6ZKA

Membrane domain of open complex I during turnover

Functional Information from GO Data

Chain	GOid	namespace	contents
4	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
4	0048038	molecular_function	quinone binding
4	0051287	molecular_function	NAD binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0070469	cellular_component	respirasome
A	1902600	biological_process	proton transmembrane transport
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0031966	cellular_component	mitochondrial membrane
H	0032981	biological_process	mitochondrial respiratory chain complex I assembly
H	0070469	cellular_component	respirasome
H	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
J	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0032981	biological_process	mitochondrial respiratory chain complex I assembly
J	0070469	cellular_component	respirasome
J	1902600	biological_process	proton transmembrane transport
k	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
k	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0045271	cellular_component	respiratory chain complex I
K	0070469	cellular_component	respirasome
K	1902600	biological_process	proton transmembrane transport
L	0003954	molecular_function	NADH dehydrogenase activity
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
L	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0015990	biological_process	electron transport coupled proton transport
L	0032981	biological_process	mitochondrial respiratory chain complex I assembly
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0070469	cellular_component	respirasome
m	0005743	cellular_component	mitochondrial inner membrane
m	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0070469	cellular_component	respirasome
M	1902600	biological_process	proton transmembrane transport
n	0005739	cellular_component	mitochondrion
n	0022900	biological_process	electron transport chain
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
N	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N	0070469	cellular_component	respirasome
N	0072593	biological_process	reactive oxygen species metabolic process
N	1902600	biological_process	proton transmembrane transport
o	0005737	cellular_component	cytoplasm
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
o	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
o	0032981	biological_process	mitochondrial respiratory chain complex I assembly
o	0070469	cellular_component	respirasome
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
p	0016020	cellular_component	membrane
r	0005743	cellular_component	mitochondrial inner membrane
r	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0016020	cellular_component	membrane
s	0005739	cellular_component	mitochondrion
t	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
u	0005743	cellular_component	mitochondrial inner membrane
u	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
v	0005739	cellular_component	mitochondrion
v	0005743	cellular_component	mitochondrial inner membrane
v	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
v	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
v	0032981	biological_process	mitochondrial respiratory chain complex I assembly
v	0070469	cellular_component	respirasome
V	0032981	biological_process	mitochondrial respiratory chain complex I assembly
x	0005739	cellular_component	mitochondrion
x	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
X	0000035	molecular_function	acyl binding
X	0000036	molecular_function	acyl carrier activity
X	0005739	cellular_component	mitochondrion
X	0005747	cellular_component	obsolete mitochondrial respiratory chain complex I
X	0006633	biological_process	fatty acid biosynthetic process
y	0005739	cellular_component	mitochondrion
Y	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue PC1 A 201

Chain	Residue
A	ASN83
A	THR86
J	THR151

---

site_id	AC2
Number of Residues	8
Details	binding site for residue DCQ H 501

Chain	Residue
H	PHE224
H	MET225
H	THR21
H	ARG25
H	ASP51
H	LEU55
H	PHE56
H	PHE220

---

site_id	AC3
Number of Residues	20
Details	binding site for residue 3PE H 502

Chain	Residue
A	LEU3
A	LEU7
A	PHE11
H	LEU77
H	MET98
H	ASN99
H	PHE104
J	ILE34
J	GLY38
J	GLY42
J	LEU45
J	ASN46
J	SER50
J	LEU54
J	PHE57
q	PHE139
q	ILE140
q	TRP141
q	THR143
z	ALA39

---

site_id	AC4
Number of Residues	13
Details	binding site for residue PC1 H 503

Chain	Residue
H	TRP179
H	PRO180
H	ALA182
H	PHE186
H	ILE187
H	PHE280
H	HIS287
H	LEU288
H	ASN292
H	PHE293
H	LEU296
m	LYS14
m	GLU15

---

site_id	AC5
Number of Residues	10
Details	binding site for residue 3PE K 101

Chain	Residue
J	SER21
J	LYS23
J	VAL88
J	THR92
K	THR17
K	MET21
K	TYR22
K	ARG23
L	LYS585
V	3PE201

---

site_id	AC6
Number of Residues	17
Details	binding site for residue 3PE L 701

Chain	Residue
4	TRP10
4	GLN13
4	TYR14
4	MET19
4	TYR20
L	PRO563
L	SER567
L	GLN570
L	MET571
M	ASN144
M	LEU147
M	PHE151
M	TYR152
M	PC1502
N	ILE284
N	LEU288
N	TYR291

---

site_id	AC7
Number of Residues	14
Details	binding site for residue 3PE L 702

Chain	Residue
L	ASP163
L	THR166
L	GLN170
L	TYR174
L	THR221
L	TYR529
L	HIS534
L	PRO538
L	ASN541
L	HOH848
L	HOH862
v	ASN87
v	ARG88
v	HOH215

---

site_id	AC8
Number of Residues	17
Details	binding site for residue PC1 L 703

Chain	Residue
r	HIS88
r	LYS92
w	PC1801
L	TRP66
L	HIS67
L	TRP68
L	SER77
L	LEU78
L	ASN136
L	PHE138
L	ILE142
L	CDL704
L	HOH817
W	CDL201
r	ILE80
r	TYR83
r	TYR84

---

site_id	AC9
Number of Residues	29
Details	binding site for residue CDL L 704

Chain	Residue
L	ASN23
L	PHE24
L	GLN116
L	LYS119
L	TYR120
L	THR127
L	ILE142
L	MET150
L	PC1703
L	HOH850
L	HOH853
L	HOH860
L	HOH898
M	PRO353
M	LEU354
M	ALA357
M	TRP358
M	LEU360
M	LEU361
M	LEU364
M	LEU369
M	PRO370
M	PRO371
M	SER372
M	LEU445
W	LEU22
W	ILE29
W	CDL201
w	PC1801

---

site_id	AD1
Number of Residues	3
Details	binding site for residue 3PE L 705

Chain	Residue
L	MET383
L	PHE498
n	VAL63

---

site_id	AD2
Number of Residues	9
Details	binding site for residue 3PE M 501

Chain	Residue
L	ILE561
M	ASN188
M	TRP190
M	GLY211
M	MET257
M	PHE261
M	LEU264
M	HOH612
V	LEU87

---

site_id	AD3
Number of Residues	13
Details	binding site for residue PC1 M 502

Chain	Residue
L	3PE701
M	ALA155
M	TYR166
M	SER191
M	MET195
M	LEU197
M	MET201
M	VAL205
M	HOH711
N	ILE276
N	ILE277
V	GLU130
V	TRP132

---

site_id	AD4
Number of Residues	28
Details	binding site for residue CDL M 503

Chain	Residue
M	TRP16
M	ALA90
M	ARG91
M	LEU94
M	MET98
M	LEU101
M	VAL127
M	ARG135
M	HOH628
M	HOH667
M	HOH669
N	PRO238
N	ILE239
N	ILE242
N	LEU257
N	THR334
N	MET335
k	LYS303
k	TYR304
k	HOH605
o	GLY35
o	PHE36
o	TYR39
o	LEU43
o	ILE44
o	ALA47
o	VAL53
o	LEU54

---

site_id	AD5
Number of Residues	13
Details	binding site for residue 3PE N 401

Chain	Residue
N	LYS46
N	SER125
N	LEU128
N	ILE129
N	THR132
N	TRP133
N	THR217
N	MET220
N	ARG322
N	THR324
N	MET329
N	HOH588
l	PHE3

---

site_id	AD6
Number of Residues	5
Details	binding site for residue 3PE V 201

Chain	Residue
K	3PE101
V	VAL40
V	PRO45
V	PHE48
V	GLY51

---

site_id	AD7
Number of Residues	5
Details	binding site for residue 3PE V 202

Chain	Residue
V	TRP9
V	LEU123
V	GLY127
V	TRP132
V	CDL203

---

site_id	AD8
Number of Residues	20
Details	binding site for residue CDL V 203

Chain	Residue
L	THR576
L	SER579
L	GLN580
L	THR594
L	SER598
L	PHE604
N	PHE113
N	LEU157
V	TYR8
V	ALA24
V	SER31
V	VAL35
V	TYR38
V	SER39
V	LEU42
V	LYS43
V	TYR58
V	PHE69
V	3PE202
V	CDL204

---

site_id	AD9
Number of Residues	13
Details	binding site for residue CDL V 204

Chain	Residue
L	THR560
L	ILE561
L	LEU562
L	THR565
L	ALA569
L	LYS572
V	GLY108
V	ILE109
V	ALA112
V	ALA113
V	TYR116
V	THR120
V	CDL203

---

site_id	AE1
Number of Residues	20
Details	binding site for residue CDL W 201

Chain	Residue
L	LEU12
L	ASN65
L	PC1703
L	CDL704
W	GLY33
W	ILE40
W	THR41
W	ASN44
W	GLU49
W	HIS69
Z	VAL47
Z	ARG48
Z	ILE51
r	TRP79
r	TYR83
r	HIS88
w	THR75
w	ALA78
w	TYR79
w	PC1801

---

site_id	AE2
Number of Residues	10
Details	binding site for residue ZMP X 101

Chain	Residue
X	ASP43
X	SER44
t	HIS11
t	GLN12
t	ARG46
t	PHE47
t	HIS50
t	LYS51
t	ALA59
t	ALA66

---

site_id	AE3
Number of Residues	24
Details	binding site for residue CDL Y 201

Chain	Residue
M	LEU2
M	ILE5
M	MET9
M	MET10
M	SER53
M	THR55
M	LEU104
M	PHE105
M	MET121
M	HOH666
N	PRO256
N	PRO338
Y	PHE168
Y	TRP169
Y	THR170
Y	MET171
Y	HOH301
o	PRO29
o	ARG30
o	TYR33
o	PHE36
y	PHE22
y	ASN30
y	LYS33

---

site_id	AE4
Number of Residues	12
Details	binding site for residue AMP k 501

Chain	Residue
k	ILE31
k	SEP36
k	GLU53
k	PHE82
k	TYR83
k	GLN97
k	LEU100
k	ARG104
k	ARG126
k	PHE134
k	MET138
k	TYR198

---

site_id	AE5
Number of Residues	9
Details	binding site for residue 3PE m 101

Chain	Residue
A	PHE96
A	ALA99
A	TRP106
H	PRO295
H	MET302
m	GLU15
m	LEU18
m	SER21
m	PHE22

---

site_id	AE6
Number of Residues	7
Details	binding site for residue 3PE o 501

Chain	Residue
N	ILE345
l	HOH207
o	LEU11
o	PHE13
o	ARG78
o	HOH611
o	HOH633

---

site_id	AE7
Number of Residues	16
Details	binding site for residue CDL o 502

Chain	Residue
N	THR324
N	LEU325
N	THR328
N	HOH526
o	ASP45
o	ARG60
o	LEU63
o	TYR64
o	SER67
o	PHE68
o	HOH606
o	HOH634
x	LYS16
x	LEU19
x	THR20
x	THR23

---

site_id	AE8
Number of Residues	8
Details	binding site for residue 3PE p 201

Chain	Residue
L	TRP557
V	TYR107
V	GLY108
p	PRO81
p	ASN82
p	THR83
p	SER86
p	GLY89

---

site_id	AE9
Number of Residues	5
Details	binding site for residue MYR s 201

Chain	Residue
L	TYR485
s	GLY1
s	ALA2
s	LEU4
v	THR124

---

site_id	AF1
Number of Residues	16
Details	binding site for residue PC1 w 801

Chain	Residue
L	TRP66
L	PC1703
L	CDL704
M	PRO64
M	LEU68
M	TRP71
M	LEU446
M	ILE454
M	HOH686
W	CDL201
w	VAL69
w	SER74
w	VAL77
w	ALA78
w	TYR79
w	HOH902

---

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
X	ASP39-MET54

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
X	ASP64-ILE76

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
4	LEU83-LYS94

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDAIKLFiKE

Chain	Residue	Details
H	GLY44-GLU59

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
H	PRO197-GLY210

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
N	PRO3-SER23
N	ASP274-MET294
N	LEU325-ILE345
L	MET366-LEU386
L	LEU413-GLY433
L	LEU457-ILE477
L	TYR485-SER505
L	GLY582-LEU602
N	HIS25-MET45
N	SER67-MET87
N	MET96-PRO116
N	ILE122-LEU142
N	ILE145-GLY165
N	ILE178-PRO198
N	MET200-MET220
N	ALA237-LEU257

---