7AL4
Ancestral Flavin-containing monooxygenase (FMO) 1 (mammalian)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
| C | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0050661 | molecular_function | NADP binding |
| D | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue FAD D 601 |
| Chain | Residue |
| D | GLY9 |
| D | LEU40 |
| D | TRP41 |
| D | GLY50 |
| D | LEU54 |
| D | SER60 |
| D | ASN61 |
| D | SER62 |
| D | THR108 |
| D | VAL110 |
| D | CYS146 |
| D | GLY11 |
| D | THR147 |
| D | SER377 |
| D | ILE378 |
| D | NAP602 |
| D | GOL606 |
| D | VAL12 |
| D | SER13 |
| D | PHE31 |
| D | GLU32 |
| D | ARG33 |
| D | GLY38 |
| D | GLY39 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | binding site for residue NAP D 602 |
| Chain | Residue |
| D | TYR55 |
| D | VAL59 |
| D | ASN61 |
| D | PRO156 |
| D | PHE160 |
| D | GLY191 |
| D | MET192 |
| D | GLY193 |
| D | ASN194 |
| D | SER195 |
| D | ASP198 |
| D | THR214 |
| D | THR215 |
| D | ARG223 |
| D | ARG280 |
| D | GLU281 |
| D | LEU284 |
| D | ALA328 |
| D | THR329 |
| D | GLY330 |
| D | FAD601 |
| D | GOL604 |
| D | GOL606 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue LMT D 603 |
| Chain | Residue |
| D | ARG238 |
| D | MET242 |
| D | SER246 |
| D | PHE420 |
| D | LYS446 |
| D | LEU449 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 604 |
| Chain | Residue |
| D | TYR154 |
| D | THR329 |
| D | GLY330 |
| D | TYR331 |
| D | LYS373 |
| D | NAP602 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 605 |
| Chain | Residue |
| D | LYS177 |
| D | HIS178 |
| D | ILE181 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 606 |
| Chain | Residue |
| D | ASN61 |
| D | GLY376 |
| D | FAD601 |
| D | NAP602 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | binding site for residue FAD C 601 |
| Chain | Residue |
| C | GLY9 |
| C | GLY11 |
| C | VAL12 |
| C | SER13 |
| C | PHE31 |
| C | GLU32 |
| C | ARG33 |
| C | GLY38 |
| C | GLY39 |
| C | LEU40 |
| C | TRP41 |
| C | GLY50 |
| C | ARG51 |
| C | SER60 |
| C | ASN61 |
| C | SER62 |
| C | THR108 |
| C | VAL110 |
| C | CYS146 |
| C | THR147 |
| C | SER377 |
| C | ILE378 |
| C | NAP602 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | binding site for residue NAP C 602 |
| Chain | Residue |
| C | THR214 |
| C | THR215 |
| C | GLY216 |
| C | ARG223 |
| C | ARG280 |
| C | GLU281 |
| C | ALA328 |
| C | THR329 |
| C | GLY330 |
| C | TYR331 |
| C | FAD601 |
| C | TYR55 |
| C | VAL59 |
| C | ASN61 |
| C | PRO156 |
| C | SER159 |
| C | PHE160 |
| C | MET192 |
| C | GLY193 |
| C | ASN194 |
| C | SER195 |
| site_id | AC9 |
| Number of Residues | 25 |
| Details | binding site for residue FAD B 601 |
| Chain | Residue |
| B | GLY9 |
| B | GLY11 |
| B | VAL12 |
| B | SER13 |
| B | PHE31 |
| B | GLU32 |
| B | ARG33 |
| B | GLY38 |
| B | GLY39 |
| B | LEU40 |
| B | TRP41 |
| B | GLY50 |
| B | ARG51 |
| B | LEU54 |
| B | SER60 |
| B | ASN61 |
| B | SER62 |
| B | THR108 |
| B | VAL110 |
| B | CYS146 |
| B | THR147 |
| B | SER377 |
| B | ILE378 |
| B | NAP602 |
| B | HOH702 |
| site_id | AD1 |
| Number of Residues | 17 |
| Details | binding site for residue NAP B 602 |
| Chain | Residue |
| B | TYR55 |
| B | VAL59 |
| B | ASN61 |
| B | PHE160 |
| B | GLY191 |
| B | MET192 |
| B | GLY193 |
| B | ASN194 |
| B | SER195 |
| B | THR214 |
| B | THR215 |
| B | ARG280 |
| B | GLU281 |
| B | ALA328 |
| B | THR329 |
| B | GLY330 |
| B | FAD601 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue LMT B 604 |
| Chain | Residue |
| B | ASP456 |
| B | PRO457 |
| B | ARG458 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 605 |
| Chain | Residue |
| B | HIS178 |
| B | ILE181 |
| site_id | AD4 |
| Number of Residues | 25 |
| Details | binding site for residue FAD A 601 |
| Chain | Residue |
| A | GLY9 |
| A | GLY11 |
| A | VAL12 |
| A | SER13 |
| A | PHE31 |
| A | GLU32 |
| A | ARG33 |
| A | GLY38 |
| A | GLY39 |
| A | LEU40 |
| A | TRP41 |
| A | GLY50 |
| A | LEU54 |
| A | SER60 |
| A | ASN61 |
| A | SER62 |
| A | THR108 |
| A | VAL110 |
| A | CYS146 |
| A | THR147 |
| A | GLY148 |
| A | PHE337 |
| A | SER377 |
| A | ILE378 |
| A | NAP602 |
| site_id | AD5 |
| Number of Residues | 19 |
| Details | binding site for residue NAP A 602 |
| Chain | Residue |
| A | TYR55 |
| A | VAL59 |
| A | ASN61 |
| A | SER159 |
| A | PHE160 |
| A | MET192 |
| A | GLY193 |
| A | ASN194 |
| A | SER195 |
| A | ASP198 |
| A | THR214 |
| A | THR215 |
| A | ARG223 |
| A | ARG280 |
| A | GLU281 |
| A | ALA328 |
| A | THR329 |
| A | GLY330 |
| A | FAD601 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue LMT A 603 |
| Chain | Residue |
| A | ASP456 |
| A | PRO457 |
| A | ARG458 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 604 |
| Chain | Residue |
| A | THR44 |
| A | ARG51 |
| A | SER53 |
| A | LYS177 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue LMT A 606 |
| Chain | Residue |
| A | MET242 |
| A | ASN245 |
| A | SER246 |
| A | PHE420 |
| A | LYS446 |
| A | LEU449 |
Functional Information from PROSITE/UniProt
| site_id | PS00213 |
| Number of Residues | 13 |
| Details | LIPOCALIN Lipocalin signature. ERSd.DLGGLWRFT |
| Chain | Residue | Details |
| D | GLU32-THR44 |
