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6YVM

Human OMPD-domain of UMPS in complex with the substrate OMP at 1.25 Angstroms resolution, 2.13 MGy exposure

Functional Information from GO Data
ChainGOidnamespacecontents
A0004590molecular_functionorotidine-5'-phosphate decarboxylase activity
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0044205biological_process'de novo' UMP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues22
Detailsbinding site for residue OMP A 501
ChainResidue
ASER257
AASN341
AMET371
ASER372
APRO417
AGLN430
ATYR432
AGLY450
AARG451
AU502
AHOH631
AASP259
AHOH634
AHOH676
AHOH759
ALYS281
AHIS283
AASP312
AALY314
AASP317
AILE318
ATHR321

site_idAC2
Number of Residues20
Detailsbinding site for residue U A 502
ChainResidue
ASER257
AASP259
ALYS281
AHIS283
AASP312
AALY314
AASP317
AILE318
ATHR321
AMET371
ASER372
APRO417
AGLN430
ATYR432
AGLY450
AARG451
AOMP501
AHOH631
AHOH634
AHOH676

site_idAC3
Number of Residues5
Detailsbinding site for residue GOL A 503
ChainResidue
AARG235
ALYS468
AHOH611
AHOH912
AHOH921

site_idAC4
Number of Residues5
Detailsbinding site for residue SO4 A 504
ChainResidue
ATHR374
AGLY429
AHOH620
AHOH633
AHOH640

site_idAC5
Number of Residues1
Detailsbinding site for residue SO4 A 505
ChainResidue
AARG235

site_idAC6
Number of Residues3
Detailsbinding site for residue SO4 A 506
ChainResidue
AASN433
AARG442
AHOH604

site_idAC7
Number of Residues2
Detailsbinding site for residue SO4 A 507
ChainResidue
AGLY380
AARG384

site_idAC8
Number of Residues4
Detailsbinding site for residue SO4 A 508
ChainResidue
ASER348
ALYS352
AHIS393
AHOH632

site_idAC9
Number of Residues4
Detailsbinding site for residue SO4 A 509
ChainResidue
AARG388
AHOH644
AHOH665
AHOH735

Functional Information from PROSITE/UniProt
site_idPS00156
Number of Residues14
DetailsOMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFeDrKfaDIGnTV
ChainResidueDetails
AILE309-VAL322

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD
ChainResidueDetails
APRO435

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD, ECO:0007744|PDB:2QCH
ChainResidueDetails
AGLU437

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCL
ChainResidueDetails
AARG459

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
AGLU392

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PDB entries from 2024-11-06

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