6Z3U

Structure of the CAK complex form Chaetomium thermophilum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
A	0070985	cellular_component	transcription factor TFIIK complex
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005675	cellular_component	transcription factor TFIIH holo complex
B	0005737	cellular_component	cytoplasm
B	0006468	biological_process	protein phosphorylation
B	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0051726	biological_process	regulation of cell cycle
B	0070985	cellular_component	transcription factor TFIIK complex
D	0005634	cellular_component	nucleus
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
D	0070985	cellular_component	transcription factor TFIIK complex
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005675	cellular_component	transcription factor TFIIH holo complex
E	0005737	cellular_component	cytoplasm
E	0006468	biological_process	protein phosphorylation
E	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0051726	biological_process	regulation of cell cycle
E	0070985	cellular_component	transcription factor TFIIK complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CL E 501

Chain	Residue
B	ARG191
B	TYR192
B	ARG292
E	ARG191
E	TYR192
E	ARG292

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	26
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGTYANVYlGhsrddpnfkv........AIKK

Chain	Residue	Details
B	LEU98-LYS123

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDIKpnNLLI

Chain	Residue	Details
B	ILE216-ILE228

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