6Z4X

Structure of the CAK complex form Chaetomium thermophilum bound to ATP-gamma-S

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
B	0000166	molecular_function	nucleotide binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005675	cellular_component	transcription factor TFIIH holo complex
B	0005737	cellular_component	cytoplasm
B	0006468	biological_process	protein phosphorylation
B	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0051726	biological_process	regulation of cell cycle
B	0070985	cellular_component	transcription factor TFIIK complex
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
E	0000166	molecular_function	nucleotide binding
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005675	cellular_component	transcription factor TFIIH holo complex
E	0005737	cellular_component	cytoplasm
E	0006468	biological_process	protein phosphorylation
E	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0051726	biological_process	regulation of cell cycle
E	0070985	cellular_component	transcription factor TFIIK complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue AGS B 501

Chain	Residue
B	LEU98
B	THR102
B	TYR103
B	VAL106
B	ALA120
B	LYS122
B	GLU173
B	LEU175
B	MG502

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site_id	AC2
Number of Residues	3
Details	binding site for residue MG B 502

Chain	Residue
B	ASN225
B	ASP238
B	AGS501

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site_id	AC3
Number of Residues	6
Details	binding site for residue CL B 503

Chain	Residue
B	ARG191
B	TYR192
B	ARG292
E	ARG191
E	TYR192
E	ARG292

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site_id	AC4
Number of Residues	9
Details	binding site for residue AGS E 501

Chain	Residue
E	LEU98
E	GLY99
E	GLY101
E	THR102
E	VAL106
E	LYS122
E	GLU173
E	LEU175
E	MG502

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site_id	AC5
Number of Residues	3
Details	binding site for residue MG E 502

Chain	Residue
E	ASN225
E	ASP238
E	AGS501

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	26
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGTYANVYlGhsrddpnfkv........AIKK

Chain	Residue	Details
B	LEU98-LYS123

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDIKpnNLLI

Chain	Residue	Details
B	ILE216-ILE228

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