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7A20

Azobenzene-Based Inhibitors for Tryptophan Synthase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000162biological_processL-tryptophan biosynthetic process
A0003824molecular_functioncatalytic activity
A0004834molecular_functiontryptophan synthase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006568biological_processL-tryptophan metabolic process
A0008652biological_processamino acid biosynthetic process
A0009073biological_processaromatic amino acid family biosynthetic process
A0016829molecular_functionlyase activity
A0042802molecular_functionidentical protein binding
B0000162biological_processL-tryptophan biosynthetic process
B0003824molecular_functioncatalytic activity
B0004834molecular_functiontryptophan synthase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006568biological_processL-tryptophan metabolic process
B0008652biological_processamino acid biosynthetic process
B0009073biological_processaromatic amino acid family biosynthetic process
B0016829molecular_functionlyase activity
B0042802molecular_functionidentical protein binding
C0000162biological_processL-tryptophan biosynthetic process
C0003824molecular_functioncatalytic activity
C0004834molecular_functiontryptophan synthase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006568biological_processL-tryptophan metabolic process
C0008652biological_processamino acid biosynthetic process
C0009073biological_processaromatic amino acid family biosynthetic process
C0016829molecular_functionlyase activity
C0042802molecular_functionidentical protein binding
D0000162biological_processL-tryptophan biosynthetic process
D0003824molecular_functioncatalytic activity
D0004834molecular_functiontryptophan synthase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006568biological_processL-tryptophan metabolic process
D0008652biological_processamino acid biosynthetic process
D0009073biological_processaromatic amino acid family biosynthetic process
D0016829molecular_functionlyase activity
D0042802molecular_functionidentical protein binding
Functional Information from PROSITE/UniProt
site_idPS00167
Number of Residues14
DetailsTRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGvPFSDPLADG
ChainResidueDetails
ALEU48-GLY61

site_idPS00168
Number of Residues15
DetailsTRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LlHgGAHKtNqvLgQ
ChainResidueDetails
ALEU353-GLN367

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"N6-(pyridoxal phosphate)lysine"}
ChainResidueDetails

Catalytic Information from CSA
site_idMCSA1
Number of Residues3
DetailsM-CSA 383
ChainResidueDetails
AGLU49hydrogen bond acceptor, proton acceptor, proton donor
AASP60hydrogen bond acceptor
ATYR175hydrogen bond donor

site_idMCSA2
Number of Residues3
DetailsM-CSA 383
ChainResidueDetails
CGLU49hydrogen bond acceptor, proton acceptor, proton donor
CASP60hydrogen bond acceptor
CTYR175hydrogen bond donor

site_idMCSA3
Number of Residues3
DetailsM-CSA 383
ChainResidueDetails
BLYS87electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor
BGLU109
BSER377hydrogen bond donor

site_idMCSA4
Number of Residues3
DetailsM-CSA 383
ChainResidueDetails
DLYS87electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor
DGLU109
DSER377hydrogen bond donor

239149

PDB entries from 2025-07-23

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