6ZIR
CRYSTAL STRUCTURE OF NRAS (C118S) IN COMPLEX WITH GDP AND COMPOUND 18
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001938 | biological_process | positive regulation of endothelial cell proliferation |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007265 | biological_process | Ras protein signal transduction |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0046579 | biological_process | positive regulation of Ras protein signal transduction |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070821 | cellular_component | tertiary granule membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 201 |
| Chain | Residue |
| A | SER17 |
| A | GDP203 |
| A | HOH308 |
| A | HOH323 |
| A | HOH327 |
| A | HOH329 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | HOH490 |
| A | HOH490 |
| A | HOH490 |
| A | THR124 |
| A | GLN129 |
| A | HOH342 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | binding site for residue GDP A 203 |
| Chain | Residue |
| A | GLY13 |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| A | ASP30 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | MG201 |
| A | HOH308 |
| A | HOH327 |
| A | HOH329 |
| A | HOH346 |
| A | HOH361 |
| A | HOH392 |
| A | HOH398 |
| A | HOH403 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue EZZ A 204 |
| Chain | Residue |
| A | TYR4 |
| A | ASP47 |
| A | GLY48 |
| A | GLU49 |
| A | PRO140 |
| A | PHE141 |
| A | ILE142 |
| A | THR158 |
| A | ARG164 |
| A | HOH344 |
| A | HOH367 |
| A | HOH401 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue EZZ A 205 |
| Chain | Residue |
| A | LEU6 |
| A | VAL7 |
| A | GLU37 |
| A | GLU37 |
| A | SER39 |
| A | ASP54 |
| A | LEU56 |
| A | GLN70 |
| A | TYR71 |
| A | THR74 |
| A | GLY75 |
| A | HOH304 |
| A | HOH304 |
| A | HOH397 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of the human NRAS GTPase bound with GDP.","authors":["Nedyalkova L.","Tong Y.","Tempel W.","Shen L.","Loppnau P.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Weigelt J.","Bochkarev A.","Park H."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30712867","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
