6ZZ6
Cryo-EM structure of S.cerevisiae cohesin-Scc2-DNA complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0007062 | biological_process | sister chromatid cohesion |
| A | 0008278 | cellular_component | cohesin complex |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0007062 | biological_process | sister chromatid cohesion |
| C | 0008278 | cellular_component | cohesin complex |
| D | 0000775 | cellular_component | chromosome, centromeric region |
| D | 0000785 | cellular_component | chromatin |
| D | 0000972 | biological_process | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery |
| D | 0003682 | molecular_function | chromatin binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005729 | cellular_component | 2-micrometer circle DNA |
| D | 0005829 | cellular_component | cytosol |
| D | 0006302 | biological_process | double-strand break repair |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0007064 | biological_process | mitotic sister chromatid cohesion |
| D | 0007076 | biological_process | mitotic chromosome condensation |
| D | 0010468 | biological_process | regulation of gene expression |
| D | 0032116 | cellular_component | SMC loading complex |
| D | 0034087 | biological_process | establishment of mitotic sister chromatid cohesion |
| D | 0043515 | molecular_function | kinetochore binding |
| D | 0043565 | molecular_function | sequence-specific DNA binding |
| D | 0061775 | molecular_function | cohesin loader activity |
| D | 0070058 | biological_process | tRNA gene clustering |
| D | 0070550 | biological_process | rDNA chromatin condensation |
| D | 0071168 | biological_process | protein localization to chromatin |
| D | 0071169 | biological_process | establishment of protein localization to chromatin |
| D | 0090694 | cellular_component | Scc2-Scc4 cohesin loading complex |
| D | 0140588 | biological_process | chromatin looping |
| D | 1990414 | biological_process | replication-born double-strand break repair via sister chromatid exchange |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGEKTVAALALLF |
| Chain | Residue | Details |
| A | LEU1129-PHE1143 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18614053","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"26354421","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"26354421","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; in mutant scc2-8A","evidences":[{"source":"PubMed","id":"26354421","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; in mutant scc2-8A","evidences":[{"source":"PubMed","id":"26354421","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
