Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6YUF

Cohesin complex with loader gripping DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000779	cellular_component	condensed chromosome, centromeric region
A	0003677	molecular_function	DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0007062	biological_process	sister chromatid cohesion
A	0007064	biological_process	mitotic sister chromatid cohesion
A	0008278	cellular_component	cohesin complex
A	0016887	molecular_function	ATP hydrolysis activity
A	0030892	cellular_component	mitotic cohesin complex
A	0030893	cellular_component	meiotic cohesin complex
A	0051276	biological_process	chromosome organization
A	0051301	biological_process	cell division
A	0061776	molecular_function	ATP-dependent topological DNA co-entrapment activity
A	0140588	biological_process	chromatin looping
B	0000070	biological_process	mitotic sister chromatid segregation
B	0000775	cellular_component	chromosome, centromeric region
B	0000779	cellular_component	condensed chromosome, centromeric region
B	0000785	cellular_component	chromatin
B	0003682	molecular_function	chromatin binding
B	0003690	molecular_function	double-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005721	cellular_component	pericentric heterochromatin
B	0005730	cellular_component	nucleolus
B	0006281	biological_process	DNA repair
B	0006302	biological_process	double-strand break repair
B	0006974	biological_process	DNA damage response
B	0007059	biological_process	chromosome segregation
B	0007062	biological_process	sister chromatid cohesion
B	0007064	biological_process	mitotic sister chromatid cohesion
B	0008278	cellular_component	cohesin complex
B	0030892	cellular_component	mitotic cohesin complex
B	0033553	cellular_component	rDNA heterochromatin
B	0044820	biological_process	mitotic telomere tethering at nuclear periphery
B	0045143	biological_process	homologous chromosome segregation
B	0051301	biological_process	cell division
B	0061776	molecular_function	ATP-dependent topological DNA co-entrapment activity
B	0099115	cellular_component	chromosome, subtelomeric region
B	0140588	biological_process	chromatin looping
B	1990342	cellular_component	heterochromatin island
B	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange
C	0000166	molecular_function	nucleotide binding
C	0000779	cellular_component	condensed chromosome, centromeric region
C	0003677	molecular_function	DNA binding
C	0003690	molecular_function	double-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005829	cellular_component	cytosol
C	0007059	biological_process	chromosome segregation
C	0007064	biological_process	mitotic sister chromatid cohesion
C	0008278	cellular_component	cohesin complex
C	0016887	molecular_function	ATP hydrolysis activity
C	0030892	cellular_component	mitotic cohesin complex
C	0030893	cellular_component	meiotic cohesin complex
C	0031619	biological_process	homologous chromosome orientation in meiotic metaphase I
C	0051276	biological_process	chromosome organization
C	0051301	biological_process	cell division
C	0061776	molecular_function	ATP-dependent topological DNA co-entrapment activity
C	0140588	biological_process	chromatin looping
D	0000070	biological_process	mitotic sister chromatid segregation
D	0000228	cellular_component	nuclear chromosome
D	0001671	molecular_function	ATPase activator activity
D	0003682	molecular_function	chromatin binding
D	0003690	molecular_function	double-stranded DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005829	cellular_component	cytosol
D	0007064	biological_process	mitotic sister chromatid cohesion
D	0010468	biological_process	regulation of gene expression
D	0032116	cellular_component	SMC loading complex
D	0034087	biological_process	establishment of mitotic sister chromatid cohesion
D	0061775	molecular_function	cohesin loader activity
D	0071169	biological_process	establishment of protein localization to chromatin
D	0090694	cellular_component	Scc2-Scc4 cohesin loading complex
D	0140588	biological_process	chromatin looping
D	1990342	cellular_component	heterochromatin island
D	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue BEF A 1301

Chain	Residue
A	LYS38
A	SER39
A	ARG57
A	GLN147
A	ASP1160
A	ADP1302

site_id	AC2
Number of Residues	18
Details	binding site for residue ADP A 1302

Chain	Residue
A	GLY37
A	LYS38
A	SER39
A	ASN40
A	ARG57
A	GLU63
A	LEU64
A	ILE65
A	ARG1209
A	BEF1301
C	LEU1092
C	GLN1096
C	LEU1097
C	SER1098
C	GLY1099
A	LYS13
A	SER14
A	GLY35

site_id	AC3
Number of Residues	6
Details	binding site for residue BEF C 1201

Chain	Residue
C	ASN34
C	SER39
C	GLN141
C	ASP1125
C	GLU1126
C	ADP1202

site_id	AC4
Number of Residues	15
Details	binding site for residue ADP C 1202

Chain	Residue
A	LYS1124
A	ARG1127
A	GLN1131
A	SER1133
C	SER13
C	ASN34
C	GLY35
C	SER36
C	GLY37
C	LYS38
C	SER39
C	ASN40
C	ALA63
C	LEU65
C	BEF1201

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGEKTMAALALLF

Chain	Residue	Details
A	LEU1132-PHE1146

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18257517","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	37
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	37
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	35
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	37
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	39
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	37
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	36
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)