6Z3Y
CryoEM structure of horse sodium/proton exchanger NHE9 in an inward-facing conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0006885 | biological_process | regulation of pH |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015385 | molecular_function | sodium:proton antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0006885 | biological_process | regulation of pH |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015385 | molecular_function | sodium:proton antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| B | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| B | ALA21-PHE41 | |
| A | ALA21-PHE41 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 144 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:33118634 |
| Chain | Residue | Details |
| B | LYS42-ARG45 | |
| A | LEU299-LYS301 | |
| A | THR344-LEU364 | |
| A | ARG408-TRP429 | |
| B | TYR148-THR164 | |
| B | GLU225-LEU235 | |
| B | LEU299-LYS301 | |
| B | THR344-LEU364 | |
| B | ARG408-TRP429 | |
| A | LYS42-ARG45 | |
| A | TYR148-THR164 | |
| A | GLU225-LEU235 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE46-LEU66 | |
| A | PHE46-LEU66 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 222 |
| Details | TOPO_DOM: Lumenal => ECO:0000305|PubMed:33118634 |
| Chain | Residue | Details |
| B | ARG67-LYS126 | |
| A | ARG451-THR465 | |
| B | LYS186-ASP203 | |
| B | TYR257-ASN277 | |
| B | THR386 | |
| B | ARG451-THR465 | |
| A | ARG67-LYS126 | |
| A | LYS186-ASP203 | |
| A | TYR257-ASN277 | |
| A | THR386 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| B | MET127-GLY147 | |
| A | MET127-GLY147 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| B | TYR165-VAL185 | |
| A | TYR165-VAL185 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| B | CYS204-HIS224 | |
| A | CYS204-HIS224 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU236-ILE256 | |
| A | LEU236-ILE256 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE278-LEU298 | |
| A | PHE278-LEU298 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE302-SER322 | |
| A | PHE302-SER322 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255 |
| Chain | Residue | Details |
| B | ALA323-VAL343 | |
| A | ALA323-VAL343 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=100 => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE365-PHE385 | |
| A | PHE365-PHE385 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE387-ALA407 | |
| A | PHE387-ALA407 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN430-ILE450 | |
| A | ASN430-ILE450 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=13 => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU466-TRP486 | |
| A | LEU466-TRP486 |
