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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7AJK

Crystal structure of CRYI-B Rac1 complex

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
BBB0000166molecular_functionnucleotide binding
BBB0000242cellular_componentpericentriolar material
BBB0001764biological_processneuron migration
BBB0001891cellular_componentphagocytic cup
BBB0001934biological_processpositive regulation of protein phosphorylation
BBB0003376biological_processsphingosine-1-phosphate receptor signaling pathway
BBB0003924molecular_functionGTPase activity
BBB0003925molecular_functionG protein activity
BBB0005515molecular_functionprotein binding
BBB0005525molecular_functionGTP binding
BBB0005634cellular_componentnucleus
BBB0005654cellular_componentnucleoplasm
BBB0005730cellular_componentnucleolus
BBB0005737cellular_componentcytoplasm
BBB0005789cellular_componentendoplasmic reticulum membrane
BBB0005802cellular_componenttrans-Golgi network
BBB0005829cellular_componentcytosol
BBB0005856cellular_componentcytoskeleton
BBB0005884cellular_componentactin filament
BBB0005886cellular_componentplasma membrane
BBB0005925cellular_componentfocal adhesion
BBB0005938cellular_componentcell cortex
BBB0006911biological_processphagocytosis, engulfment
BBB0006954biological_processinflammatory response
BBB0007015biological_processactin filament organization
BBB0007155biological_processcell adhesion
BBB0007160biological_processcell-matrix adhesion
BBB0007163biological_processestablishment or maintenance of cell polarity
BBB0007167biological_processenzyme-linked receptor protein signaling pathway
BBB0007264biological_processsmall GTPase-mediated signal transduction
BBB0008045biological_processmotor neuron axon guidance
BBB0008360biological_processregulation of cell shape
BBB0009611biological_processresponse to wounding
BBB0009653biological_processanatomical structure morphogenesis
BBB0010310biological_processregulation of hydrogen peroxide metabolic process
BBB0010591biological_processregulation of lamellipodium assembly
BBB0010592biological_processpositive regulation of lamellipodium assembly
BBB0010595biological_processpositive regulation of endothelial cell migration
BBB0010762biological_processregulation of fibroblast migration
BBB0010764biological_processnegative regulation of fibroblast migration
BBB0010810biological_processregulation of cell-substrate adhesion
BBB0016020cellular_componentmembrane
BBB0016477biological_processcell migration
BBB0016601biological_processRac protein signal transduction
BBB0016787molecular_functionhydrolase activity
BBB0019899molecular_functionenzyme binding
BBB0019901molecular_functionprotein kinase binding
BBB0030027cellular_componentlamellipodium
BBB0030031biological_processcell projection assembly
BBB0030032biological_processlamellipodium assembly
BBB0030036biological_processactin cytoskeleton organization
BBB0030041biological_processactin filament polymerization
BBB0030334biological_processregulation of cell migration
BBB0030425cellular_componentdendrite
BBB0030667cellular_componentsecretory granule membrane
BBB0030672cellular_componentsynaptic vesicle membrane
BBB0030742molecular_functionGTP-dependent protein binding
BBB0030865biological_processcortical cytoskeleton organization
BBB0030900biological_processforebrain development
BBB0031410cellular_componentcytoplasmic vesicle
BBB0031529biological_processruffle organization
BBB0031901cellular_componentearly endosome membrane
BBB0031996molecular_functionthioesterase binding
BBB0032496biological_processresponse to lipopolysaccharide
BBB0032587cellular_componentruffle membrane
BBB0032707biological_processnegative regulation of interleukin-23 production
BBB0032956biological_processregulation of actin cytoskeleton organization
BBB0034446biological_processsubstrate adhesion-dependent cell spreading
BBB0035025biological_processpositive regulation of Rho protein signal transduction
BBB0035556biological_processintracellular signal transduction
BBB0035567biological_processnon-canonical Wnt signaling pathway
BBB0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
BBB0036464cellular_componentcytoplasmic ribonucleoprotein granule
BBB0042470cellular_componentmelanosome
BBB0042554biological_processsuperoxide anion generation
BBB0042734cellular_componentpresynaptic membrane
BBB0042995cellular_componentcell projection
BBB0043020cellular_componentNADPH oxidase complex
BBB0043652biological_processengulfment of apoptotic cell
BBB0044877molecular_functionprotein-containing complex binding
BBB0045202cellular_componentsynapse
BBB0045211cellular_componentpostsynaptic membrane
BBB0045428biological_processregulation of nitric oxide biosynthetic process
BBB0045730biological_processrespiratory burst
BBB0046425biological_processregulation of receptor signaling pathway via JAK-STAT
BBB0048012biological_processhepatocyte growth factor receptor signaling pathway
BBB0048261biological_processnegative regulation of receptor-mediated endocytosis
BBB0048812biological_processneuron projection morphogenesis
BBB0048870biological_processcell motility
BBB0051022molecular_functionRho GDP-dissociation inhibitor binding
BBB0051492biological_processregulation of stress fiber assembly
BBB0051496biological_processpositive regulation of stress fiber assembly
BBB0051668biological_processlocalization within membrane
BBB0051894biological_processpositive regulation of focal adhesion assembly
BBB0055038cellular_componentrecycling endosome membrane
BBB0060071biological_processWnt signaling pathway, planar cell polarity pathway
BBB0060091cellular_componentkinocilium
BBB0060263biological_processregulation of respiratory burst
BBB0060326biological_processcell chemotaxis
BBB0061344biological_processregulation of cell adhesion involved in heart morphogenesis
BBB0070062cellular_componentextracellular exosome
BBB0071526biological_processsemaphorin-plexin signaling pathway
BBB0090023biological_processpositive regulation of neutrophil chemotaxis
BBB0097178biological_processruffle assembly
BBB0098794cellular_componentpostsynapse
BBB0098978cellular_componentglutamatergic synapse
BBB0101003cellular_componentficolin-1-rich granule membrane
BBB0150052biological_processregulation of postsynapse assembly
BBB1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
BBB1900029biological_processpositive regulation of ruffle assembly
BBB1900242biological_processregulation of synaptic vesicle endocytosis
BBB1902622biological_processregulation of neutrophil migration
BBB1903348biological_processpositive regulation of bicellular tight junction assembly
BBB1904948biological_processmidbrain dopaminergic neuron differentiation
BBB2000386biological_processpositive regulation of ovarian follicle development
CCC0001916biological_processpositive regulation of T cell mediated cytotoxicity
CCC0005515molecular_functionprotein binding
CCC0005576cellular_componentextracellular region
CCC0005739cellular_componentmitochondrion
CCC0005929cellular_componentcilium
CCC0016020cellular_componentmembrane
CCC0023030molecular_functionMHC class Ib protein binding, via antigen binding groove
CCC0030334biological_processregulation of cell migration
CCC0030833biological_processregulation of actin filament polymerization
CCC0030837biological_processnegative regulation of actin filament polymerization
CCC0031093cellular_componentplatelet alpha granule lumen
CCC0031267molecular_functionsmall GTPase binding
CCC0032729biological_processpositive regulation of type II interferon production
CCC0050870biological_processpositive regulation of T cell activation
CCC0050920biological_processregulation of chemotaxis
CCC0051058biological_processnegative regulation of small GTPase mediated signal transduction
CCC0070062cellular_componentextracellular exosome
CCC0071219biological_processcellular response to molecule of bacterial origin
CCC0090140biological_processregulation of mitochondrial fission
CCC2000114biological_processregulation of establishment of cell polarity
CCC2000568biological_processpositive regulation of memory T cell activation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WEJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WEJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"18093184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23512198","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"31285585","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2025-12-10

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