6Z58

Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003791

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue Q9B A 801

Chain	Residue
A	ILE490
A	ILE686
A	ASP687
A	HOH1026
A	ALA509
A	LYS511
A	PHE605
A	GLU606
A	PHE607
A	GLY608
A	GLY609
A	LEU656

---

site_id	AC2
Number of Residues	5
Details	binding site for residue NA A 802

Chain	Residue
A	GLU554
A	PHE556
A	SER684
A	HOH992
A	HOH1091

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MPD A 803

Chain	Residue
A	GLU728
A	TYR739
A	LEU782
A	PHE784
A	SER785

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGVFGEVFqTiadhtp............VAIK

Chain	Residue	Details
A	ILE490-LYS511

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	314
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19918057","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3DLZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19918057","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---