6ZH2
Cryo-EM structure of DNA-PKcs (State 1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000460 | biological_process | maturation of 5.8S rRNA |
| A | 0000723 | biological_process | telomere maintenance |
| A | 0000781 | cellular_component | chromosome, telomeric region |
| A | 0000785 | cellular_component | chromatin |
| A | 0001933 | biological_process | negative regulation of protein phosphorylation |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0003690 | molecular_function | double-stranded DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004677 | molecular_function | DNA-dependent protein kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005667 | cellular_component | transcription regulator complex |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005958 | cellular_component | DNA-dependent protein kinase-DNA ligase 4 complex |
| A | 0006281 | biological_process | DNA repair |
| A | 0006302 | biological_process | double-strand break repair |
| A | 0006303 | biological_process | double-strand break repair via nonhomologous end joining |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008630 | biological_process | intrinsic apoptotic signaling pathway in response to DNA damage |
| A | 0016020 | cellular_component | membrane |
| A | 0016233 | biological_process | telomere capping |
| A | 0016301 | molecular_function | kinase activity |
| A | 0018105 | biological_process | peptidyl-serine phosphorylation |
| A | 0018107 | biological_process | peptidyl-threonine phosphorylation |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0031571 | biological_process | mitotic G1 DNA damage checkpoint signaling |
| A | 0032040 | cellular_component | small-subunit processome |
| A | 0032869 | biological_process | cellular response to insulin stimulus |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0032993 | cellular_component | protein-DNA complex |
| A | 0033152 | biological_process | immunoglobulin V(D)J recombination |
| A | 0034462 | biological_process | small-subunit processome assembly |
| A | 0034511 | molecular_function | U3 snoRNA binding |
| A | 0035979 | molecular_function | histone H2AXS139 kinase activity |
| A | 0036211 | biological_process | protein modification process |
| A | 0042752 | biological_process | regulation of circadian rhythm |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0045621 | biological_process | positive regulation of lymphocyte differentiation |
| A | 0045648 | biological_process | positive regulation of erythrocyte differentiation |
| A | 0045727 | biological_process | positive regulation of translation |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0048660 | biological_process | regulation of smooth muscle cell proliferation |
| A | 0050678 | biological_process | regulation of epithelial cell proliferation |
| A | 0061629 | molecular_function | RNA polymerase II-specific DNA-binding transcription factor binding |
| A | 0070419 | cellular_component | nonhomologous end joining complex |
| A | 0080135 | biological_process | regulation of cellular response to stress |
| A | 0097681 | biological_process | double-strand break repair via alternative nonhomologous end joining |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
| A | 1902036 | biological_process | regulation of hematopoietic stem cell differentiation |
| A | 1905221 | biological_process | positive regulation of platelet formation |
| A | 2001034 | biological_process | positive regulation of double-strand break repair via nonhomologous end joining |
Functional Information from PROSITE/UniProt
| site_id | PS00915 |
| Number of Residues | 15 |
| Details | PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgg.EDLRQDqrveQ |
| Chain | Residue | Details |
| A | VAL3752-GLN3766 |
| site_id | PS00916 |
| Number of Residues | 21 |
| Details | PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ShAlicIshWILgIgDRHlnN |
| Chain | Residue | Details |
| A | SER3907-ASN3927 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"HEAT 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 28 |
| Details | Repeat: {"description":"TPR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 331 |
| Details | Domain: {"description":"PI3K/PI4K catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 32 |
| Details | Domain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 35 |
| Details | Region: {"description":"Leucine-zipper"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 25 |
| Details | Region: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 9 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
