6Z7V

Crystal structure of Mindy2 (C266A) in complex with Lys48 linked di-ubiquitin (K48-Ub2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	1990380	molecular_function	K48-linked deubiquitinase activity
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	1990380	molecular_function	K48-linked deubiquitinase activity

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
C	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
C	ARG54
G	ARG72
H	ARG54
H	ARG72
I	ARG54
I	ARG72
C	ARG72
D	ARG54
D	ARG72
E	ARG54
E	ARG72
F	ARG54
F	ARG72
G	ARG54

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site_id	SWS_FT_FI2
Number of Residues	7
Details	SITE: Essential for function

Chain	Residue	Details
C	HIS68
D	HIS68
E	HIS68
F	HIS68
G	HIS68
H	HIS68
I	HIS68

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site_id	SWS_FT_FI3
Number of Residues	7
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291

Chain	Residue	Details
C	SER65
D	SER65
E	SER65
F	SER65
G	SER65
H	SER65
I	SER65

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457

Chain	Residue	Details
C	THR66
D	THR66
E	THR66
F	THR66
G	THR66
H	THR66
I	THR66

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
C	GLY76
D	GLY76
E	GLY76
F	GLY76
G	GLY76
H	GLY76
I	GLY76

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603

Chain	Residue	Details
C	LYS6
D	LYS6
E	LYS6
F	LYS6
G	LYS6
H	LYS6
I	LYS6

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site_id	SWS_FT_FI7
Number of Residues	14
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
G	GLY76
H	GLY76
I	GLY76
C	GLY76
D	GLY76
E	GLY76
F	GLY76

---

site_id	SWS_FT_FI8
Number of Residues	14
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144

Chain	Residue	Details
C	LYS11
G	LYS48
H	LYS11
H	LYS48
I	LYS11
I	LYS48
C	LYS48
D	LYS11
D	LYS48
E	LYS11
E	LYS48
F	LYS11
F	LYS48
G	LYS11

---

site_id	SWS_FT_FI9
Number of Residues	7
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860

Chain	Residue	Details
C	LYS27
D	LYS27
E	LYS27
F	LYS27
G	LYS27
H	LYS27
I	LYS27

---

site_id	SWS_FT_FI10
Number of Residues	7
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127

Chain	Residue	Details
C	LYS29
D	LYS29
E	LYS29
F	LYS29
G	LYS29
H	LYS29
I	LYS29

---

site_id	SWS_FT_FI11
Number of Residues	7
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577

Chain	Residue	Details
C	LYS33
D	LYS33
E	LYS33
F	LYS33
G	LYS33
H	LYS33
I	LYS33

---

site_id	SWS_FT_FI12
Number of Residues	7
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106

Chain	Residue	Details
C	LYS63
D	LYS63
E	LYS63
F	LYS63
G	LYS63
H	LYS63
I	LYS63

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