6YXH

Cryogenic human alkaline ceramidase 3 (ACER3) at 2.6 A resolution determined by Serial Crystallography (SSX) using CrystalDirect

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0005506	molecular_function	iron ion binding
A	0005509	molecular_function	calcium ion binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006665	biological_process	sphingolipid metabolic process
A	0006672	biological_process	ceramide metabolic process
A	0006954	biological_process	inflammatory response
A	0008270	molecular_function	zinc ion binding
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0017040	molecular_function	N-acylsphingosine amidohydrolase activity
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042552	biological_process	myelination
A	0043067	biological_process	regulation of programmed cell death
A	0046512	biological_process	sphingosine biosynthetic process
A	0046514	biological_process	ceramide catabolic process
A	0071602	biological_process	phytosphingosine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN A 401

Chain	Residue
A	HIS81
A	HIS217
A	HIS221

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 402

Chain	Residue
A	GLU60
A	LYS61
A	ARG62
A	MG412
A	HOH501

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 403

Chain	Residue
A	LYS259
A	LYS339
A	ARG342
A	HOH501
A	LYS61

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 404

Chain	Residue
A	PHE111
A	ARG159
A	HOH505
A	HOH513

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 405

Chain	Residue
A	TYR119
A	ASN343
A	ALA344
A	LYS348
A	HOH507

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 406

Chain	Residue
A	LYS303
A	ARG306
A	MG411
A	HOH537

---

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 A 407

Chain	Residue
A	ASN266
A	ALA267
A	MG411
A	HOH511

---

site_id	AC8
Number of Residues	2
Details	binding site for residue NA A 408

Chain	Residue
A	ASP246
A	HOH541

---

site_id	AC9
Number of Residues	2
Details	binding site for residue NA A 409

Chain	Residue
A	ASP19
A	ASN24

---

site_id	AD1
Number of Residues	5
Details	binding site for residue CA A 410

Chain	Residue
A	ASP19
A	TRP20
A	GLU22
A	ASN24
A	GLU33

---

site_id	AD2
Number of Residues	2
Details	binding site for residue MG A 411

Chain	Residue
A	SO4406
A	SO4407

---

site_id	AD3
Number of Residues	4
Details	binding site for residue MG A 412

Chain	Residue
A	GLU60
A	LYS114
A	ASN115
A	SO4402

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	141
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30575723","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"30575723","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	25
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30575723","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30575723","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6G7O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---