7A20

Azobenzene-Based Inhibitors for Tryptophan Synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000162	biological_process	L-tryptophan biosynthetic process
A	0003824	molecular_function	catalytic activity
A	0004834	molecular_function	tryptophan synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006568	biological_process	L-tryptophan metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0016829	molecular_function	lyase activity
A	0042802	molecular_function	identical protein binding
B	0000162	biological_process	L-tryptophan biosynthetic process
B	0003824	molecular_function	catalytic activity
B	0004834	molecular_function	tryptophan synthase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006568	biological_process	L-tryptophan metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0016829	molecular_function	lyase activity
B	0042802	molecular_function	identical protein binding
C	0000162	biological_process	L-tryptophan biosynthetic process
C	0003824	molecular_function	catalytic activity
C	0004834	molecular_function	tryptophan synthase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006568	biological_process	L-tryptophan metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0016829	molecular_function	lyase activity
C	0042802	molecular_function	identical protein binding
D	0000162	biological_process	L-tryptophan biosynthetic process
D	0003824	molecular_function	catalytic activity
D	0004834	molecular_function	tryptophan synthase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006568	biological_process	L-tryptophan metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0016829	molecular_function	lyase activity
D	0042802	molecular_function	identical protein binding

Functional Information from PROSITE/UniProt

site_id	PS00167
Number of Residues	14
Details	TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGvPFSDPLADG

Chain	Residue	Details
A	LEU48-GLY61

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site_id	PS00168
Number of Residues	15
Details	TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LlHgGAHKtNqvLgQ

Chain	Residue	Details
A	LEU353-GLN367

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine"}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 383

Chain	Residue	Details
A	GLU49	hydrogen bond acceptor, proton acceptor, proton donor
A	ASP60	hydrogen bond acceptor
A	TYR175	hydrogen bond donor

---

site_id	MCSA2
Number of Residues	3
Details	M-CSA 383

Chain	Residue	Details
C	GLU49	hydrogen bond acceptor, proton acceptor, proton donor
C	ASP60	hydrogen bond acceptor
C	TYR175	hydrogen bond donor

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site_id	MCSA3
Number of Residues	3
Details	M-CSA 383

Chain	Residue	Details
B	LYS87	electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor
B	GLU109
B	SER377	hydrogen bond donor

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site_id	MCSA4
Number of Residues	3
Details	M-CSA 383

Chain	Residue	Details
D	LYS87	electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor
D	GLU109
D	SER377	hydrogen bond donor

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