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6Z57

Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004078

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue Q8W A 801
ChainResidue
AILE490
ALEU656
AILE686
AASP687
AHOH909
AHOH921
AHOH1182
AGLU492
APHE495
AALA509
ALYS511
APHE605
AGLU606
AGLY608
AGLY609

site_idAC2
Number of Residues5
Detailsbinding site for residue NA A 802
ChainResidue
AGLU554
APHE556
ASER684
AHOH1040
AHOH1155

site_idAC3
Number of Residues3
Detailsbinding site for residue MPD A 803
ChainResidue
ATYR736
AHIS737
AHOH1116

site_idAC4
Number of Residues6
Detailsbinding site for residue MRD A 804
ChainResidue
AGLU728
ATYR739
ALEU782
AASN783
APHE784
ASER785

site_idAC5
Number of Residues4
Detailsbinding site for residue MPD A 805
ChainResidue
AILE537
APRO571
AILE698
AHOH984

site_idAC6
Number of Residues4
Detailsbinding site for residue DMS A 806
ChainResidue
ATYR667
ALYS672
ASER674
AHOH1112

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues22
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGVFGEVFqTiadhtp............VAIK
ChainResidueDetails
AILE490-LYS511

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AASP649

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE490
ALYS511

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:19918057, ECO:0007744|PDB:3DLZ
ChainResidueDetails
AGLU606
AASP649

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:19918057
ChainResidueDetails
AASP687

223532

PDB entries from 2024-08-07

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