6YSY

Skeletal Myosin bound to MPH-220, MgADP-VO4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000146	molecular_function	microfilament motor activity
A	0000166	molecular_function	nucleotide binding
A	0003774	molecular_function	cytoskeletal motor activity
A	0003779	molecular_function	actin binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005859	cellular_component	muscle myosin complex
A	0006936	biological_process	muscle contraction
A	0007605	biological_process	sensory perception of sound
A	0014704	cellular_component	intercalated disc
A	0016459	cellular_component	myosin complex
A	0016460	cellular_component	myosin II complex
A	0030016	cellular_component	myofibril
A	0031672	cellular_component	A band
A	0032982	cellular_component	myosin filament
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0051015	molecular_function	actin filament binding
B	0005509	molecular_function	calcium ion binding
B	0006936	biological_process	muscle contraction
B	0008307	molecular_function	structural constituent of muscle
B	0016459	cellular_component	myosin complex
B	0016460	cellular_component	myosin II complex
B	0043292	cellular_component	contractile muscle fiber

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue ADP A 2001

Chain	Residue
A	ASN127
A	ASN241
A	VO42002
A	MG2003
A	HOH2102
A	PRO128
A	M3L130
A	TYR135
A	GLY182
A	GLY184
A	LYS185
A	THR186
A	VAL187

---

site_id	AC2
Number of Residues	12
Details	binding site for residue VO4 A 2002

Chain	Residue
A	GLU180
A	SER181
A	GLY182
A	LYS185
A	ASN241
A	SER244
A	SER245
A	ALA466
A	GLY467
A	ADP2001
A	MG2003
A	HOH2101

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 2003

Chain	Residue
A	THR186
A	SER245
A	ADP2001
A	VO42002
A	HOH2101
A	HOH2102

---

site_id	AC4
Number of Residues	13
Details	binding site for residue PJT A 2004

Chain	Residue
A	ARG246
A	PHE247
A	GLY248
A	TYR269
A	LEU270
A	ILE465
A	ALA466
A	LEU476
A	CYS480
A	LYS599
A	VAL650
A	PHE654
A	LEU661

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	49
Details	Domain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Region: {"description":"Actin-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00782","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Region: {"description":"Actin-binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00782","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q29RW1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q29RW1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q29RW1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Pros-methylhistidine","evidences":[{"source":"PubMed","id":"5539225","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	35
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	35
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02600","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02600","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---