6YXF

Cryogenic human adiponectin receptor 2 (ADIPOR2) with Gd-DO3 ligand determined by Serial Crystallography (SSX) using CrystalDirect

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	HIS202
A	HIS348
A	HIS352
A	OLA402

---

site_id	AC2
Number of Residues	12
Details	binding site for residue OLA A 402

Chain	Residue
A	TYR321
A	ALA325
A	TYR328
A	HIS348
A	PHE351
A	PHE354
A	ZN401
A	ASP219
A	TYR220
A	ILE223
A	LEU226
A	PHE282

---

site_id	AC3
Number of Residues	6
Details	binding site for residue OLB A 403

Chain	Residue
A	SER230
A	GLY289
A	LEU314
A	MET315
A	TYR321
A	HIS362

---

site_id	AC4
Number of Residues	11
Details	binding site for residue OLB A 404

Chain	Residue
A	GLY163
A	ILE164
A	MET167
A	PHE168
A	ARG169
A	PRO170
A	ASN171
A	LYS181
A	GLY276
A	ILE322
A	OLB407

---

site_id	AC5
Number of Residues	6
Details	binding site for residue OLB A 405

Chain	Residue
A	VAL157
A	PHE158
A	CYS161
A	ILE164
A	PHE165
A	PHE168

---

site_id	AC6
Number of Residues	4
Details	binding site for residue OLB A 406

Chain	Residue
A	GLN179
A	LEU189
A	VAL232
A	TYR240

---

site_id	AC7
Number of Residues	7
Details	binding site for residue OLB A 407

Chain	Residue
A	ASN171
A	PRO272
A	GLN273
A	GLY276
A	ARG331
A	ARG335
A	OLB404

---

site_id	AC8
Number of Residues	1
Details	binding site for residue GD A 408

Chain	Residue
A	DO3410

---

site_id	AC9
Number of Residues	2
Details	binding site for residue GD A 409

Chain	Residue
A	GLU209
A	DO3411

---

site_id	AD1
Number of Residues	5
Details	binding site for residue DO3 A 410

Chain	Residue
A	VAL105
A	GD408
A	HOH504
H	GD302
H	DO3303

---

site_id	AD2
Number of Residues	3
Details	binding site for residue DO3 A 411

Chain	Residue
A	GLU209
A	ARG213
A	GD409

---

site_id	AD3
Number of Residues	11
Details	binding site for residue OLB H 301

Chain	Residue
A	SER131
A	PHE132
A	ARG133
A	PHE136
A	GLY301
A	PHE302
A	LEU303
H	ASN167
H	HIS169
H	ASN170
H	GLY207

---

site_id	AD4
Number of Residues	2
Details	binding site for residue GD H 302

Chain	Residue
A	DO3410
H	DO3303

---

site_id	AD5
Number of Residues	4
Details	binding site for residue DO3 H 303

Chain	Residue
A	DO3410
H	ASN54
H	SER55
H	GD302

---

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	12
Details	LIPOCALIN Lipocalin signature. GGS..EFEGRWRVI

Chain	Residue	Details
A	GLY-4-ILE106

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25855295

Chain	Residue	Details
A	ASN148-PHE168

---

site_id	SWS_FT_FI2
Number of Residues	52
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:25855295

Chain	Residue	Details
A	ARG169-LYS181
A	LEU235-PRO245
A	HIS295-GLY309
A	GLN370-LEU386

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25855295

Chain	Residue	Details
A	VAL182-HIS202

---

site_id	SWS_FT_FI4
Number of Residues	33
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25855295

Chain	Residue	Details
A	THR203-ARG213
A	ASP267-GLN273
A	ARG331-HIS348

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25855295

Chain	Residue	Details
A	LEU214-TRP234

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25855295

Chain	Residue	Details
A	CYS246-TRP266

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25855295

Chain	Residue	Details
A	TYR274-LEU294

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25855295

Chain	Residue	Details
A	GLN310-ALA330

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:25855295

Chain	Residue	Details
A	GLN349-LEU369

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:25855295

Chain	Residue	Details
A	HIS202
A	HIS348
A	HIS352

---