6ZG0

SARM1 SAM1-2 domains

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0003953	molecular_function	NAD+ nucleosidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005829	cellular_component	cytosol
A	0005874	cellular_component	microtubule
A	0007165	biological_process	signal transduction
A	0007399	biological_process	nervous system development
A	0009749	biological_process	response to glucose
A	0009986	cellular_component	cell surface
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0019677	biological_process	NAD+ catabolic process
A	0030154	biological_process	cell differentiation
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0031594	cellular_component	neuromuscular junction
A	0032991	cellular_component	protein-containing complex
A	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
A	0035591	molecular_function	signaling adaptor activity
A	0043523	biological_process	regulation of neuron apoptotic process
A	0045087	biological_process	innate immune response
A	0045202	cellular_component	synapse
A	0048678	biological_process	response to axon injury
A	0048814	biological_process	regulation of dendrite morphogenesis
A	0050135	molecular_function	NADP+ nucleosidase activity
A	0050877	biological_process	nervous system process
A	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
A	0070585	biological_process	protein localization to mitochondrion
A	0098978	cellular_component	glutamatergic synapse
A	0099010	biological_process	modification of postsynaptic structure
A	0099243	cellular_component	extrinsic component of synaptic membrane
A	1905806	biological_process	regulation of synapse pruning
B	0002376	biological_process	immune system process
B	0003953	molecular_function	NAD+ nucleosidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005829	cellular_component	cytosol
B	0005874	cellular_component	microtubule
B	0007165	biological_process	signal transduction
B	0007399	biological_process	nervous system development
B	0009749	biological_process	response to glucose
B	0009986	cellular_component	cell surface
B	0015630	cellular_component	microtubule cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0019677	biological_process	NAD+ catabolic process
B	0030154	biological_process	cell differentiation
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0031594	cellular_component	neuromuscular junction
B	0032991	cellular_component	protein-containing complex
B	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
B	0035591	molecular_function	signaling adaptor activity
B	0043523	biological_process	regulation of neuron apoptotic process
B	0045087	biological_process	innate immune response
B	0045202	cellular_component	synapse
B	0048678	biological_process	response to axon injury
B	0048814	biological_process	regulation of dendrite morphogenesis
B	0050135	molecular_function	NADP+ nucleosidase activity
B	0050877	biological_process	nervous system process
B	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
B	0070585	biological_process	protein localization to mitochondrion
B	0098978	cellular_component	glutamatergic synapse
B	0099010	biological_process	modification of postsynaptic structure
B	0099243	cellular_component	extrinsic component of synaptic membrane
B	1905806	biological_process	regulation of synapse pruning
C	0002376	biological_process	immune system process
C	0003953	molecular_function	NAD+ nucleosidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005829	cellular_component	cytosol
C	0005874	cellular_component	microtubule
C	0007165	biological_process	signal transduction
C	0007399	biological_process	nervous system development
C	0009749	biological_process	response to glucose
C	0009986	cellular_component	cell surface
C	0015630	cellular_component	microtubule cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0019677	biological_process	NAD+ catabolic process
C	0030154	biological_process	cell differentiation
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0031594	cellular_component	neuromuscular junction
C	0032991	cellular_component	protein-containing complex
C	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
C	0035591	molecular_function	signaling adaptor activity
C	0043523	biological_process	regulation of neuron apoptotic process
C	0045087	biological_process	innate immune response
C	0045202	cellular_component	synapse
C	0048678	biological_process	response to axon injury
C	0048814	biological_process	regulation of dendrite morphogenesis
C	0050135	molecular_function	NADP+ nucleosidase activity
C	0050877	biological_process	nervous system process
C	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
C	0070585	biological_process	protein localization to mitochondrion
C	0098978	cellular_component	glutamatergic synapse
C	0099010	biological_process	modification of postsynaptic structure
C	0099243	cellular_component	extrinsic component of synaptic membrane
C	1905806	biological_process	regulation of synapse pruning
D	0002376	biological_process	immune system process
D	0003953	molecular_function	NAD+ nucleosidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005829	cellular_component	cytosol
D	0005874	cellular_component	microtubule
D	0007165	biological_process	signal transduction
D	0007399	biological_process	nervous system development
D	0009749	biological_process	response to glucose
D	0009986	cellular_component	cell surface
D	0015630	cellular_component	microtubule cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0019677	biological_process	NAD+ catabolic process
D	0030154	biological_process	cell differentiation
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0031594	cellular_component	neuromuscular junction
D	0032991	cellular_component	protein-containing complex
D	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
D	0035591	molecular_function	signaling adaptor activity
D	0043523	biological_process	regulation of neuron apoptotic process
D	0045087	biological_process	innate immune response
D	0045202	cellular_component	synapse
D	0048678	biological_process	response to axon injury
D	0048814	biological_process	regulation of dendrite morphogenesis
D	0050135	molecular_function	NADP+ nucleosidase activity
D	0050877	biological_process	nervous system process
D	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
D	0070585	biological_process	protein localization to mitochondrion
D	0098978	cellular_component	glutamatergic synapse
D	0099010	biological_process	modification of postsynaptic structure
D	0099243	cellular_component	extrinsic component of synaptic membrane
D	1905806	biological_process	regulation of synapse pruning
E	0002376	biological_process	immune system process
E	0003953	molecular_function	NAD+ nucleosidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005829	cellular_component	cytosol
E	0005874	cellular_component	microtubule
E	0007165	biological_process	signal transduction
E	0007399	biological_process	nervous system development
E	0009749	biological_process	response to glucose
E	0009986	cellular_component	cell surface
E	0015630	cellular_component	microtubule cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0019677	biological_process	NAD+ catabolic process
E	0030154	biological_process	cell differentiation
E	0030424	cellular_component	axon
E	0030425	cellular_component	dendrite
E	0031594	cellular_component	neuromuscular junction
E	0032991	cellular_component	protein-containing complex
E	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
E	0035591	molecular_function	signaling adaptor activity
E	0043523	biological_process	regulation of neuron apoptotic process
E	0045087	biological_process	innate immune response
E	0045202	cellular_component	synapse
E	0048678	biological_process	response to axon injury
E	0048814	biological_process	regulation of dendrite morphogenesis
E	0050135	molecular_function	NADP+ nucleosidase activity
E	0050877	biological_process	nervous system process
E	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
E	0070585	biological_process	protein localization to mitochondrion
E	0098978	cellular_component	glutamatergic synapse
E	0099010	biological_process	modification of postsynaptic structure
E	0099243	cellular_component	extrinsic component of synaptic membrane
E	1905806	biological_process	regulation of synapse pruning
F	0002376	biological_process	immune system process
F	0003953	molecular_function	NAD+ nucleosidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005829	cellular_component	cytosol
F	0005874	cellular_component	microtubule
F	0007165	biological_process	signal transduction
F	0007399	biological_process	nervous system development
F	0009749	biological_process	response to glucose
F	0009986	cellular_component	cell surface
F	0015630	cellular_component	microtubule cytoskeleton
F	0016787	molecular_function	hydrolase activity
F	0019677	biological_process	NAD+ catabolic process
F	0030154	biological_process	cell differentiation
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0031594	cellular_component	neuromuscular junction
F	0032991	cellular_component	protein-containing complex
F	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
F	0035591	molecular_function	signaling adaptor activity
F	0043523	biological_process	regulation of neuron apoptotic process
F	0045087	biological_process	innate immune response
F	0045202	cellular_component	synapse
F	0048678	biological_process	response to axon injury
F	0048814	biological_process	regulation of dendrite morphogenesis
F	0050135	molecular_function	NADP+ nucleosidase activity
F	0050877	biological_process	nervous system process
F	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
F	0070585	biological_process	protein localization to mitochondrion
F	0098978	cellular_component	glutamatergic synapse
F	0099010	biological_process	modification of postsynaptic structure
F	0099243	cellular_component	extrinsic component of synaptic membrane
F	1905806	biological_process	regulation of synapse pruning
G	0002376	biological_process	immune system process
G	0003953	molecular_function	NAD+ nucleosidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0005829	cellular_component	cytosol
G	0005874	cellular_component	microtubule
G	0007165	biological_process	signal transduction
G	0007399	biological_process	nervous system development
G	0009749	biological_process	response to glucose
G	0009986	cellular_component	cell surface
G	0015630	cellular_component	microtubule cytoskeleton
G	0016787	molecular_function	hydrolase activity
G	0019677	biological_process	NAD+ catabolic process
G	0030154	biological_process	cell differentiation
G	0030424	cellular_component	axon
G	0030425	cellular_component	dendrite
G	0031594	cellular_component	neuromuscular junction
G	0032991	cellular_component	protein-containing complex
G	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
G	0035591	molecular_function	signaling adaptor activity
G	0043523	biological_process	regulation of neuron apoptotic process
G	0045087	biological_process	innate immune response
G	0045202	cellular_component	synapse
G	0048678	biological_process	response to axon injury
G	0048814	biological_process	regulation of dendrite morphogenesis
G	0050135	molecular_function	NADP+ nucleosidase activity
G	0050877	biological_process	nervous system process
G	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
G	0070585	biological_process	protein localization to mitochondrion
G	0098978	cellular_component	glutamatergic synapse
G	0099010	biological_process	modification of postsynaptic structure
G	0099243	cellular_component	extrinsic component of synaptic membrane
G	1905806	biological_process	regulation of synapse pruning
H	0002376	biological_process	immune system process
H	0003953	molecular_function	NAD+ nucleosidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0005829	cellular_component	cytosol
H	0005874	cellular_component	microtubule
H	0007165	biological_process	signal transduction
H	0007399	biological_process	nervous system development
H	0009749	biological_process	response to glucose
H	0009986	cellular_component	cell surface
H	0015630	cellular_component	microtubule cytoskeleton
H	0016787	molecular_function	hydrolase activity
H	0019677	biological_process	NAD+ catabolic process
H	0030154	biological_process	cell differentiation
H	0030424	cellular_component	axon
H	0030425	cellular_component	dendrite
H	0031594	cellular_component	neuromuscular junction
H	0032991	cellular_component	protein-containing complex
H	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
H	0035591	molecular_function	signaling adaptor activity
H	0043523	biological_process	regulation of neuron apoptotic process
H	0045087	biological_process	innate immune response
H	0045202	cellular_component	synapse
H	0048678	biological_process	response to axon injury
H	0048814	biological_process	regulation of dendrite morphogenesis
H	0050135	molecular_function	NADP+ nucleosidase activity
H	0050877	biological_process	nervous system process
H	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
H	0070585	biological_process	protein localization to mitochondrion
H	0098978	cellular_component	glutamatergic synapse
H	0099010	biological_process	modification of postsynaptic structure
H	0099243	cellular_component	extrinsic component of synaptic membrane
H	1905806	biological_process	regulation of synapse pruning

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue EDO A 801

Chain	Residue
A	LYS428
A	SER432
A	LEU455

---

site_id	AC2
Number of Residues	2
Details	binding site for residue BME A 802

Chain	Residue
A	CYS482
A	TYR503

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 803

Chain	Residue
A	GLY425
A	LYS428
A	ARG465
B	GLN437

---

site_id	AC4
Number of Residues	2
Details	binding site for residue EDO B 801

Chain	Residue
B	LEU444
B	GLY504

---

site_id	AC5
Number of Residues	8
Details	binding site for residue EDO B 802

Chain	Residue
B	ALA477
B	ASN478
B	TYR479
B	SER480
B	ASP483
B	ASN486
B	ALA488
B	ARG499

---

site_id	AC6
Number of Residues	4
Details	binding site for residue PEG B 803

Chain	Residue
B	ARG497
B	GLN500
B	HIS534
C	SER507

---

site_id	AC7
Number of Residues	9
Details	binding site for residue PGE B 805

Chain	Residue
B	PRO402
B	ARG403
B	PRO404
B	TRP412
B	GLU416
B	TRP420
B	GLN423
B	GLU472
B	LEU473

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO B 806

Chain	Residue
B	LEU524
B	HIS530
B	ARG535
C	GLU525

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO B 807

Chain	Residue
B	LYS428
B	SER432
B	LEU455

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO C 802

Chain	Residue
C	SER513
C	HIS547
C	SER548

---

site_id	AD2
Number of Residues	2
Details	binding site for residue EDO C 803

Chain	Residue
C	HIS516
C	ARG517

---

site_id	AD3
Number of Residues	2
Details	binding site for residue EDO C 804

Chain	Residue
C	TRP420
C	GLU469

---

site_id	AD4
Number of Residues	5
Details	binding site for residue EDO D 801

Chain	Residue
D	GLY425
D	PHE426
D	TYR429
D	ARG465
E	GLN437

---

site_id	AD5
Number of Residues	8
Details	binding site for residue PEG D 802

Chain	Residue
D	ALA477
D	ASN478
D	TYR479
D	SER480
D	ASP483
D	ASN486
D	ALA488
D	ARG499

---

site_id	AD6
Number of Residues	2
Details	binding site for residue EDO D 804

Chain	Residue
D	ASP489
D	ARG512

---

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO D 805

Chain	Residue
D	LYS428
D	SER432
D	LEU455

---

site_id	AD8
Number of Residues	2
Details	binding site for residue EDO D 806

Chain	Residue
D	GLU448
D	ARG463

---

site_id	AD9
Number of Residues	5
Details	binding site for residue EDO D 807

Chain	Residue
D	GLN452
D	LYS458
D	ARG463
E	GLU449
E	ASP454

---

site_id	AE1
Number of Residues	4
Details	binding site for residue EDO D 808

Chain	Residue
D	ARG465
D	ARG468
E	GLN437
E	ASP439

---

site_id	AE2
Number of Residues	7
Details	binding site for residue EDO E 801

Chain	Residue
D	GLU520
D	GLY532
D	ARG535
E	GLN521
E	GLN522
E	GLU525
E	ASP526

---

site_id	AE3
Number of Residues	3
Details	binding site for residue EDO F 801

Chain	Residue
E	SER459
F	GLN436
F	ASP454

---

site_id	AE4
Number of Residues	5
Details	binding site for Di-peptide BME B 804 and CYS B 482

Chain	Residue
B	TYR479
B	SER480
B	THR481
B	ASP483
B	VAL506

---

site_id	AE5
Number of Residues	6
Details	binding site for Di-peptide BME C 801 and CYS C 482

Chain	Residue
C	TYR479
C	SER480
C	THR481
C	ASP483
C	TYR503
C	VAL506

---

site_id	AE6
Number of Residues	7
Details	binding site for Di-peptide BME D 803 and CYS D 482

Chain	Residue
D	THR481
D	ASP483
D	VAL506
D	SER507
C	ARG497
D	TYR479
D	SER480

---

site_id	AE7
Number of Residues	6
Details	binding site for Di-peptide BME E 802 and CYS E 482

Chain	Residue
E	TYR479
E	SER480
E	THR481
E	ASP483
E	VAL506
E	SER507

---

site_id	AE8
Number of Residues	7
Details	binding site for Di-peptide BME F 802 and CYS F 482

Chain	Residue
F	TYR479
F	SER480
F	THR481
F	ASP483
F	TYR503
F	VAL506
F	SER507

---

site_id	AE9
Number of Residues	6
Details	binding site for Di-peptide BME G 801 and CYS G 482

Chain	Residue
G	TYR479
G	SER480
G	THR481
G	ASP483
G	VAL506
G	SER507

---

site_id	AF1
Number of Residues	7
Details	binding site for Di-peptide BME H 801 and CYS H 482

Chain	Residue
H	TYR479
H	SER480
H	THR481
H	ASP483
H	ARG484
H	VAL506
H	SER507

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	512
Details	Domain: {"description":"SAM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	248
Details	Domain: {"description":"SAM 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30333228","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---