6ZIP
Crystal Structure of Two-Domain Laccase mutant R240A from Streptomyces griseoflavus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| B | 0005507 | molecular_function | copper ion binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| C | 0005507 | molecular_function | copper ion binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| D | 0005507 | molecular_function | copper ion binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| E | 0005507 | molecular_function | copper ion binding |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| F | 0005507 | molecular_function | copper ion binding |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| G | 0005507 | molecular_function | copper ion binding |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| H | 0005507 | molecular_function | copper ion binding |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| I | 0005507 | molecular_function | copper ion binding |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| J | 0005507 | molecular_function | copper ion binding |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| K | 0005507 | molecular_function | copper ion binding |
| K | 0016491 | molecular_function | oxidoreductase activity |
| K | 0046872 | molecular_function | metal ion binding |
| K | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| L | 0005507 | molecular_function | copper ion binding |
| L | 0016491 | molecular_function | oxidoreductase activity |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CU A 401 |
| Chain | Residue |
| A | HIS232 |
| A | CYS289 |
| A | HIS294 |
| A | MET299 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CU A 402 |
| Chain | Residue |
| A | HIS237 |
| A | HIS288 |
| C | HIS159 |
| C | OXY406 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CU A 403 |
| Chain | Residue |
| A | HIS237 |
| C | HIS103 |
| C | HIS105 |
| C | CU401 |
| C | OXY406 |
| A | HIS235 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CU A 404 |
| Chain | Residue |
| A | HIS105 |
| A | HIS157 |
| A | HOH571 |
| B | HIS290 |
| B | CU403 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CU B 401 |
| Chain | Residue |
| B | HIS232 |
| B | CYS289 |
| B | HIS294 |
| B | MET299 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CU B 402 |
| Chain | Residue |
| A | HIS159 |
| A | HOH571 |
| B | HIS237 |
| B | HIS288 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue CU B 403 |
| Chain | Residue |
| A | HIS103 |
| A | HIS105 |
| A | CU404 |
| A | HOH571 |
| B | HIS235 |
| B | HIS237 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue CU B 404 |
| Chain | Residue |
| B | HIS103 |
| B | HIS105 |
| B | HIS157 |
| C | HIS290 |
| C | CU404 |
| C | HOH540 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 405 |
| Chain | Residue |
| B | ARG50 |
| B | VAL52 |
| B | GLU81 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue CU C 401 |
| Chain | Residue |
| A | HIS290 |
| A | CU403 |
| C | HIS105 |
| C | HIS157 |
| C | OXY406 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue CU C 402 |
| Chain | Residue |
| C | HIS232 |
| C | CYS289 |
| C | HIS294 |
| C | MET299 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue CU C 403 |
| Chain | Residue |
| B | HIS159 |
| C | HIS237 |
| C | HIS288 |
| C | HOH540 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue CU C 404 |
| Chain | Residue |
| B | HIS103 |
| B | HIS105 |
| B | CU404 |
| C | HIS235 |
| C | HIS237 |
| C | HOH540 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 405 |
| Chain | Residue |
| C | ARG50 |
| C | VAL52 |
| C | LEU79 |
| C | GLU81 |
| site_id | AD6 |
| Number of Residues | 11 |
| Details | binding site for residue OXY C 406 |
| Chain | Residue |
| A | HIS235 |
| A | HIS237 |
| A | HIS290 |
| A | CU402 |
| A | CU403 |
| C | HIS103 |
| C | HIS105 |
| C | HIS157 |
| C | HIS159 |
| C | CU401 |
| C | HOH524 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue CU D 401 |
| Chain | Residue |
| D | HIS232 |
| D | CYS289 |
| D | HIS294 |
| D | MET299 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue CU D 402 |
| Chain | Residue |
| D | HIS237 |
| D | HIS288 |
| F | HIS159 |
| F | HOH558 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue CU D 403 |
| Chain | Residue |
| D | HIS235 |
| D | HIS237 |
| F | HIS103 |
| F | HIS105 |
| F | CU401 |
| F | HOH558 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue CU D 404 |
| Chain | Residue |
| D | HIS105 |
| D | HIS157 |
| D | CU405 |
| E | HIS290 |
| E | HOH565 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue CU D 405 |
| Chain | Residue |
| E | HIS237 |
| E | HOH565 |
| D | HIS103 |
| D | HIS105 |
| D | CU404 |
| E | HIS235 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue CU E 401 |
| Chain | Residue |
| E | HIS232 |
| E | CYS289 |
| E | HIS294 |
| E | MET299 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue CU E 402 |
| Chain | Residue |
| D | HIS159 |
| E | HIS237 |
| E | HIS288 |
| E | HOH565 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue CU E 403 |
| Chain | Residue |
| E | HIS105 |
| E | HIS157 |
| E | PER404 |
| F | HIS290 |
| F | CU404 |
| site_id | AE6 |
| Number of Residues | 12 |
| Details | binding site for residue PER E 404 |
| Chain | Residue |
| E | HIS103 |
| E | HIS105 |
| E | HIS157 |
| E | HIS159 |
| E | CU403 |
| E | HOH553 |
| F | HIS235 |
| F | HIS237 |
| F | HIS288 |
| F | HIS290 |
| F | CU403 |
| F | CU404 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL E 405 |
| Chain | Residue |
| E | ARG50 |
| E | LEU79 |
| E | ILE80 |
| E | GLU81 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue CU F 401 |
| Chain | Residue |
| D | HIS290 |
| D | CU403 |
| F | HIS105 |
| F | HIS157 |
| F | HOH558 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue CU F 402 |
| Chain | Residue |
| F | HIS232 |
| F | CYS289 |
| F | HIS294 |
| F | MET299 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue CU F 403 |
| Chain | Residue |
| E | HIS159 |
| E | PER404 |
| F | HIS237 |
| F | HIS288 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue CU F 404 |
| Chain | Residue |
| E | HIS103 |
| E | HIS105 |
| E | CU403 |
| E | PER404 |
| F | HIS235 |
| F | HIS237 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue CU G 401 |
| Chain | Residue |
| G | HIS232 |
| G | CYS289 |
| G | HIS294 |
| G | MET299 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue CU G 402 |
| Chain | Residue |
| G | HIS237 |
| G | HIS288 |
| G | HOH543 |
| I | HIS159 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue CU G 403 |
| Chain | Residue |
| G | HIS105 |
| G | HIS157 |
| H | HIS290 |
| H | CU403 |
| H | OXY405 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue CU H 401 |
| Chain | Residue |
| H | HIS232 |
| H | CYS289 |
| H | HIS294 |
| H | MET299 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue CU H 402 |
| Chain | Residue |
| G | HIS159 |
| H | HIS237 |
| H | HIS288 |
| H | OXY405 |
| site_id | AF8 |
| Number of Residues | 6 |
| Details | binding site for residue CU H 403 |
| Chain | Residue |
| G | HIS103 |
| G | CU403 |
| G | HOH517 |
| H | HIS235 |
| H | HIS237 |
| H | OXY405 |
| site_id | AF9 |
| Number of Residues | 5 |
| Details | binding site for residue CU H 404 |
| Chain | Residue |
| H | HIS105 |
| H | HIS157 |
| I | HIS290 |
| I | CU405 |
| I | HOH543 |
| site_id | AG1 |
| Number of Residues | 11 |
| Details | binding site for residue OXY H 405 |
| Chain | Residue |
| G | HIS103 |
| G | HIS157 |
| G | HIS159 |
| G | CU403 |
| H | HIS235 |
| H | HIS237 |
| H | HIS288 |
| H | HIS290 |
| H | CU402 |
| H | CU403 |
| H | HOH506 |
| site_id | AG2 |
| Number of Residues | 5 |
| Details | binding site for residue CU I 401 |
| Chain | Residue |
| G | HIS290 |
| G | HOH543 |
| I | HIS105 |
| I | HIS157 |
| I | CU402 |
| site_id | AG3 |
| Number of Residues | 6 |
| Details | binding site for residue CU I 402 |
| Chain | Residue |
| G | HIS235 |
| G | HIS237 |
| G | HOH543 |
| I | HIS103 |
| I | HIS105 |
| I | CU401 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue CU I 403 |
| Chain | Residue |
| I | HIS232 |
| I | CYS289 |
| I | HIS294 |
| I | MET299 |
| site_id | AG5 |
| Number of Residues | 4 |
| Details | binding site for residue CU I 404 |
| Chain | Residue |
| H | HIS159 |
| I | HIS237 |
| I | HIS288 |
| I | HOH543 |
| site_id | AG6 |
| Number of Residues | 6 |
| Details | binding site for residue CU I 405 |
| Chain | Residue |
| H | HIS103 |
| H | HIS105 |
| H | CU404 |
| I | HIS235 |
| I | HIS237 |
| I | HOH543 |
| site_id | AG7 |
| Number of Residues | 4 |
| Details | binding site for residue CU J 401 |
| Chain | Residue |
| J | HIS232 |
| J | CYS289 |
| J | HIS294 |
| J | MET299 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue CU J 402 |
| Chain | Residue |
| J | HIS237 |
| J | HIS288 |
| J | OXY405 |
| L | HIS159 |
| site_id | AG9 |
| Number of Residues | 6 |
| Details | binding site for residue CU J 403 |
| Chain | Residue |
| J | HIS235 |
| J | HIS237 |
| J | OXY405 |
| L | HIS103 |
| L | HIS105 |
| L | CU401 |
| site_id | AH1 |
| Number of Residues | 5 |
| Details | binding site for residue CU J 404 |
| Chain | Residue |
| J | HIS105 |
| J | HIS157 |
| K | HIS290 |
| K | CU403 |
| K | HOH552 |
| site_id | AH2 |
| Number of Residues | 10 |
| Details | binding site for residue OXY J 405 |
| Chain | Residue |
| J | HIS235 |
| J | HIS237 |
| J | HIS290 |
| J | CU402 |
| J | CU403 |
| L | HIS103 |
| L | HIS105 |
| L | HIS157 |
| L | HIS159 |
| L | CU401 |
| site_id | AH3 |
| Number of Residues | 4 |
| Details | binding site for residue CU K 401 |
| Chain | Residue |
| K | HIS232 |
| K | CYS289 |
| K | HIS294 |
| K | MET299 |
| site_id | AH4 |
| Number of Residues | 4 |
| Details | binding site for residue CU K 402 |
| Chain | Residue |
| J | HIS159 |
| K | HIS237 |
| K | HIS288 |
| K | HOH552 |
| site_id | AH5 |
| Number of Residues | 7 |
| Details | binding site for residue CU K 403 |
| Chain | Residue |
| J | HIS103 |
| J | HIS105 |
| J | CU404 |
| J | HOH503 |
| K | HIS235 |
| K | HIS237 |
| K | HOH552 |
| site_id | AH6 |
| Number of Residues | 6 |
| Details | binding site for residue CU K 404 |
| Chain | Residue |
| K | HIS103 |
| K | HIS105 |
| K | HIS157 |
| L | HIS290 |
| L | CU404 |
| L | HOH539 |
| site_id | AH7 |
| Number of Residues | 5 |
| Details | binding site for residue CU L 401 |
| Chain | Residue |
| J | HIS290 |
| J | CU403 |
| J | OXY405 |
| L | HIS105 |
| L | HIS157 |
| site_id | AH8 |
| Number of Residues | 4 |
| Details | binding site for residue CU L 402 |
| Chain | Residue |
| L | HIS232 |
| L | CYS289 |
| L | HIS294 |
| L | MET299 |
| site_id | AH9 |
| Number of Residues | 4 |
| Details | binding site for residue CU L 403 |
| Chain | Residue |
| K | HIS159 |
| L | HIS237 |
| L | HIS288 |
| L | HOH539 |
| site_id | AI1 |
| Number of Residues | 7 |
| Details | binding site for residue CU L 404 |
| Chain | Residue |
| K | HIS103 |
| K | HIS105 |
| K | CU404 |
| K | HOH505 |
| L | HIS235 |
| L | HIS237 |
| L | HOH539 |
Functional Information from PROSITE/UniProt
| site_id | PS00080 |
| Number of Residues | 12 |
| Details | MULTICOPPER_OXIDASE2 Multicopper oxidases signature 2. HCHvqsHsdmGM |
| Chain | Residue | Details |
| A | HIS288-MET299 |
