6ZI2
OleP-oleandolide(DEO) in low salt crystallization conditions
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0020037 | molecular_function | heme binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| C | 0020037 | molecular_function | heme binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| D | 0020037 | molecular_function | heme binding |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004497 | molecular_function | monooxygenase activity |
| E | 0005506 | molecular_function | iron ion binding |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| E | 0020037 | molecular_function | heme binding |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004497 | molecular_function | monooxygenase activity |
| F | 0005506 | molecular_function | iron ion binding |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| F | 0020037 | molecular_function | heme binding |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0004497 | molecular_function | monooxygenase activity |
| G | 0005506 | molecular_function | iron ion binding |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| G | 0020037 | molecular_function | heme binding |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0004497 | molecular_function | monooxygenase activity |
| H | 0005506 | molecular_function | iron ion binding |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| H | 0020037 | molecular_function | heme binding |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0004497 | molecular_function | monooxygenase activity |
| I | 0005506 | molecular_function | iron ion binding |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| I | 0020037 | molecular_function | heme binding |
| I | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | VAL93 |
| A | LEU290 |
| A | ARG298 |
| A | ALA348 |
| A | PHE349 |
| A | GLY350 |
| A | HIS354 |
| A | CYS356 |
| A | ILE357 |
| A | GLY358 |
| A | QR8502 |
| A | LEU94 |
| A | HOH604 |
| A | HIS101 |
| A | ARG105 |
| A | LEU241 |
| A | ALA244 |
| A | GLY245 |
| A | THR248 |
| A | GLN252 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue QR8 A 502 |
| Chain | Residue |
| A | PHE84 |
| A | LEU94 |
| A | ALA244 |
| A | THR248 |
| A | VAL291 |
| A | PHE296 |
| A | HEM501 |
| A | HOH604 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue HEM B 501 |
| Chain | Residue |
| B | VAL93 |
| B | LEU94 |
| B | HIS101 |
| B | PHE112 |
| B | ALA244 |
| B | GLY245 |
| B | THR248 |
| B | LEU290 |
| B | ARG298 |
| B | ALA348 |
| B | PHE349 |
| B | ALA353 |
| B | HIS354 |
| B | CYS356 |
| B | GLY358 |
| B | QR8502 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue QR8 B 502 |
| Chain | Residue |
| B | PHE84 |
| B | SER240 |
| B | ILE243 |
| B | ALA244 |
| B | LEU396 |
| B | HEM501 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue HEM C 501 |
| Chain | Residue |
| C | VAL93 |
| C | LEU94 |
| C | HIS101 |
| C | ARG105 |
| C | PHE112 |
| C | ALA244 |
| C | THR248 |
| C | LEU290 |
| C | ARG298 |
| C | ALA348 |
| C | PHE349 |
| C | GLY350 |
| C | HIS354 |
| C | CYS356 |
| C | GLY358 |
| C | QR8502 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue QR8 C 502 |
| Chain | Residue |
| C | PHE84 |
| C | ILE243 |
| C | ALA244 |
| C | THR248 |
| C | LEU396 |
| C | HEM501 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | binding site for residue HEM D 501 |
| Chain | Residue |
| D | VAL93 |
| D | LEU94 |
| D | HIS101 |
| D | ARG105 |
| D | LEU241 |
| D | ALA244 |
| D | GLY245 |
| D | THR248 |
| D | LEU290 |
| D | ARG298 |
| D | PHE321 |
| D | ALA348 |
| D | PHE349 |
| D | GLY350 |
| D | HIS354 |
| D | CYS356 |
| D | ILE357 |
| D | GLY358 |
| D | HOH603 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue QR8 D 502 |
| Chain | Residue |
| D | PHE84 |
| D | LEU94 |
| D | ALA244 |
| D | PHE296 |
| D | HOH603 |
| site_id | AC9 |
| Number of Residues | 20 |
| Details | binding site for residue HEM E 501 |
| Chain | Residue |
| E | ARG105 |
| E | LEU241 |
| E | ALA244 |
| E | GLY245 |
| E | THR248 |
| E | GLN252 |
| E | LEU290 |
| E | PHE296 |
| E | ARG298 |
| E | ALA348 |
| E | PHE349 |
| E | ALA353 |
| E | HIS354 |
| E | CYS356 |
| E | ILE357 |
| E | GLY358 |
| E | QR8502 |
| E | VAL93 |
| E | LEU94 |
| E | HIS101 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue QR8 E 502 |
| Chain | Residue |
| E | LEU94 |
| E | ALA244 |
| E | THR248 |
| E | LEU396 |
| E | HEM501 |
| site_id | AD2 |
| Number of Residues | 20 |
| Details | binding site for residue HEM F 501 |
| Chain | Residue |
| F | VAL93 |
| F | LEU94 |
| F | HIS101 |
| F | ARG105 |
| F | LEU241 |
| F | ALA244 |
| F | GLY245 |
| F | THR248 |
| F | GLN252 |
| F | LEU290 |
| F | ARG298 |
| F | ALA348 |
| F | PHE349 |
| F | GLY350 |
| F | HIS354 |
| F | CYS356 |
| F | ILE357 |
| F | GLY358 |
| F | QR8502 |
| F | HOH603 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue QR8 F 502 |
| Chain | Residue |
| F | VAL291 |
| F | GLY294 |
| F | PHE296 |
| F | LEU396 |
| F | HEM501 |
| site_id | AD4 |
| Number of Residues | 14 |
| Details | binding site for residue HEM G 501 |
| Chain | Residue |
| G | VAL93 |
| G | LEU94 |
| G | HIS101 |
| G | LEU241 |
| G | ALA244 |
| G | GLY245 |
| G | THR248 |
| G | ARG298 |
| G | PHE321 |
| G | ALA348 |
| G | PHE349 |
| G | GLY350 |
| G | HIS354 |
| G | CYS356 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue QR8 G 502 |
| Chain | Residue |
| G | PHE84 |
| G | LEU94 |
| G | ALA244 |
| G | THR248 |
| G | LEU396 |
| site_id | AD6 |
| Number of Residues | 21 |
| Details | binding site for residue HEM H 501 |
| Chain | Residue |
| H | VAL93 |
| H | LEU94 |
| H | HIS101 |
| H | ARG105 |
| H | LEU241 |
| H | ALA244 |
| H | GLY245 |
| H | THR248 |
| H | LEU290 |
| H | SER295 |
| H | ARG298 |
| H | PHE321 |
| H | ALA348 |
| H | PHE349 |
| H | GLY350 |
| H | HIS354 |
| H | CYS356 |
| H | ILE357 |
| H | GLY358 |
| H | QR8502 |
| H | HOH603 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue QR8 H 502 |
| Chain | Residue |
| H | PHE84 |
| H | LEU94 |
| H | ALA244 |
| H | THR248 |
| H | PHE296 |
| H | LEU396 |
| H | HEM501 |
| H | HOH603 |
| site_id | AD8 |
| Number of Residues | 15 |
| Details | binding site for residue HEM I 501 |
| Chain | Residue |
| I | HIS101 |
| I | ARG105 |
| I | PHE112 |
| I | ILE157 |
| I | LEU241 |
| I | ALA244 |
| I | GLY245 |
| I | THR248 |
| I | SER249 |
| I | GLN252 |
| I | HIS354 |
| I | CYS356 |
| I | GLY358 |
| I | GLY362 |
| I | QR8502 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide QLK I 502 and SER I 240 |
| Chain | Residue |
| I | MET237 |
| I | GLY238 |
| I | VAL239 |
| I | LEU241 |
| I | LEU242 |
| I | ILE243 |
| I | ALA244 |
| I | HEM501 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGAHHCIG |
| Chain | Residue | Details |
| A | PHE349-GLY358 |
