6ZMU
Crystal structure of the germline-specific thioredoxin protein Deadhead (Thioredoxin-1) from Drospohila melanogaster, P43212
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0005829 | cellular_component | cytosol |
| A | 0007143 | biological_process | female meiotic nuclear division |
| A | 0015035 | molecular_function | protein-disulfide reductase activity |
| A | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| A | 0035041 | biological_process | sperm DNA decondensation |
| A | 0060322 | biological_process | head development |
| B | 0005634 | cellular_component | nucleus |
| B | 0005829 | cellular_component | cytosol |
| B | 0007143 | biological_process | female meiotic nuclear division |
| B | 0015035 | molecular_function | protein-disulfide reductase activity |
| B | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| B | 0035041 | biological_process | sperm DNA decondensation |
| B | 0060322 | biological_process | head development |
| C | 0005634 | cellular_component | nucleus |
| C | 0005829 | cellular_component | cytosol |
| C | 0007143 | biological_process | female meiotic nuclear division |
| C | 0015035 | molecular_function | protein-disulfide reductase activity |
| C | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| C | 0035041 | biological_process | sperm DNA decondensation |
| C | 0060322 | biological_process | head development |
| D | 0005634 | cellular_component | nucleus |
| D | 0005829 | cellular_component | cytosol |
| D | 0007143 | biological_process | female meiotic nuclear division |
| D | 0015035 | molecular_function | protein-disulfide reductase activity |
| D | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| D | 0035041 | biological_process | sperm DNA decondensation |
| D | 0060322 | biological_process | head development |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | HOH313 |
| C | HOH202 |
| D | ARG81 |
| D | ARG84 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | THR6 |
| A | ASN8 |
| A | LYS12 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 203 |
| Chain | Residue |
| A | ARG68 |
| A | TYR69 |
| A | TYR10 |
| A | HIS11 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 204 |
| Chain | Residue |
| A | ALA87 |
| A | SER88 |
| A | HOH301 |
| B | ARG68 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 A 205 |
| Chain | Residue |
| A | ARG13 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 206 |
| Chain | Residue |
| A | MET1 |
| A | ALA2 |
| A | SER3 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 201 |
| Chain | Residue |
| A | PHE89 |
| A | LYS96 |
| B | MET7 |
| B | TYR10 |
| B | HIS11 |
| B | LEU65 |
| B | ARG68 |
| B | HOH303 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 202 |
| Chain | Residue |
| B | LYS70 |
| B | ARG72 |
| B | ARG84 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 203 |
| Chain | Residue |
| A | HIS95 |
| B | ARG85 |
| B | LEU86 |
| B | ALA87 |
| B | SER88 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 204 |
| Chain | Residue |
| A | GLY32 |
| A | LYS103 |
| B | LYS70 |
| B | ARG72 |
| B | HOH301 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 205 |
| Chain | Residue |
| A | HOH316 |
| B | ASP60 |
| B | GLU63 |
| C | ASP60 |
| C | GLU63 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 201 |
| Chain | Residue |
| D | PHE89 |
| D | ALA90 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 202 |
| Chain | Residue |
| D | MET7 |
| D | HIS11 |
| D | GLU64 |
| D | ARG68 |
| D | SO4203 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 203 |
| Chain | Residue |
| A | ASP19 |
| A | GLN82 |
| D | TYR10 |
| D | HIS11 |
| D | ARG68 |
| D | TYR69 |
| D | SO4202 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 D 204 |
| Chain | Residue |
| D | ARG13 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 205 |
| Chain | Residue |
| B | LYS35 |
| D | ARG5 |
| D | THR6 |
| D | ASN8 |
| D | ASP9 |
Functional Information from PROSITE/UniProt
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. VLdFYatWCGPCKeMestV |
| Chain | Residue | Details |
| A | VAL23-VAL41 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Nucleophile |
| Chain | Residue | Details |
| A | CYS31 | |
| A | CYS34 | |
| B | CYS31 | |
| B | CYS34 | |
| C | CYS31 | |
| C | CYS34 | |
| D | CYS31 | |
| D | CYS34 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Deprotonates C-terminal active site Cys => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP25 | |
| B | ASP25 | |
| C | ASP25 | |
| D | ASP25 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | SITE: Contributes to redox potential value |
| Chain | Residue | Details |
| A | GLY32 | |
| A | PRO33 | |
| B | GLY32 | |
| B | PRO33 | |
| C | GLY32 | |
| C | PRO33 | |
| D | GLY32 | |
| D | PRO33 |
