Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue A3R A 401 |
| Chain | Residue |
| A | ASP226 |
| A | VAL253 |
| A | ALA254 |
| A | LEU330 |
| A | SER332 |
| A | ALA333 |
| A | GLY334 |
| A | ILE335 |
| A | PHE336 |
| A | ALA358 |
| A | PHE360 |
| A | ILE227 |
| A | HOH506 |
| A | HOH510 |
| A | HOH512 |
| A | HOH521 |
| A | HOH527 |
| A | ALA242 |
| A | ALA243 |
| A | ASN244 |
| A | LYS248 |
| A | GLY250 |
| A | GLY251 |
| A | GLY252 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | GLY212 |
| A | LYS223 |
| A | ASN224 |
| A | TYR365 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | ARG345 |
| A | ASP349 |
| A | MET375 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 404 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 405 |
| Chain | Residue |
| A | SER209 |
| A | PHE210 |
| A | SER211 |
| A | LYS223 |
| A | GLU230 |
| A | VAL234 |
| A | HOH552 |
| site_id | AC6 |
| Number of Residues | 22 |
| Details | binding site for residue A3R B 401 |
| Chain | Residue |
| B | ASP226 |
| B | ILE227 |
| B | ALA242 |
| B | ASN244 |
| B | LYS248 |
| B | GLY250 |
| B | GLY251 |
| B | GLY252 |
| B | VAL253 |
| B | LEU330 |
| B | SER332 |
| B | ALA333 |
| B | GLY334 |
| B | ILE335 |
| B | PHE336 |
| B | ALA358 |
| B | PHE360 |
| B | HOH503 |
| B | HOH511 |
| B | HOH518 |
| B | HOH527 |
| B | HOH535 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 402 |
| Chain | Residue |
| B | THR217 |
| B | ASP218 |
| B | LYS376 |
| B | HOH526 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue NA B 403 |
| Chain | Residue |
| B | SER211 |
| B | LYS223 |
| B | GLU230 |
| site_id | AC9 |
| Number of Residues | 23 |
| Details | binding site for residue A3R C 401 |
| Chain | Residue |
| C | ASP226 |
| C | ILE227 |
| C | ALA242 |
| C | ALA243 |
| C | ASN244 |
| C | GLY251 |
| C | GLY252 |
| C | VAL253 |
| C | LEU330 |
| C | SER332 |
| C | ALA333 |
| C | GLY334 |
| C | ILE335 |
| C | PHE336 |
| C | ALA358 |
| C | PHE360 |
| C | HOH510 |
| C | HOH511 |
| C | HOH513 |
| C | HOH522 |
| C | HOH542 |
| C | HOH548 |
| D | HOH528 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 402 |
| Chain | Residue |
| C | ASN263 |
| C | VAL267 |
| C | ASP270 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 403 |
| Chain | Residue |
| C | HOH535 |
| C | SER211 |
| C | GLY212 |
| C | TYR213 |
| C | TYR221 |
| C | TYR356 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue NA C 404 |
| Chain | Residue |
| C | SER211 |
| C | HOH525 |
| site_id | AD4 |
| Number of Residues | 21 |
| Details | binding site for residue A3R D 401 |
| Chain | Residue |
| D | ASP226 |
| D | ILE227 |
| D | ALA242 |
| D | ASN244 |
| D | GLY250 |
| D | GLY251 |
| D | GLY252 |
| D | VAL253 |
| D | LEU330 |
| D | SER332 |
| D | ALA333 |
| D | GLY334 |
| D | ILE335 |
| D | PHE336 |
| D | ALA358 |
| D | PHE360 |
| D | HOH505 |
| D | HOH510 |
| D | HOH531 |
| D | HOH532 |
| D | HOH537 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue MLT D 402 |
| Chain | Residue |
| D | LYS259 |
| D | ALA260 |
| D | ASN262 |
| D | HOH511 |
| D | HOH538 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 403 |
| Chain | Residue |
| D | SER211 |
| D | GLY212 |
| D | TYR213 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue NA D 404 |
| Chain | Residue |
| D | SER211 |
| D | LYS223 |
| D | GLU230 |
| D | VAL234 |
| D | HOH577 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 676 |
| Details | Domain: {"description":"Macro 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00490","evidenceCode":"ECO:0000255"}]} |
