7AI0

Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0005634	cellular_component	nucleus
AAA	0042802	molecular_function	identical protein binding
AAA	0043066	biological_process	negative regulation of apoptotic process
AAA	0051726	biological_process	regulation of cell cycle
AAA	0061630	molecular_function	ubiquitin protein ligase activity
BBB	0000151	cellular_component	ubiquitin ligase complex
BBB	0000209	biological_process	protein polyubiquitination
BBB	0004842	molecular_function	ubiquitin-protein transferase activity
BBB	0005515	molecular_function	protein binding
BBB	0005524	molecular_function	ATP binding
BBB	0005634	cellular_component	nucleus
BBB	0005654	cellular_component	nucleoplasm
BBB	0005829	cellular_component	cytosol
BBB	0006511	biological_process	ubiquitin-dependent protein catabolic process
BBB	0016567	biological_process	protein ubiquitination
BBB	0016740	molecular_function	transferase activity
BBB	0019787	molecular_function	ubiquitin-like protein transferase activity
BBB	0031371	cellular_component	ubiquitin conjugating enzyme complex
BBB	0031625	molecular_function	ubiquitin protein ligase binding
BBB	0032991	cellular_component	protein-containing complex
BBB	0036211	biological_process	protein modification process
BBB	0051865	biological_process	protein autoubiquitination
BBB	0061630	molecular_function	ubiquitin protein ligase activity
BBB	0061631	molecular_function	ubiquitin conjugating enzyme activity
BBB	0070062	cellular_component	extracellular exosome
BBB	0070936	biological_process	protein K48-linked ubiquitination
DDD	0005634	cellular_component	nucleus
DDD	0042802	molecular_function	identical protein binding
DDD	0043066	biological_process	negative regulation of apoptotic process
DDD	0051726	biological_process	regulation of cell cycle
DDD	0061630	molecular_function	ubiquitin protein ligase activity
EEE	0000151	cellular_component	ubiquitin ligase complex
EEE	0000209	biological_process	protein polyubiquitination
EEE	0004842	molecular_function	ubiquitin-protein transferase activity
EEE	0005515	molecular_function	protein binding
EEE	0005524	molecular_function	ATP binding
EEE	0005634	cellular_component	nucleus
EEE	0005654	cellular_component	nucleoplasm
EEE	0005829	cellular_component	cytosol
EEE	0006511	biological_process	ubiquitin-dependent protein catabolic process
EEE	0016567	biological_process	protein ubiquitination
EEE	0016740	molecular_function	transferase activity
EEE	0019787	molecular_function	ubiquitin-like protein transferase activity
EEE	0031371	cellular_component	ubiquitin conjugating enzyme complex
EEE	0031625	molecular_function	ubiquitin protein ligase binding
EEE	0032991	cellular_component	protein-containing complex
EEE	0036211	biological_process	protein modification process
EEE	0051865	biological_process	protein autoubiquitination
EEE	0061630	molecular_function	ubiquitin protein ligase activity
EEE	0061631	molecular_function	ubiquitin conjugating enzyme activity
EEE	0070062	cellular_component	extracellular exosome
EEE	0070936	biological_process	protein K48-linked ubiquitination

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
CCC	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
CCC	GLY-1
FFF	GLY-1

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
CCC	GLY-1
DDD	THR419
FFF	GLY-1

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by ATM => ECO:0000269|PubMed:19816404

Chain	Residue	Details
AAA	SER425
AAA	SER429
DDD	SER425
DDD	SER429

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