7ADO

Cryo-EM structure of human ER membrane protein complex in lipid nanodiscs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0072546	cellular_component	EMC complex
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0032977	molecular_function	membrane insertase activity
B	0042406	cellular_component	extrinsic component of endoplasmic reticulum membrane
B	0045050	biological_process	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
B	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
B	0072546	cellular_component	EMC complex
C	0005515	molecular_function	protein binding
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0016020	cellular_component	membrane
C	0032977	molecular_function	membrane insertase activity
C	0045050	biological_process	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
C	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
C	0072546	cellular_component	EMC complex
D	0005515	molecular_function	protein binding
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006915	biological_process	apoptotic process
D	0016020	cellular_component	membrane
D	0032977	molecular_function	membrane insertase activity
D	0045050	biological_process	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
D	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
D	0072546	cellular_component	EMC complex
E	0000139	cellular_component	Golgi membrane
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005769	cellular_component	early endosome
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005794	cellular_component	Golgi apparatus
E	0005886	cellular_component	plasma membrane
E	0006824	biological_process	cobalt ion transport
E	0015087	molecular_function	cobalt ion transmembrane transporter activity
E	0015093	molecular_function	ferrous iron transmembrane transporter activity
E	0015095	molecular_function	magnesium ion transmembrane transporter activity
E	0015693	biological_process	magnesium ion transport
E	0016020	cellular_component	membrane
E	0022857	molecular_function	transmembrane transporter activity
E	0031901	cellular_component	early endosome membrane
E	0032977	molecular_function	membrane insertase activity
E	0034755	biological_process	iron ion transmembrane transport
E	0045050	biological_process	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
E	0055085	biological_process	transmembrane transport
E	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
E	0072546	cellular_component	EMC complex
E	1903830	biological_process	magnesium ion transmembrane transport
F	0000045	biological_process	autophagosome assembly
F	0005515	molecular_function	protein binding
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0016020	cellular_component	membrane
F	0032977	molecular_function	membrane insertase activity
F	0045050	biological_process	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
F	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
F	0072546	cellular_component	EMC complex
F	1903349	cellular_component	omegasome membrane
G	0030246	molecular_function	carbohydrate binding
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0016020	cellular_component	membrane
H	0032977	molecular_function	membrane insertase activity
H	0045050	biological_process	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
H	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
H	0072546	cellular_component	EMC complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	164
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"32439656","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	26
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32439656","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32439656","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WW7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32439656","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WW7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	33
Details	Repeat: {"description":"TPR 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	33
Details	Repeat: {"description":"TPR 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	33
Details	Repeat: {"description":"TPR 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	65
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"32439656","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	34
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"32459176","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32439656","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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