Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7AKS

Human ADP-ribosylserine hydrolase ARH3 mutant E41A in complex with H2B-S7-mar peptide

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000287	molecular_function	magnesium ion binding
AAA	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
AAA	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
AAA	0005515	molecular_function	protein binding
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005694	cellular_component	chromosome
AAA	0005737	cellular_component	cytoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0006281	biological_process	DNA repair
AAA	0006287	biological_process	base-excision repair, gap-filling
AAA	0016604	cellular_component	nuclear body
AAA	0016787	molecular_function	hydrolase activity
AAA	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
AAA	0046872	molecular_function	metal ion binding
AAA	0060546	biological_process	negative regulation of necroptotic process
AAA	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
AAA	0071451	biological_process	cellular response to superoxide
AAA	0090734	cellular_component	site of DNA damage
AAA	0140290	biological_process	peptidyl-serine ADP-deribosylation
AAA	0140292	molecular_function	ADP-ribosylserine hydrolase activity
CCC	0000287	molecular_function	magnesium ion binding
CCC	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
CCC	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
CCC	0005515	molecular_function	protein binding
CCC	0005634	cellular_component	nucleus
CCC	0005654	cellular_component	nucleoplasm
CCC	0005694	cellular_component	chromosome
CCC	0005737	cellular_component	cytoplasm
CCC	0005739	cellular_component	mitochondrion
CCC	0005759	cellular_component	mitochondrial matrix
CCC	0006281	biological_process	DNA repair
CCC	0006287	biological_process	base-excision repair, gap-filling
CCC	0016604	cellular_component	nuclear body
CCC	0016787	molecular_function	hydrolase activity
CCC	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
CCC	0046872	molecular_function	metal ion binding
CCC	0060546	biological_process	negative regulation of necroptotic process
CCC	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
CCC	0071451	biological_process	cellular response to superoxide
CCC	0090734	cellular_component	site of DNA damage
CCC	0140290	biological_process	peptidyl-serine ADP-deribosylation
CCC	0140292	molecular_function	ADP-ribosylserine hydrolase activity
EEE	0000287	molecular_function	magnesium ion binding
EEE	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
EEE	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
EEE	0005515	molecular_function	protein binding
EEE	0005634	cellular_component	nucleus
EEE	0005654	cellular_component	nucleoplasm
EEE	0005694	cellular_component	chromosome
EEE	0005737	cellular_component	cytoplasm
EEE	0005739	cellular_component	mitochondrion
EEE	0005759	cellular_component	mitochondrial matrix
EEE	0006281	biological_process	DNA repair
EEE	0006287	biological_process	base-excision repair, gap-filling
EEE	0016604	cellular_component	nuclear body
EEE	0016787	molecular_function	hydrolase activity
EEE	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
EEE	0046872	molecular_function	metal ion binding
EEE	0060546	biological_process	negative regulation of necroptotic process
EEE	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
EEE	0071451	biological_process	cellular response to superoxide
EEE	0090734	cellular_component	site of DNA damage
EEE	0140290	biological_process	peptidyl-serine ADP-deribosylation
EEE	0140292	molecular_function	ADP-ribosylserine hydrolase activity
GGG	0000287	molecular_function	magnesium ion binding
GGG	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
GGG	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
GGG	0005515	molecular_function	protein binding
GGG	0005634	cellular_component	nucleus
GGG	0005654	cellular_component	nucleoplasm
GGG	0005694	cellular_component	chromosome
GGG	0005737	cellular_component	cytoplasm
GGG	0005739	cellular_component	mitochondrion
GGG	0005759	cellular_component	mitochondrial matrix
GGG	0006281	biological_process	DNA repair
GGG	0006287	biological_process	base-excision repair, gap-filling
GGG	0016604	cellular_component	nuclear body
GGG	0016787	molecular_function	hydrolase activity
GGG	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
GGG	0046872	molecular_function	metal ion binding
GGG	0060546	biological_process	negative regulation of necroptotic process
GGG	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
GGG	0071451	biological_process	cellular response to superoxide
GGG	0090734	cellular_component	site of DNA damage
GGG	0140290	biological_process	peptidyl-serine ADP-deribosylation
GGG	0140292	molecular_function	ADP-ribosylserine hydrolase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21892188, ECO:0000269\|PubMed:29907568, ECO:0000269\|PubMed:30045870, ECO:0007744\|PDB:5ZQY, ECO:0007744\|PDB:6D36, ECO:0007744\|PDB:6D3A

Chain	Residue	Details
AAA	ALA41
CCC	ALA41
EEE	ALA41
GGG	ALA41

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21892188, ECO:0000269\|PubMed:29907568, ECO:0000269\|PubMed:30045870, ECO:0000269\|PubMed:33894202, ECO:0007744\|PDB:5ZQY, ECO:0007744\|PDB:6D36, ECO:0007744\|PDB:6D3A, ECO:0007744\|PDB:7L9I

Chain	Residue	Details
GGG	THR76
AAA	THR76
CCC	THR76
EEE	THR76

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:29907568, ECO:0000269\|PubMed:30045870, ECO:0007744\|PDB:5ZQY, ECO:0007744\|PDB:6D36, ECO:0007744\|PDB:6D3A

Chain	Residue	Details
CCC	LYS146
CCC	HIS182
EEE	ASP77
EEE	LYS146
EEE	HIS182
GGG	ASP77
GGG	LYS146
GGG	HIS182
AAA	ASP77
AAA	LYS146
AAA	HIS182
CCC	ASP77

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:34321462, ECO:0007744\|PDB:7ARW

Chain	Residue	Details
CCC	ASP78
EEE	ASP78
GGG	ASP78
AAA	ASP78

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:29907568, ECO:0007744\|PDB:6D36, ECO:0007744\|PDB:6D3A

Chain	Residue	Details
AAA	ILE271
CCC	LEU235
CCC	ILE271
EEE	LEU235
EEE	ILE271
GGG	LEU235
GGG	ILE271
AAA	LEU235

site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:21892188, ECO:0000269\|PubMed:29907568, ECO:0000269\|PubMed:30045870, ECO:0000269\|PubMed:33894202, ECO:0000269\|PubMed:34321462, ECO:0007744\|PDB:5ZQY, ECO:0007744\|PDB:6D36, ECO:0007744\|PDB:6D3A, ECO:0007744\|PDB:7AKR, ECO:0007744\|PDB:7AKS, ECO:0007744\|PDB:7ARW, ECO:0007744\|PDB:7L9H

Chain	Residue	Details
EEE	ASP314
EEE	ASP316
GGG	ASP314
GGG	ASP316
AAA	ASP314
AAA	ASP316
CCC	ASP314
CCC	ASP316

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21892188, ECO:0000269\|PubMed:29907568, ECO:0000269\|PubMed:30045870, ECO:0000269\|PubMed:33894202, ECO:0007744\|PDB:5ZQY, ECO:0007744\|PDB:6D36, ECO:0007744\|PDB:6D3A, ECO:0007744\|PDB:7L9H

Chain	Residue	Details
AAA	THR317
CCC	THR317
EEE	THR317
GGG	THR317

site_id	SWS_FT_FI8
Number of Residues	4
Details	SITE: Glutamate flap => ECO:0000269\|PubMed:29907568, ECO:0000269\|PubMed:30045870

Chain	Residue	Details
AAA	ALA41
CCC	ALA41
EEE	ALA41
GGG	ALA41

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
AAA	THR64
CCC	THR64
EEE	THR64
GGG	THR64

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)