6ZFE
Crystal structure of murine S100A9 mutant C80A bound to calcium and zinc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001533 | cellular_component | cornified envelope |
| A | 0002376 | biological_process | immune system process |
| A | 0002523 | biological_process | leukocyte migration involved in inflammatory response |
| A | 0002544 | biological_process | chronic inflammatory response |
| A | 0002793 | biological_process | positive regulation of peptide secretion |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006417 | biological_process | regulation of translation |
| A | 0006914 | biological_process | autophagy |
| A | 0006915 | biological_process | apoptotic process |
| A | 0006935 | biological_process | chemotaxis |
| A | 0006954 | biological_process | inflammatory response |
| A | 0010976 | biological_process | positive regulation of neuron projection development |
| A | 0014002 | biological_process | astrocyte development |
| A | 0016209 | molecular_function | antioxidant activity |
| A | 0018119 | biological_process | peptidyl-cysteine S-nitrosylation |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0030194 | biological_process | positive regulation of blood coagulation |
| A | 0030593 | biological_process | neutrophil chemotaxis |
| A | 0030595 | biological_process | leukocyte chemotaxis |
| A | 0034121 | biological_process | regulation of toll-like receptor signaling pathway |
| A | 0035425 | biological_process | autocrine signaling |
| A | 0043542 | biological_process | endothelial cell migration |
| A | 0045087 | biological_process | innate immune response |
| A | 0045113 | biological_process | regulation of integrin biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| A | 0060264 | biological_process | regulation of respiratory burst involved in inflammatory response |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| A | 0070488 | biological_process | neutrophil aggregation |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 1990660 | cellular_component | calprotectin complex |
| A | 1990662 | cellular_component | S100A9 complex |
| A | 2001244 | biological_process | positive regulation of intrinsic apoptotic signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 201 |
| Chain | Residue |
| A | SER24 |
| A | GLU27 |
| A | HIS29 |
| A | THR32 |
| A | GLU37 |
| A | HOH304 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 202 |
| Chain | Residue |
| A | GLN74 |
| A | GLU79 |
| A | ASP68 |
| A | ASN70 |
| A | ASP72 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 203 |
| Chain | Residue |
| A | HIS21 |
| A | ASP31 |
| A | HIS92 |
| A | HIS96 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 204 |
| Chain | Residue |
| A | GLU65 |
| A | HIS103 |
| A | HIS105 |
| A | HIS107 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 205 |
| Chain | Residue |
| A | ASP31 |
| A | GLU78 |
| A | HIS92 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 206 |
| Chain | Residue |
| A | LYS35 |
| A | LYS35 |
| A | ARG39 |
| A | ARG39 |
| A | ASN61 |
| A | ASN61 |
| A | HIS105 |
| A | HIS105 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 207 |
| Chain | Residue |
| A | ARG11 |
| A | ARG11 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 208 |
| Chain | Residue |
| A | HIS21 |
| A | HIS96 |
| A | ASN99 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 13 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P06702","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Pros-methylhistidine","evidences":[{"source":"PubMed","id":"33563959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34562450","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
