7ABV

Structure of the S1-cleaved mouse Notch1 Negative Regulatory Region (NRR)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007219	biological_process	Notch signaling pathway
A	0007275	biological_process	multicellular organism development
A	0016020	cellular_component	membrane
A	0030154	biological_process	cell differentiation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00525

Chain	Residue	Details
A	ASP1457
A	ASN1460
A	ASP1475
A	ASP1478

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by furin-like protease => ECO:0000269|PubMed:9653148

Chain	Residue	Details
A	ARG1654

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by ADAM17 => ECO:0000269|PubMed:10882062, ECO:0000269|PubMed:10882063

Chain	Residue	Details
A	ALA1710

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN1489
A	ASN1587

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