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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6ZZR

The Crystal Structure of human LDHA from Biortus.

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AAA0003824molecular_functioncatalytic activity
AAA0004457molecular_functionlactate dehydrogenase activity
AAA0004459molecular_functionL-lactate dehydrogenase (NAD+) activity
AAA0005515molecular_functionprotein binding
AAA0005634cellular_componentnucleus
AAA0005737cellular_componentcytoplasm
AAA0005739cellular_componentmitochondrion
AAA0005829cellular_componentcytosol
AAA0006089biological_processlactate metabolic process
AAA0006096biological_processglycolytic process
AAA0016020cellular_componentmembrane
AAA0016491molecular_functionoxidoreductase activity
AAA0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
AAA0019752biological_processcarboxylic acid metabolic process
AAA0035686cellular_componentsperm fibrous sheath
AAA0042802molecular_functionidentical protein binding
AAA0042867biological_processpyruvate catabolic process
AAA0045296molecular_functioncadherin binding
AAA0070062cellular_componentextracellular exosome
BBB0003824molecular_functioncatalytic activity
BBB0004457molecular_functionlactate dehydrogenase activity
BBB0004459molecular_functionL-lactate dehydrogenase (NAD+) activity
BBB0005515molecular_functionprotein binding
BBB0005634cellular_componentnucleus
BBB0005737cellular_componentcytoplasm
BBB0005739cellular_componentmitochondrion
BBB0005829cellular_componentcytosol
BBB0006089biological_processlactate metabolic process
BBB0006096biological_processglycolytic process
BBB0016020cellular_componentmembrane
BBB0016491molecular_functionoxidoreductase activity
BBB0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
BBB0019752biological_processcarboxylic acid metabolic process
BBB0035686cellular_componentsperm fibrous sheath
BBB0042802molecular_functionidentical protein binding
BBB0042867biological_processpyruvate catabolic process
BBB0045296molecular_functioncadherin binding
BBB0070062cellular_componentextracellular exosome
CCC0003824molecular_functioncatalytic activity
CCC0004457molecular_functionlactate dehydrogenase activity
CCC0004459molecular_functionL-lactate dehydrogenase (NAD+) activity
CCC0005515molecular_functionprotein binding
CCC0005634cellular_componentnucleus
CCC0005737cellular_componentcytoplasm
CCC0005739cellular_componentmitochondrion
CCC0005829cellular_componentcytosol
CCC0006089biological_processlactate metabolic process
CCC0006096biological_processglycolytic process
CCC0016020cellular_componentmembrane
CCC0016491molecular_functionoxidoreductase activity
CCC0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
CCC0019752biological_processcarboxylic acid metabolic process
CCC0035686cellular_componentsperm fibrous sheath
CCC0042802molecular_functionidentical protein binding
CCC0042867biological_processpyruvate catabolic process
CCC0045296molecular_functioncadherin binding
CCC0070062cellular_componentextracellular exosome
DDD0003824molecular_functioncatalytic activity
DDD0004457molecular_functionlactate dehydrogenase activity
DDD0004459molecular_functionL-lactate dehydrogenase (NAD+) activity
DDD0005515molecular_functionprotein binding
DDD0005634cellular_componentnucleus
DDD0005737cellular_componentcytoplasm
DDD0005739cellular_componentmitochondrion
DDD0005829cellular_componentcytosol
DDD0006089biological_processlactate metabolic process
DDD0006096biological_processglycolytic process
DDD0016020cellular_componentmembrane
DDD0016491molecular_functionoxidoreductase activity
DDD0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
DDD0019752biological_processcarboxylic acid metabolic process
DDD0035686cellular_componentsperm fibrous sheath
DDD0042802molecular_functionidentical protein binding
DDD0042867biological_processpyruvate catabolic process
DDD0045296molecular_functioncadherin binding
DDD0070062cellular_componentextracellular exosome
EEE0003824molecular_functioncatalytic activity
EEE0004457molecular_functionlactate dehydrogenase activity
EEE0004459molecular_functionL-lactate dehydrogenase (NAD+) activity
EEE0005515molecular_functionprotein binding
EEE0005634cellular_componentnucleus
EEE0005737cellular_componentcytoplasm
EEE0005739cellular_componentmitochondrion
EEE0005829cellular_componentcytosol
EEE0006089biological_processlactate metabolic process
EEE0006096biological_processglycolytic process
EEE0016020cellular_componentmembrane
EEE0016491molecular_functionoxidoreductase activity
EEE0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
EEE0019752biological_processcarboxylic acid metabolic process
EEE0035686cellular_componentsperm fibrous sheath
EEE0042802molecular_functionidentical protein binding
EEE0042867biological_processpyruvate catabolic process
EEE0045296molecular_functioncadherin binding
EEE0070062cellular_componentextracellular exosome
FFF0003824molecular_functioncatalytic activity
FFF0004457molecular_functionlactate dehydrogenase activity
FFF0004459molecular_functionL-lactate dehydrogenase (NAD+) activity
FFF0005515molecular_functionprotein binding
FFF0005634cellular_componentnucleus
FFF0005737cellular_componentcytoplasm
FFF0005739cellular_componentmitochondrion
FFF0005829cellular_componentcytosol
FFF0006089biological_processlactate metabolic process
FFF0006096biological_processglycolytic process
FFF0016020cellular_componentmembrane
FFF0016491molecular_functionoxidoreductase activity
FFF0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
FFF0019752biological_processcarboxylic acid metabolic process
FFF0035686cellular_componentsperm fibrous sheath
FFF0042802molecular_functionidentical protein binding
FFF0042867biological_processpyruvate catabolic process
FFF0045296molecular_functioncadherin binding
FFF0070062cellular_componentextracellular exosome
GGG0003824molecular_functioncatalytic activity
GGG0004457molecular_functionlactate dehydrogenase activity
GGG0004459molecular_functionL-lactate dehydrogenase (NAD+) activity
GGG0005515molecular_functionprotein binding
GGG0005634cellular_componentnucleus
GGG0005737cellular_componentcytoplasm
GGG0005739cellular_componentmitochondrion
GGG0005829cellular_componentcytosol
GGG0006089biological_processlactate metabolic process
GGG0006096biological_processglycolytic process
GGG0016020cellular_componentmembrane
GGG0016491molecular_functionoxidoreductase activity
GGG0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GGG0019752biological_processcarboxylic acid metabolic process
GGG0035686cellular_componentsperm fibrous sheath
GGG0042802molecular_functionidentical protein binding
GGG0042867biological_processpyruvate catabolic process
GGG0045296molecular_functioncadherin binding
GGG0070062cellular_componentextracellular exosome
HHH0003824molecular_functioncatalytic activity
HHH0004457molecular_functionlactate dehydrogenase activity
HHH0004459molecular_functionL-lactate dehydrogenase (NAD+) activity
HHH0005515molecular_functionprotein binding
HHH0005634cellular_componentnucleus
HHH0005737cellular_componentcytoplasm
HHH0005739cellular_componentmitochondrion
HHH0005829cellular_componentcytosol
HHH0006089biological_processlactate metabolic process
HHH0006096biological_processglycolytic process
HHH0016020cellular_componentmembrane
HHH0016491molecular_functionoxidoreductase activity
HHH0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
HHH0019752biological_processcarboxylic acid metabolic process
HHH0035686cellular_componentsperm fibrous sheath
HHH0042802molecular_functionidentical protein binding
HHH0042867biological_processpyruvate catabolic process
HHH0045296molecular_functioncadherin binding
HHH0070062cellular_componentextracellular exosome
Functional Information from PROSITE/UniProt
site_idPS00064
Number of Residues7
DetailsL_LDH L-lactate dehydrogenase active site. LGEHGDS
ChainResidueDetails
AAALEU190-SER196
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues232
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11276087","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues32
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues24
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P06151","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues24
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues24
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P06151","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P06151","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues16
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P04642","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues16
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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