7AI0

Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0005634	cellular_component	nucleus
AAA	0042802	molecular_function	identical protein binding
AAA	0043066	biological_process	negative regulation of apoptotic process
AAA	0051726	biological_process	regulation of cell cycle
AAA	0061630	molecular_function	ubiquitin protein ligase activity
BBB	0000166	molecular_function	nucleotide binding
BBB	0000209	biological_process	protein polyubiquitination
BBB	0004842	molecular_function	ubiquitin-protein transferase activity
BBB	0005515	molecular_function	protein binding
BBB	0005524	molecular_function	ATP binding
BBB	0005634	cellular_component	nucleus
BBB	0005654	cellular_component	nucleoplasm
BBB	0005829	cellular_component	cytosol
BBB	0006511	biological_process	ubiquitin-dependent protein catabolic process
BBB	0016567	biological_process	protein ubiquitination
BBB	0016740	molecular_function	transferase activity
BBB	0032991	cellular_component	protein-containing complex
BBB	0036211	biological_process	protein modification process
BBB	0051865	biological_process	protein autoubiquitination
BBB	0061630	molecular_function	ubiquitin protein ligase activity
BBB	0061631	molecular_function	ubiquitin conjugating enzyme activity
BBB	0070062	cellular_component	extracellular exosome
BBB	0070936	biological_process	protein K48-linked ubiquitination
DDD	0005634	cellular_component	nucleus
DDD	0042802	molecular_function	identical protein binding
DDD	0043066	biological_process	negative regulation of apoptotic process
DDD	0051726	biological_process	regulation of cell cycle
DDD	0061630	molecular_function	ubiquitin protein ligase activity
EEE	0000166	molecular_function	nucleotide binding
EEE	0000209	biological_process	protein polyubiquitination
EEE	0004842	molecular_function	ubiquitin-protein transferase activity
EEE	0005515	molecular_function	protein binding
EEE	0005524	molecular_function	ATP binding
EEE	0005634	cellular_component	nucleus
EEE	0005654	cellular_component	nucleoplasm
EEE	0005829	cellular_component	cytosol
EEE	0006511	biological_process	ubiquitin-dependent protein catabolic process
EEE	0016567	biological_process	protein ubiquitination
EEE	0016740	molecular_function	transferase activity
EEE	0032991	cellular_component	protein-containing complex
EEE	0036211	biological_process	protein modification process
EEE	0051865	biological_process	protein autoubiquitination
EEE	0061630	molecular_function	ubiquitin protein ligase activity
EEE	0061631	molecular_function	ubiquitin conjugating enzyme activity
EEE	0070062	cellular_component	extracellular exosome
EEE	0070936	biological_process	protein K48-linked ubiquitination

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
CCC	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	82
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Motif: {"description":"Nucleolar localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	150
Details	Domain: {"description":"Ubiquitin-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---