6ZZR

The Crystal Structure of human LDHA from Biortus.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0003824	molecular_function	catalytic activity
AAA	0004459	molecular_function	L-lactate dehydrogenase activity
AAA	0005515	molecular_function	protein binding
AAA	0005634	cellular_component	nucleus
AAA	0005737	cellular_component	cytoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005829	cellular_component	cytosol
AAA	0006089	biological_process	lactate metabolic process
AAA	0006090	biological_process	pyruvate metabolic process
AAA	0006096	biological_process	glycolytic process
AAA	0016020	cellular_component	membrane
AAA	0016491	molecular_function	oxidoreductase activity
AAA	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
AAA	0019752	biological_process	carboxylic acid metabolic process
AAA	0042802	molecular_function	identical protein binding
AAA	0045296	molecular_function	cadherin binding
AAA	0070062	cellular_component	extracellular exosome
AAA	1990204	cellular_component	oxidoreductase complex
BBB	0003824	molecular_function	catalytic activity
BBB	0004459	molecular_function	L-lactate dehydrogenase activity
BBB	0005515	molecular_function	protein binding
BBB	0005634	cellular_component	nucleus
BBB	0005737	cellular_component	cytoplasm
BBB	0005739	cellular_component	mitochondrion
BBB	0005829	cellular_component	cytosol
BBB	0006089	biological_process	lactate metabolic process
BBB	0006090	biological_process	pyruvate metabolic process
BBB	0006096	biological_process	glycolytic process
BBB	0016020	cellular_component	membrane
BBB	0016491	molecular_function	oxidoreductase activity
BBB	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
BBB	0019752	biological_process	carboxylic acid metabolic process
BBB	0042802	molecular_function	identical protein binding
BBB	0045296	molecular_function	cadherin binding
BBB	0070062	cellular_component	extracellular exosome
BBB	1990204	cellular_component	oxidoreductase complex
CCC	0003824	molecular_function	catalytic activity
CCC	0004459	molecular_function	L-lactate dehydrogenase activity
CCC	0005515	molecular_function	protein binding
CCC	0005634	cellular_component	nucleus
CCC	0005737	cellular_component	cytoplasm
CCC	0005739	cellular_component	mitochondrion
CCC	0005829	cellular_component	cytosol
CCC	0006089	biological_process	lactate metabolic process
CCC	0006090	biological_process	pyruvate metabolic process
CCC	0006096	biological_process	glycolytic process
CCC	0016020	cellular_component	membrane
CCC	0016491	molecular_function	oxidoreductase activity
CCC	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
CCC	0019752	biological_process	carboxylic acid metabolic process
CCC	0042802	molecular_function	identical protein binding
CCC	0045296	molecular_function	cadherin binding
CCC	0070062	cellular_component	extracellular exosome
CCC	1990204	cellular_component	oxidoreductase complex
DDD	0003824	molecular_function	catalytic activity
DDD	0004459	molecular_function	L-lactate dehydrogenase activity
DDD	0005515	molecular_function	protein binding
DDD	0005634	cellular_component	nucleus
DDD	0005737	cellular_component	cytoplasm
DDD	0005739	cellular_component	mitochondrion
DDD	0005829	cellular_component	cytosol
DDD	0006089	biological_process	lactate metabolic process
DDD	0006090	biological_process	pyruvate metabolic process
DDD	0006096	biological_process	glycolytic process
DDD	0016020	cellular_component	membrane
DDD	0016491	molecular_function	oxidoreductase activity
DDD	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
DDD	0019752	biological_process	carboxylic acid metabolic process
DDD	0042802	molecular_function	identical protein binding
DDD	0045296	molecular_function	cadherin binding
DDD	0070062	cellular_component	extracellular exosome
DDD	1990204	cellular_component	oxidoreductase complex
EEE	0003824	molecular_function	catalytic activity
EEE	0004459	molecular_function	L-lactate dehydrogenase activity
EEE	0005515	molecular_function	protein binding
EEE	0005634	cellular_component	nucleus
EEE	0005737	cellular_component	cytoplasm
EEE	0005739	cellular_component	mitochondrion
EEE	0005829	cellular_component	cytosol
EEE	0006089	biological_process	lactate metabolic process
EEE	0006090	biological_process	pyruvate metabolic process
EEE	0006096	biological_process	glycolytic process
EEE	0016020	cellular_component	membrane
EEE	0016491	molecular_function	oxidoreductase activity
EEE	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
EEE	0019752	biological_process	carboxylic acid metabolic process
EEE	0042802	molecular_function	identical protein binding
EEE	0045296	molecular_function	cadherin binding
EEE	0070062	cellular_component	extracellular exosome
EEE	1990204	cellular_component	oxidoreductase complex
FFF	0003824	molecular_function	catalytic activity
FFF	0004459	molecular_function	L-lactate dehydrogenase activity
FFF	0005515	molecular_function	protein binding
FFF	0005634	cellular_component	nucleus
FFF	0005737	cellular_component	cytoplasm
FFF	0005739	cellular_component	mitochondrion
FFF	0005829	cellular_component	cytosol
FFF	0006089	biological_process	lactate metabolic process
FFF	0006090	biological_process	pyruvate metabolic process
FFF	0006096	biological_process	glycolytic process
FFF	0016020	cellular_component	membrane
FFF	0016491	molecular_function	oxidoreductase activity
FFF	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
FFF	0019752	biological_process	carboxylic acid metabolic process
FFF	0042802	molecular_function	identical protein binding
FFF	0045296	molecular_function	cadherin binding
FFF	0070062	cellular_component	extracellular exosome
FFF	1990204	cellular_component	oxidoreductase complex
GGG	0003824	molecular_function	catalytic activity
GGG	0004459	molecular_function	L-lactate dehydrogenase activity
GGG	0005515	molecular_function	protein binding
GGG	0005634	cellular_component	nucleus
GGG	0005737	cellular_component	cytoplasm
GGG	0005739	cellular_component	mitochondrion
GGG	0005829	cellular_component	cytosol
GGG	0006089	biological_process	lactate metabolic process
GGG	0006090	biological_process	pyruvate metabolic process
GGG	0006096	biological_process	glycolytic process
GGG	0016020	cellular_component	membrane
GGG	0016491	molecular_function	oxidoreductase activity
GGG	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GGG	0019752	biological_process	carboxylic acid metabolic process
GGG	0042802	molecular_function	identical protein binding
GGG	0045296	molecular_function	cadherin binding
GGG	0070062	cellular_component	extracellular exosome
GGG	1990204	cellular_component	oxidoreductase complex
HHH	0003824	molecular_function	catalytic activity
HHH	0004459	molecular_function	L-lactate dehydrogenase activity
HHH	0005515	molecular_function	protein binding
HHH	0005634	cellular_component	nucleus
HHH	0005737	cellular_component	cytoplasm
HHH	0005739	cellular_component	mitochondrion
HHH	0005829	cellular_component	cytosol
HHH	0006089	biological_process	lactate metabolic process
HHH	0006090	biological_process	pyruvate metabolic process
HHH	0006096	biological_process	glycolytic process
HHH	0016020	cellular_component	membrane
HHH	0016491	molecular_function	oxidoreductase activity
HHH	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
HHH	0019752	biological_process	carboxylic acid metabolic process
HHH	0042802	molecular_function	identical protein binding
HHH	0045296	molecular_function	cadherin binding
HHH	0070062	cellular_component	extracellular exosome
HHH	1990204	cellular_component	oxidoreductase complex

Functional Information from PROSITE/UniProt

site_id	PS00064
Number of Residues	7
Details	L_LDH L-lactate dehydrogenase active site. LGEHGDS

Chain	Residue	Details
AAA	LEU190-SER196

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
AAA	HIS193
BBB	HIS193
CCC	HIS193
DDD	HIS193
EEE	HIS193
FFF	HIS193
GGG	HIS193
HHH	HIS193

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:11276087

Chain	Residue	Details
AAA	GLY29
EEE	ARG99
FFF	GLY29
FFF	ARG99
GGG	GLY29
GGG	ARG99
HHH	GLY29
HHH	ARG99
AAA	ARG99
BBB	GLY29
BBB	ARG99
CCC	GLY29
CCC	ARG99
DDD	GLY29
DDD	ARG99
EEE	GLY29

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING:

Chain	Residue	Details
AAA	ARG106
CCC	ASN138
CCC	ARG169
CCC	THR248
DDD	ARG106
DDD	ASN138
DDD	ARG169
DDD	THR248
EEE	ARG106
EEE	ASN138
EEE	ARG169
AAA	ASN138
EEE	THR248
FFF	ARG106
FFF	ASN138
FFF	ARG169
FFF	THR248
GGG	ARG106
GGG	ASN138
GGG	ARG169
GGG	THR248
HHH	ARG106
AAA	ARG169
HHH	ASN138
HHH	ARG169
HHH	THR248
AAA	THR248
BBB	ARG106
BBB	ASN138
BBB	ARG169
BBB	THR248
CCC	ARG106

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N-acetylalanine => ECO:0000269|Ref.10, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895

Chain	Residue	Details
AAA	ALA2
BBB	ALA2
CCC	ALA2
DDD	ALA2
EEE	ALA2
FFF	ALA2
GGG	ALA2
HHH	ALA2

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06151

Chain	Residue	Details
AAA	LYS5
DDD	LYS5
DDD	LYS118
DDD	LYS318
EEE	LYS5
EEE	LYS118
EEE	LYS318
FFF	LYS5
FFF	LYS118
FFF	LYS318
GGG	LYS5
AAA	LYS118
GGG	LYS118
GGG	LYS318
HHH	LYS5
HHH	LYS118
HHH	LYS318
AAA	LYS318
BBB	LYS5
BBB	LYS118
BBB	LYS318
CCC	LYS5
CCC	LYS118
CCC	LYS318

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
AAA	TYR10
BBB	TYR10
CCC	TYR10
DDD	TYR10
EEE	TYR10
FFF	TYR10
GGG	TYR10
HHH	TYR10

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
AAA	LYS14
DDD	LYS14
DDD	LYS81
DDD	LYS126
EEE	LYS14
EEE	LYS81
EEE	LYS126
FFF	LYS14
FFF	LYS81
FFF	LYS126
GGG	LYS14
AAA	LYS81
GGG	LYS81
GGG	LYS126
HHH	LYS14
HHH	LYS81
HHH	LYS126
AAA	LYS126
BBB	LYS14
BBB	LYS81
BBB	LYS126
CCC	LYS14
CCC	LYS81
CCC	LYS126

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
AAA	THR18
BBB	THR18
CCC	THR18
DDD	THR18
EEE	THR18
FFF	THR18
GGG	THR18
HHH	THR18

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
AAA	LYS57
BBB	LYS57
CCC	LYS57
DDD	LYS57
EEE	LYS57
FFF	LYS57
GGG	LYS57
HHH	LYS57

---

site_id	SWS_FT_FI10
Number of Residues	24
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P06151

Chain	Residue	Details
AAA	LYS224
DDD	LYS224
DDD	LYS232
DDD	LYS243
EEE	LYS224
EEE	LYS232
EEE	LYS243
FFF	LYS224
FFF	LYS232
FFF	LYS243
GGG	LYS224
AAA	LYS232
GGG	LYS232
GGG	LYS243
HHH	LYS224
HHH	LYS232
HHH	LYS243
AAA	LYS243
BBB	LYS224
BBB	LYS232
BBB	LYS243
CCC	LYS224
CCC	LYS232
CCC	LYS243

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P06151

Chain	Residue	Details
AAA	TYR239
BBB	TYR239
CCC	TYR239
DDD	TYR239
EEE	TYR239
FFF	TYR239
GGG	TYR239
HHH	TYR239

---

site_id	SWS_FT_FI12
Number of Residues	16
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P04642

Chain	Residue	Details
AAA	THR309
EEE	THR322
FFF	THR309
FFF	THR322
GGG	THR309
GGG	THR322
HHH	THR309
HHH	THR322
AAA	THR322
BBB	THR309
BBB	THR322
CCC	THR309
CCC	THR322
DDD	THR309
DDD	THR322
EEE	THR309

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
AAA	SER310
BBB	SER310
CCC	SER310
DDD	SER310
EEE	SER310
FFF	SER310
GGG	SER310
HHH	SER310

---

site_id	SWS_FT_FI14
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
AAA	LYS57
FFF	LYS57
GGG	LYS57
HHH	LYS57
BBB	LYS57
CCC	LYS57
DDD	LYS57
EEE	LYS57

---