA2 | |
B | ALA2 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9DCL9 |
Chain | Residue | Details |
A | TYR22 | |
B | TYR22 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER27 | |
B | SER27 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DCL9 |
Chain | Residue | Details |
A | LYS36 | |
B | LYS36 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER107 | |
B | SER107 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | THR238 | |
B | THR238 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS247 | |
B | LYS247 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER274 | |
B | SER274 |