7AAJ

Human porphobilinogen deaminase in complex with cofactor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004418	molecular_function	hydroxymethylbilane synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006779	biological_process	porphyrin-containing compound biosynthetic process
A	0006782	biological_process	protoporphyrinogen IX biosynthetic process
A	0006783	biological_process	heme biosynthetic process
A	0006784	biological_process	heme A biosynthetic process
A	0006785	biological_process	heme B biosynthetic process
A	0016740	molecular_function	transferase activity
A	0018160	biological_process	peptidyl-pyrromethane cofactor linkage
A	0033014	biological_process	tetrapyrrole biosynthetic process
A	0048034	biological_process	heme O biosynthetic process
B	0004418	molecular_function	hydroxymethylbilane synthase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006779	biological_process	porphyrin-containing compound biosynthetic process
B	0006782	biological_process	protoporphyrinogen IX biosynthetic process
B	0006783	biological_process	heme biosynthetic process
B	0006784	biological_process	heme A biosynthetic process
B	0006785	biological_process	heme B biosynthetic process
B	0016740	molecular_function	transferase activity
B	0018160	biological_process	peptidyl-pyrromethane cofactor linkage
B	0033014	biological_process	tetrapyrrole biosynthetic process
B	0048034	biological_process	heme O biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00533
Number of Residues	17
Details	PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaFlrhLeGGCsVPVA

Chain	Residue	Details
B	GLU250-ALA266

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
B	SER2
A	SER2

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site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER15
B	SER69
B	SER147
A	SER15
A	SER69
A	SER147

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P22907

Chain	Residue	Details
B	LYS74
A	LYS74

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: S-(dipyrrolylmethanemethyl)cysteine => ECO:0000269|PubMed:18936296

Chain	Residue	Details
B	CYS261
A	CYS261

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