Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

7ALC

human GCH-GFRP stimulatory complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003934molecular_functionGTP cyclohydrolase I activity
A0046654biological_processtetrahydrofolate biosynthetic process
B0003934molecular_functionGTP cyclohydrolase I activity
B0046654biological_processtetrahydrofolate biosynthetic process
C0003934molecular_functionGTP cyclohydrolase I activity
C0046654biological_processtetrahydrofolate biosynthetic process
D0003934molecular_functionGTP cyclohydrolase I activity
D0046654biological_processtetrahydrofolate biosynthetic process
E0003934molecular_functionGTP cyclohydrolase I activity
E0046654biological_processtetrahydrofolate biosynthetic process
F0004857molecular_functionenzyme inhibitor activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0009890biological_processnegative regulation of biosynthetic process
F0016020cellular_componentmembrane
F0030425cellular_componentdendrite
F0031965cellular_componentnuclear membrane
F0042470cellular_componentmelanosome
F0044549molecular_functionGTP cyclohydrolase binding
F0045428biological_processregulation of nitric oxide biosynthetic process
F0060308molecular_functionGTP cyclohydrolase I regulator activity
F0062014biological_processnegative regulation of small molecule metabolic process
G0004857molecular_functionenzyme inhibitor activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0009890biological_processnegative regulation of biosynthetic process
G0016020cellular_componentmembrane
G0030425cellular_componentdendrite
G0031965cellular_componentnuclear membrane
G0042470cellular_componentmelanosome
G0044549molecular_functionGTP cyclohydrolase binding
G0045428biological_processregulation of nitric oxide biosynthetic process
G0060308molecular_functionGTP cyclohydrolase I regulator activity
G0062014biological_processnegative regulation of small molecule metabolic process
H0004857molecular_functionenzyme inhibitor activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0009890biological_processnegative regulation of biosynthetic process
H0016020cellular_componentmembrane
H0030425cellular_componentdendrite
H0031965cellular_componentnuclear membrane
H0042470cellular_componentmelanosome
H0044549molecular_functionGTP cyclohydrolase binding
H0045428biological_processregulation of nitric oxide biosynthetic process
H0060308molecular_functionGTP cyclohydrolase I regulator activity
H0062014biological_processnegative regulation of small molecule metabolic process
I0004857molecular_functionenzyme inhibitor activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0009890biological_processnegative regulation of biosynthetic process
I0016020cellular_componentmembrane
I0030425cellular_componentdendrite
I0031965cellular_componentnuclear membrane
I0042470cellular_componentmelanosome
I0044549molecular_functionGTP cyclohydrolase binding
I0045428biological_processregulation of nitric oxide biosynthetic process
I0060308molecular_functionGTP cyclohydrolase I regulator activity
I0062014biological_processnegative regulation of small molecule metabolic process
J0004857molecular_functionenzyme inhibitor activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0009890biological_processnegative regulation of biosynthetic process
J0016020cellular_componentmembrane
J0030425cellular_componentdendrite
J0031965cellular_componentnuclear membrane
J0042470cellular_componentmelanosome
J0044549molecular_functionGTP cyclohydrolase binding
J0045428biological_processregulation of nitric oxide biosynthetic process
J0060308molecular_functionGTP cyclohydrolase I regulator activity
J0062014biological_processnegative regulation of small molecule metabolic process
Functional Information from PROSITE/UniProt
site_idPS00859
Number of Residues17
DetailsGTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. EMVivKDIdmfSmCEHH
ChainResidueDetails
AGLU128-HIS144

site_idPS00860
Number of Residues11
DetailsGTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. SrRlQVQERLT
ChainResidueDetails
ASER176-THR186

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues15
DetailsBINDING: BINDING => ECO:0000269|PubMed:11087827
ChainResidueDetails
ACYS141
DCYS141
DHIS144
DCYS212
ECYS141
EHIS144
ECYS212
AHIS144
ACYS212
BCYS141
BHIS144
BCYS212
CCYS141
CHIS144
CCYS212

site_idSWS_FT_FI2
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ASER60
BSER60
CSER60
DSER60
ESER60

site_idSWS_FT_FI3
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:17704208
ChainResidueDetails
ASER81
BSER81
CSER81
DSER81
ESER81

237735

PDB entries from 2025-06-18

PDB statisticsPDBj update infoContact PDBjnumon