6ZX3

OMPD-domain of human UMPS in complex with 6-thiocarboxamido-UMP at 1.15 Angstroms resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue QRZ A 501

Chain	Residue
A	SER257
A	MET371
A	SER372
A	PRO417
A	GLN430
A	TYR432
A	GLY450
A	ARG451
A	HOH630
A	HOH633
A	HOH661
A	ASP259
A	LYS281
A	HIS283
A	ASP312
A	LYS314
A	ASP317
A	ILE318
A	THR321

---

site_id	AC2
Number of Residues	4
Details	binding site for residue GOL A 502

Chain	Residue
A	THR374
A	GLY429
A	HOH609
A	HOH698

---

site_id	AC3
Number of Residues	8
Details	binding site for residue PRO A 503

Chain	Residue
A	GLY228
A	GLU232
A	LEU421
A	HOH606
A	HOH749
A	HOH858
A	HOH879
A	HOH926

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 504

Chain	Residue
A	SER348
A	LYS352
A	HIS393
A	HOH669
A	HOH690

---

Functional Information from PROSITE/UniProt

site_id	PS00156
Number of Residues	14
Details	OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFeDrKfaDIGnTV

Chain	Residue	Details
A	ILE309-VAL322

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"For OMPdecase activity","evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QCH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18184586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QCL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---