7ALC

human GCH-GFRP stimulatory complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0004857	molecular_function	enzyme inhibitor activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009890	biological_process	negative regulation of biosynthetic process
F	0030425	cellular_component	dendrite
F	0031965	cellular_component	nuclear membrane
F	0042470	cellular_component	melanosome
F	0044549	molecular_function	GTP cyclohydrolase binding
F	0045428	biological_process	regulation of nitric oxide biosynthetic process
F	0060308	molecular_function	GTP cyclohydrolase I regulator activity
F	0062014	biological_process	negative regulation of small molecule metabolic process
G	0004857	molecular_function	enzyme inhibitor activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0009890	biological_process	negative regulation of biosynthetic process
G	0030425	cellular_component	dendrite
G	0031965	cellular_component	nuclear membrane
G	0042470	cellular_component	melanosome
G	0044549	molecular_function	GTP cyclohydrolase binding
G	0045428	biological_process	regulation of nitric oxide biosynthetic process
G	0060308	molecular_function	GTP cyclohydrolase I regulator activity
G	0062014	biological_process	negative regulation of small molecule metabolic process
H	0004857	molecular_function	enzyme inhibitor activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0009890	biological_process	negative regulation of biosynthetic process
H	0030425	cellular_component	dendrite
H	0031965	cellular_component	nuclear membrane
H	0042470	cellular_component	melanosome
H	0044549	molecular_function	GTP cyclohydrolase binding
H	0045428	biological_process	regulation of nitric oxide biosynthetic process
H	0060308	molecular_function	GTP cyclohydrolase I regulator activity
H	0062014	biological_process	negative regulation of small molecule metabolic process
I	0004857	molecular_function	enzyme inhibitor activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0009890	biological_process	negative regulation of biosynthetic process
I	0030425	cellular_component	dendrite
I	0031965	cellular_component	nuclear membrane
I	0042470	cellular_component	melanosome
I	0044549	molecular_function	GTP cyclohydrolase binding
I	0045428	biological_process	regulation of nitric oxide biosynthetic process
I	0060308	molecular_function	GTP cyclohydrolase I regulator activity
I	0062014	biological_process	negative regulation of small molecule metabolic process
J	0004857	molecular_function	enzyme inhibitor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0009890	biological_process	negative regulation of biosynthetic process
J	0030425	cellular_component	dendrite
J	0031965	cellular_component	nuclear membrane
J	0042470	cellular_component	melanosome
J	0044549	molecular_function	GTP cyclohydrolase binding
J	0045428	biological_process	regulation of nitric oxide biosynthetic process
J	0060308	molecular_function	GTP cyclohydrolase I regulator activity
J	0062014	biological_process	negative regulation of small molecule metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. EMVivKDIdmfSmCEHH

Chain	Residue	Details
A	GLU128-HIS144

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site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. SrRlQVQERLT

Chain	Residue	Details
A	SER176-THR186

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11087827","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17704208","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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